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AXIN2
Axin 2DKFZp781B0869, MGC126582
The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  20540-1-AP |
19 references | Polyclonal |
WB
EL
IHC
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| Novus Biologicals | 24830002 |
2 references | Polyclonal |
WB
EL
IHC
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| Invitrogen Antibodies | PA5-21093 |
1 references | Polyclonal |
WB
ICC
IHC
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| GeneTex | GTX31822 |
Polyclonal |
WB
EL
ICC
IHC
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| Boster Biological Technology | A01772 |
Polyclonal |
WB
EL
ICC
IHC
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