14744-1-AP

antibody from Proteintech Group

Targeting: PDHB PDHE1B

Provider product page for 14744-1-AP

Western blot

ELISA

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [36]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 14744-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14744-1-AP, RRID:AB_2162941
Product name: PDHB antibody
Antibody type: Polyclonal
Description: PDHB antibody (Cat. #14744-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PDHB protein structure - 14744-1-AP shown in red.

Submitted references TGFβ-activated PDHB promotes mitochondrial pyruvate metabolism and contributes to human endoderm differentiation via ATP-dependent BRG1.

Meng L, Lv J, Yi Y, Lan X, Yan C, Zhu L, Yang J, Jiang W
Nature communications 2026 Feb 17;17(1)

Integrative metabolomics and lipidomics reveal Jian-Pi-Yi-Shen formula improves adenine-induced CKD rats by regulating intrarenal glycolipid metabolism.

Liu X, Li H, Xu Y, Peng Y, Wu S, Ye X, Yang Y, Lu J
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 2026 Apr 1;1273:124957

CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology.

Liao SC, Kano K, Phanse S, Nguyen M, Margolis E, Fu Y, X Meng J, Moutaoufik MT, Chatterton Z, Saccon T, Broderick K, Aoki H, Simms J, Suteja FX, Sei Y, Huang EJ, McAvoy K, Manfredi G, Halliday G, Babu M, Nakamura K
Science advances 2025 Nov 14;11(46):eadu0726

Activation of PI3K-AKT pathway prevents steroid-induced osteonecrosis of the femoral head via inhibiting Cuproptosis.

Gao S, Zhu H, Chen H, Lu H, Wen M, Fan Y, Yang D, Li H
Scientific reports 2025 Mar 15;15(1):8950

Mitochondria-localized MBD2c facilitates mtDNA transcription and drug resistance.

Hao Y, Zhou Z, Liu R, Shen S, Liu H, Zhou Y, Sun Y, Mao Q, Zhang T, Li ST, Liu Z, Chu Y, Sun L, Gao P, Zhang H
Nature chemical biology 2025 Jun;21(6):926-938

Harnessing tissue-derived mitochondria-rich extracellular vesicles (Ti-mitoEVs) to boost mitochondrial biogenesis for regenerative medicine.

Lou P, Zhou X, Zhang Y, Xie Y, Wang Y, Wang C, Liu S, Wan M, Lu Y, Liu J
Science advances 2025 Jul 18;11(29):eadt1318

Isoacteoside alleviates hepatocellular carcinoma progression by inhibiting PDHB-mediated reprogramming of glucose metabolism.

Zhao L, Qi H, Liu W, Lv H, Li P, Liu W, Sun R, Wang Q, Wang X
Communications biology 2025 Feb 8;8(1):205

miR-1343-3p regulating OGDHL/PDHB-pyruvate glucose metabolic reprogramming against gastric cancer cell proliferation.

Hou X, Zhang Z, Cao M, Du Y, Wang X
Discover oncology 2025 Dec 20;17(1):139

Herbal Composition Inhibits Mitochondrial Oxidative Phosphorylation to Prevent HER2-Positive Breast Cancer and Identifies Potential Active Compounds.

Zhao Y, Hu W, Wang X, Ren Z, Gong Y, Liu L, Sun Y
International journal of molecular sciences 2025 Dec 12;26(24)

A repurposed AMP binding domain reveals mitochondrial protein AMPylation as a regulator of cellular metabolism.

Gonzalez A, Pon A, Servage K, Pawłowski K, Han Y, Sreelatha A
Nature communications 2025 Aug 23;16(1):7863

Construction and validation of a bioinformatics‑based screen for cuproptosis‑related genes and risk model for Alzheimer's disease.

Hu R, Xiao Z, Qiao M, Liu C, Wu G, Wang Y, Dong M, Huang Z
Molecular medicine reports 2024 Nov;30(5)

NOTCH1 mitochondria localization during heart development promotes mitochondrial metabolism and the endothelial-to-mesenchymal transition in mice.

Wang J, Zhao R, Xu S, Zhou XY, Cai K, Chen YL, Zhou ZY, Sun X, Shi Y, Wang F, Gui YH, Tao H, Zhao JY
Nature communications 2024 Nov 16;15(1):9945

Clinical features and molecular landscape of cuproptosis signature-related molecular subtype in gastric cancer.

Chong W, Ren H, Chen H, Xu K, Zhu X, Liu Y, Sang Y, Li H, Liu J, Ye C, Shang L, Jing C, Li L
iMeta 2024 Jun;3(3):e190

Molecular characterization and clinical relevance of metabolic signature subtypes in gastric cancer.

Chen H, Jing C, Shang L, Zhu X, Zhang R, Liu Y, Wang M, Xu K, Ma T, Jing H, Wang Z, Li X, Chong W, Li L
Cell reports 2024 Jul 23;43(7):114424

Hypoxia induces mitochondrial protein lactylation to limit oxidative phosphorylation.

Mao Y, Zhang J, Zhou Q, He X, Zheng Z, Wei Y, Zhou K, Lin Y, Yu H, Zhang H, Zhou Y, Lin P, Wu B, Yuan Y, Zhao J, Xu W, Zhao S
Cell research 2024 Jan;34(1):13-30

Analysis of the potential biological value of pyruvate dehydrogenase E1 subunit β in human cancer.

Rong Y, Liu SH, Tang MZ, Wu ZH, Ma GR, Li XF, Cai H
World journal of gastrointestinal oncology 2024 Jan 15;16(1):144-181

Bioinformatics reveals diagnostic potential of cuproptosis-related genes in the pathogenesis of sepsis.

Sun Z, Zhao Q, Zhang J, Hu Y, Qu J, Gao H, Peng Z
Heliyon 2024 Jan 15;10(1):e22664

Demystifying the landscape of endometrial immune microenvironment in luteal-phase from cuprotosis: Implications for the mechanism and treatment of RPL.

Zhao X, Wang S, Du T, Jiang Y, Zhao Y, Ma Y, Shen D, Shen Y, Ma J
Gene 2024 Apr 20;903:148191

ITGB1-mediated molecular landscape and cuproptosis phenotype induced the worse prognosis in diffuse gastric cancer.

Zhu X, Chen H, Li H, Ren H, Ye C, Xu K, Liu J, Du F, Zhang Z, Liu Y, Xie X, Wang M, Ma T, Chong W, Shang L, Li L
Frontiers in oncology 2023;13:1115510

Bioinformatics-Based Analysis of Key Genes in Steroid-Induced Osteonecrosis of the Femoral Head That Are Associated with Copper Metabolism.

Qi B, Li C, Cai X, Pu L, Guo M, Tang Z, Bu P, Xu Y
Biomedicines 2023 Mar 13;11(3)

Pyruvate dehydrogenase B regulates myogenic differentiation via the FoxP1-Arih2 axis.

Jiang X, Ji S, Yuan F, Li T, Cui S, Wang W, Ye X, Wang R, Chen Y, Zhu S
Journal of cachexia, sarcopenia and muscle 2023 Feb;14(1):606-621

PKM2-mediated neuronal hyperglycolysis enhances the risk of Parkinson's disease in diabetic rats.

Zhao Y, Wang Y, Wu Y, Tao C, Xu R, Chen Y, Qian L, Xu T, Lian X
Journal of pharmaceutical analysis 2023 Feb;13(2):187-200

Wang H, Yang Z, He X, Guo F, Sun H, Xu S, Xu C, Wang Z, Wen H, Teng Z, Wang Y, Han Z
BMC cancer 2023 Aug 28;23(1):804

Beneficial effects of aloperine on inflammation and oxidative stress by suppressing necroptosis in lipopolysaccharide-induced acute lung injury mouse model.

Cui YR, Qu F, Zhong WJ, Yang HH, Zeng J, Huang JH, Liu J, Zhang MY, Zhou Y, Guan CX
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jun;100:154074

Phosphorylation of PDHA by AMPK Drives TCA Cycle to Promote Cancer Metastasis.

Cai Z, Li CF, Han F, Liu C, Zhang A, Hsu CC, Peng D, Zhang X, Jin G, Rezaeian AH, Wang G, Zhang W, Pan BS, Wang CY, Wang YH, Wu SY, Yang SC, Hsu FC, D'Agostino RB Jr, Furdui CM, Kucera GL, Parks JS, Chilton FH, Huang CY, Tsai FJ, Pasche B, Watabe K, Lin HK
Molecular cell 2020 Oct 15;80(2):263-278.e7

Maintaining Iron Homeostasis Is the Key Role of Lysosomal Acidity for Cell Proliferation.

Weber RA, Yen FS, Nicholson SPV, Alwaseem H, Bayraktar EC, Alam M, Timson RC, La K, Abu-Remaileh M, Molina H, Birsoy K
Molecular cell 2020 Feb 6;77(3):645-655.e7

Enhanced Glycogen Metabolism Supports the Survival and Proliferation of HPV-Infected Keratinocytes in Condylomata Acuminata.

Gu Z, Zhang H, Guo X, Cao Y
The Journal of investigative dermatology 2020 Aug;140(8):1513-1523.e5

The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression.

Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, Ma K, Chang R, Liu Q, Gao R, Nie J, Xie J, Han J, Chen L, Ma G, Zhu Y, Chen Q
Nature communications 2019 Mar 4;10(1):1034

ABT737 reverses cisplatin resistance by targeting glucose metabolism of human ovarian cancer cells.

Xu Y, Gao W, Zhang Y, Wu S, Liu Y, Deng X, Xie L, Yang J, Yu H, Su J, Sun L
International journal of oncology 2018 Sep;53(3):1055-1068

Utilizing Optimized Tools to Investigate PTM Crosstalk: Identifying Potential PTM Crosstalk of Acetylated Mitochondrial Proteins.

Horita H, Law A, Middleton K
Proteomes 2018 May 22;6(2)

(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and Hepatosteatosis.

Ren L, Sun Y, Lu H, Ye D, Han L, Wang N, Daugherty A, Li F, Wang M, Su F, Tao W, Sun J, Zelcer N, Mullick AE, Danser AHJ, Jiang Y, He Y, Ruan X, Lu X
Circulation research 2018 Mar 2;122(5):730-741

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis.

Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J
Nature cell biology 2018 Feb;20(2):186-197

Pyruvate dehydrogenase has a major role in mast cell function, and its activity is regulated by mitochondrial microphthalmia transcription factor.

Sharkia I, Hadad Erlich T, Landolina N, Assayag M, Motzik A, Rachmin I, Kay G, Porat Z, Tshori S, Berkman N, Levi-Schaffer F, Razin E
The Journal of allergy and clinical immunology 2017 Jul;140(1):204-214.e8

CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.

Gu Z, Zhang H, Li Y, Shen S, Yin X, Zhang W, Cheng R, Zhang Y, Zhang X, Chen H, Huang B, Cao Y
Oncotarget 2017 Dec 26;8(69):114328-114343

Critical roles of mitochondria in brain activities of torpid Myotis ricketti bats revealed by a proteomic approach.

Zhang Y, Pan YH, Yin Q, Yang T, Dong D, Liao CC, Zhang S
Journal of proteomics 2014 Jun 13;105:266-84

Early changes in the liver-soluble proteome from mice fed a nonalcoholic steatohepatitis inducing diet.

Thomas A, Stevens AP, Klein MS, Hellerbrand C, Dettmer K, Gronwald W, Oefner PJ, Reinders J
Proteomics 2012 May;12(9):1437-51

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human heart tissue were subjected to SDS PAGE followed by western blot with 14744-1-AP(PDHB antibody) at dilution of 1:300
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PDHB antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PDHB. This antibody recognizes human,mouse,rat antigen. The PDHB antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 14744-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human skin cancer using 14744-1-AP(PDHB antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue