MTO1

This gene encodes a mitochondrial protein thought to be involved in mitochondrial tRNA modification. The encoded protein may also play a role in the expression of the non-syndromic and aminoglycoside-induced deafness phenotypes associated with a specific mutation in the mitochondrial 12S rRNA gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Mitochondrial tRNA translation optimization 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (73461578 - 73509236)

Ensembl ID

ENSG00000135297  (ver. 103.38)

Orthologs

Mouse Mto1: ENSMUSG00000032342

UniProt

Q9Y2Z2

neXtProt

NX_Q9Y2Z2

Human splice variants
Mouse splice variants

Protein structure