Tissue expression
Cell line expression
Protein structure
FBXW8
F-box and WD repeat domain containing 8FBW6, FBW8, FBX29, FBXO29
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains a WD-40 domain, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Top validated antibodies |
|||||
antibodies-online | ![]() |
4 references | Polyclonal |
|
|
Novus Biologicals | ![]() |
2 references | Polyclonal |
|
|
Acris Antibodies GmbH | ![]() |
Polyclonal |
|
||
OriGene | ![]() |
Polyclonal |
|
||
NSJ Bioreagents | ![]() |
Polyclonal |
|