EHD2

This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway. [provided by RefSeq, Jul 2008]

Description

EH domain containing 2

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

19 (47713422 - 47743134)

Ensembl ID

ENSG00000024422  (ver. 103.38)

Orthologs

Mouse Ehd2: ENSMUSG00000074364

UniProt

Q9NZN4

neXtProt

NX_Q9NZN4

Human splice variants
Mouse splice variants

Protein structure