TANGO2

This gene belongs to the transport and Golgi organization family, whose members are predicted to play roles in secretory protein loading in the endoplasmic reticulum. Depletion of this gene in Drosophila S2 cells causes fusion of the Golgi with the ER. In mouse tissue culture cells, this protein co-localizes with a mitochondrially targeted mCherry protein and displays very low levels of co-localization with Golgi and peroxisomes. Allelic variants of this gene are associated with rhabdomyolysis, metabolic crises with encephalopathy, and cardiac arrhythmia. [provided by RefSeq, Apr 2016]

Description

Transport and golgi organization 2 homolog

Tissue specificity

Tissue enhanced (heart muscle)

Predicted location

Intracellular

Protein family

Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (20017014 - 20067164)

Ensembl ID

ENSG00000183597  (ver. 103.38)

Orthologs

Mouse Tango2: ENSMUSG00000013539

UniProt

Q6ICL3

neXtProt

NX_Q6ICL3

Human splice variants
Mouse splice variants

Protein structure