KCND2

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels. [provided by RefSeq, Jul 2008]

Description

Potassium voltage-gated channel subfamily D member 2

Tissue specificity

Tissue enriched (brain)

Predicted location

Intracellular, Membrane

Protein family

Disease related genes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

7 (120273175 - 120750337)

Ensembl ID

ENSG00000184408  (ver. 103.38)

Orthologs

Mouse Kcnd2: ENSMUSG00000060882

UniProt

Q9NZV8

neXtProt

NX_Q9NZV8

Human splice variants
Mouse splice variants

Protein structure