Antibody data
- Antibody Data
- Antigen structure
- References [42]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 20540-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20540-1-AP, RRID:AB_10694569
- Product name
- AXIN2 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated AXIN2 antibody (Cat. #20540-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.
Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform.
Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.
Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway.
Pancreatic stellate cell-derived exosomal tRF-19-PNR8YPJZ promotes proliferation and mobility of pancreatic cancer through AXIN2.
Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.
Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment.
Frequent PIK3CA mutation in normal endometrial gland drives spheroid formation and may be involved in stem cell propagation.
Fucose promotes intestinal stem cell-mediated intestinal epithelial development through promoting Akkermansia-related propanoate metabolism.
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.
B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin.
TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting the Wnt/β-Catenin Signaling Pathway.
Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity.
Human Neuralized is a novel tumour suppressor targeting Wnt/β-catenin signalling in colon cancer.
Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis.
Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model.
PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells.
Huoxin pill prevents excessive inflammation and cardiac dysfunction following myocardial infarction by inhibiting adverse Wnt/β‑catenin signaling activation.
Strains producing different short-chain fatty acids alleviate DSS-induced ulcerative colitis by regulating intestinal microecology.
Identification of a novel Calpain-2-SRC feed-back loop as necessity for β-Catenin accumulation and signaling activation in hepatocellular carcinoma.
Efficacy of auranofin as an inhibitor of desmoid progression.
Kangxianruangan granule‑containing serum mediated inhibition of hepatic oval cell differentiation into hepatocellular carcinoma cells via the Wnt‑1/β‑catenin signaling pathway.
Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer.
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC development.
Ultrathin 2D Titanium Carbide MXene (Ti(3) C(2) T(x) ) Nanoflakes Activate WNT/HIF-1α-Mediated Metabolism Reprogramming for Periodontal Regeneration.
AXIN2 Reduces the Survival of Porcine Induced Pluripotent Stem Cells (piPSCs).
Babao Dan is a robust anti-tumor agent via inhibiting wnt/β-catenin activation and cancer cell stemness.
TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling.
Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer.
circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.
[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].
TRIB3 confers glioma cell stemness via interacting with β-catenin.
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Long Non-Coding RNA THOR Enhances the Stem Cell-Like Traits of Triple-Negative Breast Cancer Cells Through Activating β-Catenin Signaling.
Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR.
LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.
Secreted AGR2 promotes invasion of colorectal cancer cells via Wnt11-mediated non-canonical Wnt signaling.
Jin H, Huang X, Pan Q, Ma N, Xie X, Wei Y, Yu F, Wen W, Zhang B, Zhang P, Chen X, Wang J, Liu RY, Lin J, Meng X, Lee MH
Nature communications 2024 Mar 21;15(1):2551
Nature communications 2024 Mar 21;15(1):2551
Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform.
Zhou H, Li Z, Jing S, Wang B, Ye Z, Xiong W, Liu Y, Liu Y, Xu C, Kumeria T, He Y, Ye Q
Journal of nanobiotechnology 2024 Jun 20;22(1):351
Journal of nanobiotechnology 2024 Jun 20;22(1):351
Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.
Jin H, Liu C, Liu X, Wang H, Zhang Y, Liu Y, Li J, Yu Z, Liu HX
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117270
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117270
Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway.
Zhao J, Shi Y, Ma Y, Pan L, Wang Y, Yuan L, Dong J, Ying J
Frontiers in pharmacology 2023;14:1143427
Frontiers in pharmacology 2023;14:1143427
Pancreatic stellate cell-derived exosomal tRF-19-PNR8YPJZ promotes proliferation and mobility of pancreatic cancer through AXIN2.
Cao W, Dai S, Ruan W, Long T, Zeng Z, Lei S
Journal of cellular and molecular medicine 2023 Sep;27(17):2533-2546
Journal of cellular and molecular medicine 2023 Sep;27(17):2533-2546
Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.
Liu T, Fan MQ, Xie XX, Shu QP, Du XH, Qi LZ, Zhang XD, Zhang MH, Shan G, Du RL, Li SZ
Journal of translational medicine 2023 Sep 22;21(1):656
Journal of translational medicine 2023 Sep 22;21(1):656
USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.
Liu Y, Ma J, Lu S, He P, Dong W
Chinese medical journal 2023 Sep 20;136(18):2229-2242
Chinese medical journal 2023 Sep 20;136(18):2229-2242
Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment.
Wang Z, Li XN, Yang SN, Wang Y, Gao KJ, Han B, Ma AJ
World journal of psychiatry 2023 Sep 19;13(9):630-644
World journal of psychiatry 2023 Sep 19;13(9):630-644
Frequent PIK3CA mutation in normal endometrial gland drives spheroid formation and may be involved in stem cell propagation.
Sato S, Nakayama K, Kanno K, Sultana R, Ishikawa M, Ishibashi T, Yamashita H, Kyo S
Cancer science 2023 Jun;114(6):2335-2344
Cancer science 2023 Jun;114(6):2335-2344
Fucose promotes intestinal stem cell-mediated intestinal epithelial development through promoting Akkermansia-related propanoate metabolism.
Duan C, Wu J, Wang Z, Tan C, Hou L, Qian W, Han C, Hou X
Gut microbes 2023 Jan-Dec;15(1):2233149
Gut microbes 2023 Jan-Dec;15(1):2233149
mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.
Chen Z, He Q, Lu T, Wu J, Shi G, He L, Zong H, Liu B, Zhu P
Nature communications 2023 Feb 27;14(1):1121
Nature communications 2023 Feb 27;14(1):1121
B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin.
Zhou C, Zhu X, Liu N, Dong X, Zhang X, Huang H, Tang Y, Liu S, Hu M, Wang M, Deng X, Li S, Zhang R, Huang Y, Lyu H, Xiao S, Luo S, Ali DW, Michalak M, Chen XZ, Wang Z, Tang J
Signal transduction and targeted therapy 2023 Feb 17;8(1):66
Signal transduction and targeted therapy 2023 Feb 17;8(1):66
TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting the Wnt/β-Catenin Signaling Pathway.
Lou YX, Gu J, Zhu L, Sun SQ, Hao XL, Chen JP, Han F, Wang DD, Jiang X, Liu JY
Laboratory investigation; a journal of technical methods and pathology 2023 Dec;103(12):100260
Laboratory investigation; a journal of technical methods and pathology 2023 Dec;103(12):100260
Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity.
Zhang X, Wu N, Huang H, Li S, Liu S, Zhang R, Huang Y, Lyu H, Xiao S, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J
Oncogene 2023 Aug;42(32):2439-2455
Oncogene 2023 Aug;42(32):2439-2455
Human Neuralized is a novel tumour suppressor targeting Wnt/β-catenin signalling in colon cancer.
Yi JM, Kang TH, Han YK, Park HY, Yang JH, Bae JH, Suh JS, Kim TJ, Kim JG, Cui YH, Suzuki H, Kumegawa K, Kim SJ, Zhao Y, Park IJ, Hong SM, Chung JY, Lee SJ
EMBO reports 2023 Aug 3;24(8):e56335
EMBO reports 2023 Aug 3;24(8):e56335
Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis.
Kim H, Villareal LB, Liu Z, Haneef M, Falcon DM, Martin DR, Lee HJ, Dame MK, Attili D, Chen Y, Varani J, Spence JR, Kovbasnjuk O, Colacino JA, Lyssiotis CA, Lin HC, Shah YM, Xue X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(10):e2207693
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(10):e2207693
Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model.
Yang X, Luo G, Fu L, Huang H, Wang L, Yin L, Zhang X, Wang T, Ma X, Feng T, Ye J
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3193572
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3193572
PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells.
Liao S, Wang K, Zhang L, Shi G, Wang Z, Chen Z, Zhu P, He Q
Frontiers in cell and developmental biology 2022;10:864051
Frontiers in cell and developmental biology 2022;10:864051
Huoxin pill prevents excessive inflammation and cardiac dysfunction following myocardial infarction by inhibiting adverse Wnt/β‑catenin signaling activation.
He J, Wo D, Ma E, Wang Q, Chen J, Gao Q, Zhao Q, Shen F, Peng J, Zhu W, Ren DN
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154293
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154293
Strains producing different short-chain fatty acids alleviate DSS-induced ulcerative colitis by regulating intestinal microecology.
Yang S, Shang J, Liu L, Tang Z, Meng X
Food & function 2022 Nov 28;13(23):12156-12169
Food & function 2022 Nov 28;13(23):12156-12169
Identification of a novel Calpain-2-SRC feed-back loop as necessity for β-Catenin accumulation and signaling activation in hepatocellular carcinoma.
Ma XL, Zhu KY, Chen YD, Tang WG, Xie SH, Zheng H, Tong Y, Wang YC, Ren N, Guo L, Lu RQ
Oncogene 2022 Jul;41(27):3554-3569
Oncogene 2022 Jul;41(27):3554-3569
Efficacy of auranofin as an inhibitor of desmoid progression.
Ito K, Nishida Y, Hamada S, Shimizu K, Sakai T, Ohkawara B, Alman BA, Enomoto A, Ikuta K, Koike H, Zhang J, Ohno K, Imagama S
Scientific reports 2022 Jul 13;12(1):11918
Scientific reports 2022 Jul 13;12(1):11918
Kangxianruangan granule‑containing serum mediated inhibition of hepatic oval cell differentiation into hepatocellular carcinoma cells via the Wnt‑1/β‑catenin signaling pathway.
Tang W, Xue J, Luo L, Wang Y, Cai X, Liu Y, Huang D, Wang X, He T, Lu D, Yang F
Molecular medicine reports 2022 Feb;25(2)
Molecular medicine reports 2022 Feb;25(2)
Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer.
Ma Y, Zhang P, Zhang Q, Wang X, Miao Q, Lyu X, Cui B, Ma H
Oncology letters 2021 Oct;22(4):688
Oncology letters 2021 Oct;22(4):688
TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.
Zhou C, Liang Y, Zhou L, Yan Y, Liu N, Zhang R, Huang Y, Wang M, Tang Y, Ali DW, Wang Y, Michalak M, Chen XZ, Tang J
Autophagy 2021 Oct;17(10):3175-3195
Autophagy 2021 Oct;17(10):3175-3195
An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC development.
Wang R, Liu J, Li K, Yang G, Chen S, Wu J, Xie X, Ren H, Pang Y
Journal of experimental & clinical cancer research : CR 2021 Oct 13;40(1):318
Journal of experimental & clinical cancer research : CR 2021 Oct 13;40(1):318
Ultrathin 2D Titanium Carbide MXene (Ti(3) C(2) T(x) ) Nanoflakes Activate WNT/HIF-1α-Mediated Metabolism Reprogramming for Periodontal Regeneration.
Cui D, Kong N, Ding L, Guo Y, Yang W, Yan F
Advanced healthcare materials 2021 Nov;10(22):e2101215
Advanced healthcare materials 2021 Nov;10(22):e2101215
AXIN2 Reduces the Survival of Porcine Induced Pluripotent Stem Cells (piPSCs).
Zhang R, Yu S, Shen Q, Zhao W, Zhang J, Wu X, Zhu Z, Wu X, Li N, Peng S, Hua J
International journal of molecular sciences 2021 Nov 30;22(23)
International journal of molecular sciences 2021 Nov 30;22(23)
Babao Dan is a robust anti-tumor agent via inhibiting wnt/β-catenin activation and cancer cell stemness.
Xie X, Chen J, Wo D, Ma E, Ning Y, Peng J, Zhu W, Ren DN
Journal of ethnopharmacology 2021 Nov 15;280:114449
Journal of ethnopharmacology 2021 Nov 15;280:114449
TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling.
Zhang X, Luo Y, Li Q
OncoTargets and therapy 2020;13:5819-5830
OncoTargets and therapy 2020;13:5819-5830
Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer.
Zhang J, Ying Y, Li M, Wang M, Huang X, Jia M, Zeng J, Ma C, Zhang Y, Li C, Wang X, Shu XS
Theranostics 2020;10(22):10016-10030
Theranostics 2020;10(22):10016-10030
circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.
Ma Z, Han C, Xia W, Wang S, Li X, Fang P, Yin R, Xu L, Yang L
Cell death & disease 2020 May 11;11(5):356
Cell death & disease 2020 May 11;11(5):356
[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].
Wu CF, Xiao M, Wang YL, Threadgill MD, Li M, Tang Y, Lin X, Yang L, Li QS, Li X
Molekuliarnaia biologiia 2020 Mar-Apr;54(2):252-261
Molekuliarnaia biologiia 2020 Mar-Apr;54(2):252-261
TRIB3 confers glioma cell stemness via interacting with β-catenin.
Lu Y, Li L, Chen L, Gao Y, Chen X, Cao Y
Environmental toxicology 2020 Jun;35(6):697-706
Environmental toxicology 2020 Jun;35(6):697-706
LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.
Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J
Molecular cancer 2020 Jul 29;19(1):118
Molecular cancer 2020 Jul 29;19(1):118
Long Non-Coding RNA THOR Enhances the Stem Cell-Like Traits of Triple-Negative Breast Cancer Cells Through Activating β-Catenin Signaling.
Wang B, Ye Q, Zou C
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 14;26:e923507
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 14;26:e923507
Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.
Liao X, Song G, Xu Z, Bu Y, Chang F, Jia F, Xiao X, Ren X, Zhang M, Jia Q
BMC cancer 2020 Jan 13;20(1):31
BMC cancer 2020 Jan 13;20(1):31
Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.
Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC
Cell research 2019 Jun;29(6):460-473
Cell research 2019 Jun;29(6):460-473
MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.
Yuan J, Tan L, Yin Z, Zhu W, Tao K, Wang G, Shi W, Gao J
Cell death & disease 2019 Jun 11;10(6):454
Cell death & disease 2019 Jun 11;10(6):454
Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR.
Sun WX, Han HW, Yang MK, Wen ZL, Wang YS, Fu JY, Lu YT, Wang MY, Bao JX, Lu GH, Qi JL, Wang XM, Lin HY, Yang YH
Bioorganic & medicinal chemistry 2019 Dec 1;27(23):115153
Bioorganic & medicinal chemistry 2019 Dec 1;27(23):115153
LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.
Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z
Nature cell biology 2018 Oct;20(10):1134-1144
Nature cell biology 2018 Oct;20(10):1134-1144
Secreted AGR2 promotes invasion of colorectal cancer cells via Wnt11-mediated non-canonical Wnt signaling.
Tian S, Hu J, Tao K, Wang J, Chu Y, Li J, Liu Z, Ding X, Xu L, Li Q, Cai M, Gao J, Shuai X, Wang G, Wang L, Wang Z
Experimental cell research 2018 Mar 15;364(2):198-207
Experimental cell research 2018 Mar 15;364(2):198-207
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AXIN2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human AXIN2. This antibody recognizes human, mouse, rat antigen. The AXIN2 antibody has been validated for the following applications: ELISA, WB analysis.