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Protein structure
PDHB
Pyruvate dehydrogenase E1 subunit betaPDHE1B
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]
Top validated antibodies |
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| Proteintech Group |  14744-1-AP |
22 references | Polyclonal |
WB
EL
IP
IHC
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| LSBio | LS-C133369 |
Monoclonal |
WB
EL
IHC
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| GeneTex | GTX104040 |
1 references | Polyclonal |
WB
ICC
IHC
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| Novus Biologicals | H00005162-M03 |
1 references | Monoclonal |
WB
EL
IHC
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| Abnova Corporation | H00005162-M03 |
1 references | Monoclonal |
WB
EL
IHC
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