20540-1-AP

antibody from Proteintech Group

Targeting: AXIN2 DKFZp781B0869, MGC126582

Provider product page for 20540-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [69]
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Validations
Western blot [1]

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Product number: 20540-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#20540-1-AP, RRID:AB_10694569
Product name: AXIN2 antibody
Antibody type: Polyclonal
Description: KD/KO validated AXIN2 antibody (Cat. #20540-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AXIN2 protein structure - 20540-1-AP shown in red.

Submitted references Discovery of potent TNIK inhibitors containing a 1H-pyrrolo[2,3-b]pyridine scaffold as promising therapeutics for colorectal cancer.

Niu X, Zhang S, Xu B, Deng W, Zhang X, He H, Shi X, Tong M, Chen J, Qin M
European journal of medicinal chemistry 2026 May 5;309:118717

Biomimetic Multilayered Gas-Foaming Scaffold with Sustained bFGF Delivery for Annulus Fibrosus Regeneration.

Chen Y, Li Y, Wei Z, Du L, Qian M, Wang J, Mo X, Deng Z, Ye X, Yu J
Advanced healthcare materials 2026 Feb;15(7):e02833

LncRNA miR17HG promotes tumor progression through AXIN2 by sponging miR-144-3p in bladder cancer.

Chen Q, Wu K, Cai B, Yu X, Zhang X, Yang Y
World journal of surgical oncology 2026 Feb 21;24(1)

A study on the mechanism of IGFBP-3 affecting autophagy to partially protect against inflammatory damage in inflammatory bowel disease.

Liu J, Ye J, Ye S, Chen L, Zhu Y, Wang L, Yu K, Ma X
Journal of bioenergetics and biomembranes 2026 Apr 22;

CYMP-AS1 Promotes Ovarian Cancer Progression by Enhancing the Intracellular Translocation of hnRNPM and Reducing the Stability of AXIN2 mRNA.

Wang Y, Meng Y, Xia W, Liang Y, Wang Y, Li P, Fang L
Oncology research 2025;33(8):2141-2159

Over-expressed Phospholamban in Cancer-associated Fibroblasts Is a Driver for CMS4 Subtype Colorectal Cancer Formation.

Li T, Fei Y, Sun X, Zhu J, Fang X, Meng F, Wang D, Zhang X, Liu C, Du Q
Cellular and molecular gastroenterology and hepatology 2025;19(9):101524

Dual-edged mechanisms of α-tomatine in hepatocellular carcinoma by suppression of Wnt/β-catenin signaling versus RelB-Driven resistance in tumor therapy.

Wang T, Xu C, Yuan Y, Zhang B
Frontiers in pharmacology 2025;16:1616975

Inhibition of ICAM1 diminishes stemness and enhances antitumor immunity in glioblastoma via β-catenin/PD-L1 signaling.

Guo M, Yuan Z, Jin X, Li X, Deng Y, Zhou S, Niu R, Bae J, Park JB, Shi B, Yin J
Nature communications 2025 Sep 30;16(1):8642

TET2 repression contributes to EGFR TKI resistance in EGFR-mutant non-small cell lung cancer through regulating AXIN2 methylation.

Ying H, Chen Y, Lin W, Fan Y, Chen M, Jin Y
Scientific reports 2025 Oct 17;15(1):36324

USP30-AS1 Dictates Breast Cancer Cell Fate and Chemoresistance via a miR-3646/FZD7/Wnt/β-Catenin Circuit.

He Q, Yang S, Xin Q, Jiang Y, Jiang L, Xu N
Current issues in molecular biology 2025 Nov 24;47(12)

Up-regulation of Ifi27l2a expression in bone marrow monocytes contributes to glucocorticoid-induced bone loss.

Wang Z, Huang C, Liu S, Xiao P, Lu Z, Xu Y, Tian Y
Communications biology 2025 Nov 17;8(1):1590

SMOC2 promotes peritoneal metastasis of gastric cancer involving Wnt/β-catenin pathway modulation and inducing angiogenesis.

Li C, Yin L, Zhao D, Jiang Y, Li X, Yin Q, Xu J, Huang Y, Ni J, Ying J
Clinical and experimental medicine 2025 Nov 11;25(1):372

GIV/Girdin Modulation of Microglial Activation in Ischemic Stroke: Impact of FTO-Mediated m6A Modification.

Xie P, Xia M, Long T, Guo D, Cao W, Sun P, Yu W
Molecular neurobiology 2025 May;62(5):5501-5517

Dendritic Poly(l-lysine)-Based Nanoparticle Loading with siDNMT1 to Alleviate Basal Cell Carcinoma Progression by Inhibiting Methylation of AXIN2.

Xiong S, Wang X, Yang Y, Gan Y, Gao A
ACS applied materials & interfaces 2025 May 21;17(20):29119-29131

Therapeutic targeting de novo purine biosynthesis driven by β-catenin-dependent PPAT upregulation in hepatoblastoma.

Ding M, Ma C, Lin Y, Fang H, Xu Y, Wang S, Chen Y, Zhou J, Gao H, Shan Y, Yang L, Sun H, Tang Y, Wu X, Zhu L, Zheng L, Assaraf YG, Zhou BS, Gu S, Li H
Cell death & disease 2025 Mar 17;16(1):179

Vdr mediates Wnt signaling pathway to regulate odontoblasts differentiation during dentin apposition.

Wu Y, Zhu W, Wang L, Zhang W, Zhang K, Sun M, Guan J, Liu S, Liu Y
European journal of pharmacology 2025 Mar 15;991:177333

Calcaratarin D, a labdane diterpenoid, attenuates bleomycin-induced pulmonary fibrosis by blocking Wnt/β-catenin signaling pathway.

Liao W, Ang Y, Kee ACL, Lim V, Lim AYH, Chai CLL, Wong WSF
Pharmacological research 2025 Jun;216:107756

Serine/threonine/tyrosine kinase 1 drives pancreatic carcinogenesis via GSK3β sequestration-mediated Wnt/β-catenin pathway hyperactivation.

Zhou C, Dong X, Li S, Xi Y, Liu Y, Qian X, Song Z, Zhou L, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Liu W, Xiong Y, Wang Z, Yan C, Zhang Z, Zhu H, Chen XZ, Song Z, Tang J
Signal transduction and targeted therapy 2025 Jun 30;10(1):205

Two novel AXIN2 variants in isolated tooth agenesis and the AXIN2-associated tooth agenesis pattern.

Geng C, Lin B, Liu Y, Sun K, Yu M, Liu H, Feng H, Han D
BMC oral health 2025 Dec 8;25(1):1883

Colonic epithelial-derived FGF1 drives intestinal stem cell commitment toward goblet cells to suppress inflammatory bowel disease.

Lin Q, Zhang S, Zhang J, Jin Y, Chen T, Lin R, Lv J, Xu W, Wu T, Tian S, Ying L, Li X, Huang Z, Niu J
Nature communications 2025 Apr 5;16(1):3264

Restraint Stress Disrupted Intestinal Homeostasis via 5-HT/HTR7/Wnt/β-Catenin/NF-kB Signaling.

Yu J, Wang Z, Chen Y, Dong Y
International journal of molecular sciences 2025 Apr 24;26(9)

Anti-inflammatory role of low-intensity pulsed ultrasound in inhibiting lipopolysaccharide-induced M1 polarization of RAW264.7 cells via Wnt2b/AXIN/β-catenin.

Yin J, Bao Y, Xu M, Li P, Zhang Z, Xue H, Yang X
PeerJ 2024;12:e18448

Arginine methylation-dependent TRIM47 stability mediated by CARM1 promotes the metastasis of hepatocellular carcinoma.

Tang Y, Meng X, Luo X, Yao W, Tian L, Zhang Z, Zhao Y, Xiao J, Zhu H, Hu J
Cell death discovery 2024 Nov 20;10(1):477

Axin1 regulates tooth root development by inhibiting AKT1-mTORC1 activation and Shh translation in Hertwig's epithelial root sheath.

Zheng X, Huang H, Zhou Z, Guo W, Yang G, Chen Z, Chen D, Chen Y, Yuan G
Development (Cambridge, England) 2024 Nov 1;151(21)

The EIF3H-HAX1 axis increases RAF-MEK-ERK signaling activity to promote colorectal cancer progression.

Jin H, Huang X, Pan Q, Ma N, Xie X, Wei Y, Yu F, Wen W, Zhang B, Zhang P, Chen X, Wang J, Liu RY, Lin J, Meng X, Lee MH
Nature communications 2024 Mar 21;15(1):2551

Repair spinal cord injury with a versatile anti-oxidant and neural regenerative nanoplatform.

Zhou H, Li Z, Jing S, Wang B, Ye Z, Xiong W, Liu Y, Liu Y, Xu C, Kumeria T, He Y, Ye Q
Journal of nanobiotechnology 2024 Jun 20;22(1):351

Screening and identification of miRNAs negatively regulating FAM83A/Wnt/β-catenin signaling pathway in non-small cell lung cancer.

Yuan W, Liu W, Huang H, Chen X, Zhang R, Lyu H, Xiao S, Guo D, Zhang Q, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J
Scientific reports 2024 Jul 29;14(1):17394

Huaier suppresses cisplatin resistance in non-small cell lung cancer by inhibiting the JNK/JUN/IL-8 signaling pathway.

Jin H, Liu C, Liu X, Wang H, Zhang Y, Liu Y, Li J, Yu Z, Liu HX
Journal of ethnopharmacology 2024 Jan 30;319(Pt 2):117270

Calculus bovis inhibits M2 tumor-associated macrophage polarization via Wnt/β-catenin pathway modulation to suppress liver cancer.

Huang Z, Meng FY, Lu LZ, Guo QQ, Lv CJ, Tan NH, Deng Z, Chen JY, Zhang ZS, Zou B, Long HP, Zhou Q, Tian S, Mei S, Tian XF
World journal of gastroenterology 2024 Aug 7;30(29):3511-3533

Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway.

Zhao J, Shi Y, Ma Y, Pan L, Wang Y, Yuan L, Dong J, Ying J
Frontiers in pharmacology 2023;14:1143427

Pancreatic stellate cell-derived exosomal tRF-19-PNR8YPJZ promotes proliferation and mobility of pancreatic cancer through AXIN2.

Cao W, Dai S, Ruan W, Long T, Zeng Z, Lei S
Journal of cellular and molecular medicine 2023 Sep;27(17):2533-2546

Activation of CTNNB1 by deubiquitinase UCHL3-mediated stabilization facilitates bladder cancer progression.

Liu T, Fan MQ, Xie XX, Shu QP, Du XH, Qi LZ, Zhang XD, Zhang MH, Shan G, Du RL, Li SZ
Journal of translational medicine 2023 Sep 22;21(1):656

USP25 promotes hepatocellular carcinoma progression by interacting with TRIM21 via the Wnt/β-catenin signaling pathway.

Liu Y, Ma J, Lu S, He P, Dong W
Chinese medical journal 2023 Sep 20;136(18):2229-2242

Exosomal miR-320e through wnt2targeted inhibition of the Wnt/β-catenin pathway allevisate cerebral small vessel disease and cognitive impairment.

Wang Z, Li XN, Yang SN, Wang Y, Gao KJ, Han B, Ma AJ
World journal of psychiatry 2023 Sep 19;13(9):630-644

Frequent PIK3CA mutation in normal endometrial gland drives spheroid formation and may be involved in stem cell propagation.

Sato S, Nakayama K, Kanno K, Sultana R, Ishikawa M, Ishibashi T, Yamashita H, Kyo S
Cancer science 2023 Jun;114(6):2335-2344

Fucose promotes intestinal stem cell-mediated intestinal epithelial development through promoting Akkermansia-related propanoate metabolism.

Duan C, Wu J, Wang Z, Tan C, Hou L, Qian W, Han C, Hou X
Gut microbes 2023 Jan-Dec;15(1):2233149

mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.

Chen Z, He Q, Lu T, Wu J, Shi G, He L, Zong H, Liu B, Zhu P
Nature communications 2023 Feb 27;14(1):1121

B-lymphoid tyrosine kinase-mediated FAM83A phosphorylation elevates pancreatic tumorigenesis through interacting with β-catenin.

Zhou C, Zhu X, Liu N, Dong X, Zhang X, Huang H, Tang Y, Liu S, Hu M, Wang M, Deng X, Li S, Zhang R, Huang Y, Lyu H, Xiao S, Luo S, Ali DW, Michalak M, Chen XZ, Wang Z, Tang J
Signal transduction and targeted therapy 2023 Feb 17;8(1):66

TC2N Promotes Cell Proliferation and Metastasis in Hepatocellular Carcinoma by Targeting the Wnt/β-Catenin Signaling Pathway.

Lou YX, Gu J, Zhu L, Sun SQ, Hao XL, Chen JP, Han F, Wang DD, Jiang X, Liu JY
Laboratory investigation; a journal of technical methods and pathology 2023 Dec;103(12):100260

Phosphorylated PTTG1 switches its subcellular distribution and promotes β-catenin stabilization and subsequent transcription activity.

Zhang X, Wu N, Huang H, Li S, Liu S, Zhang R, Huang Y, Lyu H, Xiao S, Ali DW, Michalak M, Chen XZ, Zhou C, Tang J
Oncogene 2023 Aug;42(32):2439-2455

Human Neuralized is a novel tumour suppressor targeting Wnt/β-catenin signalling in colon cancer.

Yi JM, Kang TH, Han YK, Park HY, Yang JH, Bae JH, Suh JS, Kim TJ, Kim JG, Cui YH, Suzuki H, Kumegawa K, Kim SJ, Zhao Y, Park IJ, Hong SM, Chung JY, Lee SJ
EMBO reports 2023 Aug 3;24(8):e56335

Transferrin Receptor-Mediated Iron Uptake Promotes Colon Tumorigenesis.

Kim H, Villareal LB, Liu Z, Haneef M, Falcon DM, Martin DR, Lee HJ, Dame MK, Attili D, Chen Y, Varani J, Spence JR, Kovbasnjuk O, Colacino JA, Lyssiotis CA, Lin HC, Shah YM, Xue X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(10):e2207693

Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt/β-Catenin Signaling Pathway in Psoriasis Mouse Model.

Yang X, Luo G, Fu L, Huang H, Wang L, Yin L, Zhang X, Wang T, Ma X, Feng T, Ye J
Evidence-based complementary and alternative medicine : eCAM 2022;2022:3193572

PRC1 and RACGAP1 are Diagnostic Biomarkers of Early HCC and PRC1 Drives Self-Renewal of Liver Cancer Stem Cells.

Liao S, Wang K, Zhang L, Shi G, Wang Z, Chen Z, Zhu P, He Q
Frontiers in cell and developmental biology 2022;10:864051

Huoxin pill prevents excessive inflammation and cardiac dysfunction following myocardial infarction by inhibiting adverse Wnt/β‑catenin signaling activation.

He J, Wo D, Ma E, Wang Q, Chen J, Gao Q, Zhao Q, Shen F, Peng J, Zhu W, Ren DN
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154293

Strains producing different short-chain fatty acids alleviate DSS-induced ulcerative colitis by regulating intestinal microecology.

Yang S, Shang J, Liu L, Tang Z, Meng X
Food & function 2022 Nov 28;13(23):12156-12169

Dok5 regulates proliferation and differentiation of osteoblast via canonical Wnt/β-catenin signaling.

Xu L, Wu J, Yu Y, Li H, Sun S, Zhang T, Wang M
Journal of musculoskeletal & neuronal interactions 2022 Mar 1;22(1):113-122

Identification of a novel Calpain-2-SRC feed-back loop as necessity for β-Catenin accumulation and signaling activation in hepatocellular carcinoma.

Ma XL, Zhu KY, Chen YD, Tang WG, Xie SH, Zheng H, Tong Y, Wang YC, Ren N, Guo L, Lu RQ
Oncogene 2022 Jul;41(27):3554-3569

Efficacy of auranofin as an inhibitor of desmoid progression.

Ito K, Nishida Y, Hamada S, Shimizu K, Sakai T, Ohkawara B, Alman BA, Enomoto A, Ikuta K, Koike H, Zhang J, Ohno K, Imagama S
Scientific reports 2022 Jul 13;12(1):11918

Kangxianruangan granule‑containing serum mediated inhibition of hepatic oval cell differentiation into hepatocellular carcinoma cells via the Wnt‑1/β‑catenin signaling pathway.

Tang W, Xue J, Luo L, Wang Y, Cai X, Liu Y, Huang D, Wang X, He T, Lu D, Yang F
Molecular medicine reports 2022 Feb;25(2)

Dihydroartemisinin suppresses proliferation, migration, the Wnt/β-catenin pathway and EMT via TNKS in gastric cancer.

Ma Y, Zhang P, Zhang Q, Wang X, Miao Q, Lyu X, Cui B, Ma H
Oncology letters 2021 Oct;22(4):688

TSPAN1 promotes autophagy flux and mediates cooperation between WNT-CTNNB1 signaling and autophagy via the MIR454-FAM83A-TSPAN1 axis in pancreatic cancer.

Zhou C, Liang Y, Zhou L, Yan Y, Liu N, Zhang R, Huang Y, Wang M, Tang Y, Ali DW, Wang Y, Michalak M, Chen XZ, Tang J
Autophagy 2021 Oct;17(10):3175-3195

An SETD1A/Wnt/β-catenin feedback loop promotes NSCLC development.

Wang R, Liu J, Li K, Yang G, Chen S, Wu J, Xie X, Ren H, Pang Y
Journal of experimental & clinical cancer research : CR 2021 Oct 13;40(1):318

Ultrathin 2D Titanium Carbide MXene (Ti(3) C(2) T(x) ) Nanoflakes Activate WNT/HIF-1α-Mediated Metabolism Reprogramming for Periodontal Regeneration.

Cui D, Kong N, Ding L, Guo Y, Yang W, Yan F
Advanced healthcare materials 2021 Nov;10(22):e2101215

AXIN2 Reduces the Survival of Porcine Induced Pluripotent Stem Cells (piPSCs).

Zhang R, Yu S, Shen Q, Zhao W, Zhang J, Wu X, Zhu Z, Wu X, Li N, Peng S, Hua J
International journal of molecular sciences 2021 Nov 30;22(23)

Babao Dan is a robust anti-tumor agent via inhibiting wnt/β-catenin activation and cancer cell stemness.

Xie X, Chen J, Wo D, Ma E, Ning Y, Peng J, Zhu W, Ren DN
Journal of ethnopharmacology 2021 Nov 15;280:114449

TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling.

Zhang X, Luo Y, Li Q
OncoTargets and therapy 2020;13:5819-5830

Targeted inhibition of KDM6 histone demethylases eradicates tumor-initiating cells via enhancer reprogramming in colorectal cancer.

Zhang J, Ying Y, Li M, Wang M, Huang X, Jia M, Zeng J, Ma C, Zhang Y, Li C, Wang X, Shu XS
Theranostics 2020;10(22):10016-10030

circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.

Ma Z, Han C, Xia W, Wang S, Li X, Fang P, Yin R, Xu L, Yang L
Cell death & disease 2020 May 11;11(5):356

[PARP10 Influences the Proliferation of Colorectal Carcinoma Cells, a Preliminary Study].

Wu CF, Xiao M, Wang YL, Threadgill MD, Li M, Tang Y, Lin X, Yang L, Li QS, Li X
Molekuliarnaia biologiia 2020 Mar-Apr;54(2):252-261

TRIB3 confers glioma cell stemness via interacting with β-catenin.

Lu Y, Li L, Chen L, Gao Y, Chen X, Cao Y
Environmental toxicology 2020 Jun;35(6):697-706

LncRNA PVT1 promotes gemcitabine resistance of pancreatic cancer via activating Wnt/β-catenin and autophagy pathway through modulating the miR-619-5p/Pygo2 and miR-619-5p/ATG14 axes.

Zhou C, Yi C, Yi Y, Qin W, Yan Y, Dong X, Zhang X, Huang Y, Zhang R, Wei J, Ali DW, Michalak M, Chen XZ, Tang J
Molecular cancer 2020 Jul 29;19(1):118

Long Non-Coding RNA THOR Enhances the Stem Cell-Like Traits of Triple-Negative Breast Cancer Cells Through Activating β-Catenin Signaling.

Wang B, Ye Q, Zou C
Medical science monitor : international medical journal of experimental and clinical research 2020 Jul 14;26:e923507

Oxaliplatin resistance is enhanced by saracatinib via upregulation Wnt-ABCG1 signaling in hepatocellular carcinoma.

Liao X, Song G, Xu Z, Bu Y, Chang F, Jia F, Xiao X, Ren X, Zhang M, Jia Q
BMC cancer 2020 Jan 13;20(1):31

Hierarchical activation of compartmentalized pools of AMPK depends on severity of nutrient or energy stress.

Zong Y, Zhang CS, Li M, Wang W, Wang Z, Hawley SA, Ma T, Feng JW, Tian X, Qi Q, Wu YQ, Zhang C, Ye Z, Lin SY, Piao HL, Hardie DG, Lin SC
Cell research 2019 Jun;29(6):460-473

MIR17HG-miR-18a/19a axis, regulated by interferon regulatory factor-1, promotes gastric cancer metastasis via Wnt/β-catenin signalling.

Yuan J, Tan L, Yin Z, Zhu W, Tao K, Wang G, Shi W, Gao J
Cell death & disease 2019 Jun 11;10(6):454

Design, synthesis and biological evaluation of benzoylacrylic acid shikonin ester derivatives as irreversible dual inhibitors of tubulin and EGFR.

Sun WX, Han HW, Yang MK, Wen ZL, Wang YS, Fu JY, Lu YT, Wang MY, Bao JX, Lu GH, Qi JL, Wang XM, Lin HY, Yang YH
Bioorganic & medicinal chemistry 2019 Dec 1;27(23):115153

LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.

Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y, Fan Z
Nature cell biology 2018 Oct;20(10):1134-1144

Secreted AGR2 promotes invasion of colorectal cancer cells via Wnt11-mediated non-canonical Wnt signaling.

Tian S, Hu J, Tao K, Wang J, Chu Y, Li J, Liu Z, Ding X, Xu L, Li Q, Cai M, Gao J, Shuai X, Wang G, Wang L, Wang Z
Experimental cell research 2018 Mar 15;364(2):198-207

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The AXIN2 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human AXIN2. This antibody recognizes human, mouse, rat antigen. The AXIN2 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 20540-1-AP.pdf

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