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- Antibody Data
- Antigen structure
- References [141]
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- Immunohistochemistry [1]
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- Product number
- 11170-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#11170-1-AP, RRID:AB_2096489
- Product name
- EIF2S1/EIF2A antibody
- Antibody type
- Polyclonal
- Description
- EIF2S1/EIF2A antibody (Cat. #11170-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references SARS-CoV-2 Nsp15 facilitates immune evasion and viral replication by limiting multiple host innate immune pathways, including cGAS-STING.
Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction.
ATF4 Is Dispensable for Spermatogenesis but Protective Against ER Stress Under Normal Conditions.
African swine fever virus MGF_110-8L promotes host cell autophagy and suppresses interferon signaling by activating the unfolded protein response.
Rainbow trout (Oncorhynchus mykiss) G3BP1 function as an antiviral molecule against infectious hematopoietic necrosis virus infection.
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
Pharmacological Enhancement of Integrated Stress Response Confers Protection in Calcific Aortic Valve Disease.
Outer membrane vesicles secreted by avian pathogenic Escherichia coli promote its survival within macrophages and systemic infection by inducing endoplasmic reticulum stress-mediated autophagy flux blockade.
Natural killer cells aggravate neuroinflammation through microglial type I interferon pathway activation after traumatic brain injury.
Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.
The integrated stress response suppresses PINK1-dependent mitophagy by preserving mitochondrial import efficiency.
CB1 Receptor Agonist ACEA Resists ER Stress-Mediated Apoptosis via CB1R-Independent Mechanism.
Qizhi Kebitong Formula Ameliorates Sciatic Nerve Injury in Streptozocin-induced Diabetic Mice through PERK/ATF4/CHOP Endoplasmic Reticulum Stress Signaling Pathway.
Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation.
In vitro mechanical stretch inhibits differentiation of mouse myoblast C2C12 cells without sustained eIF2α phosphorylation.
Short-term high-dose gemcitabine induces PERK-mediated immunogenic cell death and potentiates antitumor immunity in bladder cancer.
Gestational exposure to micro- and nanoplastics leads to poor pregnancy outcomes by impairing placental trophoblast syncytialization.
Translation landscape of stress granules.
The EIF2α-PERK Signaling Pathway Mediates Manganese Exposure-Induced A1-Type Astrocytes Activation via Endoplasmic Reticulum Stress.
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size.
BFGF alleviates diabetic endothelial dysfunction by downregulating Endoplasmic reticulum stress.
Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia-Induced Stress Granule Formation.
Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury.
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury.
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis.
Targeting ADAR1 with a small molecule for the treatment of prostate cancer.
Aerobic exercise improves energy and glucose homeostasis through hypothalamic Mitofusion 2-rescued endoplasmic reticulum stress in diet-induced obese mice.
Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin.
Quercetin-loaded exosomes delivery system prevents myopia progression by targeting endoplasmic reticulum stress and ferroptosis in scleral fibroblasts.
The interaction between COX-2 and endoplasmic reticulum stress is involved in liver ischemia-reperfusion injury in mice.
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells.
Ribosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis.
Schisandra chinensis lignans exerts endocannabinoids-like antidepressive effect: The phagocytotic relationship of activated CB2R-mediated M2 microglia and "stressed-but-viable" neuron.
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca(2+) Imbalance.
Disruption of cerebral cholesterol homeostasis by PS-NPs: astrocytic endoplasmic reticulum stress.
Promoting astrocyte-neuron triiodothyronine shuttling attenuates brain damage in neonatal hypoxic-ischemic encephalopathy.
CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis.
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size.
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU Through Smoothing Endoplasmic Reticulum Stress-Mediated Autophagic Flux.
RNA triggers chronic stress during neuronal aging.
Isolation and Characterization of a Novel Porcine Teschovirus 2 Strain: Incomplete PERK-Mediated Unfolded Protein Response Supports Viral Replication.
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
Mitochondrial damage and ER stress in CB1 receptor antagonist-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
EIF3D safeguards the homeostasis of key signaling pathways in human primed pluripotency.
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
Critical role of G3BP1 in bovine parainfluenza virus type 3 (BPIV3)-inhibition of stress granules formation and viral replication.
Carboplatin restricts peste des petits ruminants virus replication by suppressing the STING-mediated autophagy.
Alternative splicing of ALDOA confers tamoxifen resistance in breast cancer.
Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects.
SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.
Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice.
Berberine ameliorates vascular dysfunction by downregulating TMAO-endoplasmic reticulum stress pathway via gut microbiota in hypertension.
CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction.
ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats.
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4.
The Integrated Stress Response Suppresses PINK1-dependent Mitophagy by Preserving Mitochondrial Import Efficiency.
NUS1 Variants Cause Lennox-Gastaut Syndrome Related to Unfolded Protein Reaction Activation.
Enhanced endoplasmic reticulum stress signaling disrupts porcine sertoli cell function in response to Bisphenol A exposure.
OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.
Quercetin Alleviates Scleral Remodeling Through Inhibiting the PERK-EIF2α Axis in Experiment Myopia.
Gut Microbiota Modulates Fgf21 Expression and Metabolic Phenotypes Induced by Ketogenic Diet.
Inhibition of GZMB activity ameliorates cognitive dysfunction by reducing demyelination in diabetic mice.
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2α and upregulation of tumor suppressor RBM5.
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
eIF2α-mediated integrated stress response links multiple intracellular signaling pathways to reprogram vascular smooth muscle cell fate in carotid artery plaque.
Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner.
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin.
Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice.
Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress.
Dual targeting agent Thiotert inhibits the progression of glioblastoma by inducing ER stress-dependent autophagy.
Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis.
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.
High-level L-Gln compromises intestinal amino acid utilization efficiency and inhibits protein synthesis by GCN2/eIF2α/ATF4 signaling pathway in piglets fed low-crude protein diets.
Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro.
Neutrophil extracellular traps with low concentrations induce proliferation and migration of human fibroblasts via activating CCDC25/ILK/PI3K/AKT pathway.
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis.
Maltol Improves Peripheral Nerve Function by Inhibiting Schwann Cell Apoptosis via the PERK/eIF2α/CHOP Pathway and MME Upregulation in Diabetic Peripheral Neuropathy.
The Raf kinase inhibitors Dabrafenib and Regorafenib impair Zika virus replication via distinct mechanisms.
Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway.
Liproxstatin-1 attenuates acute hypertriglyceridemic pancreatitis through inhibiting ferroptosis in rats.
SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.
Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles.
Autophagosomes Defeat Ferroptosis by Decreasing Generation and Increasing Discharge of Free Fe(2+) in Skin Repair Cells to Accelerate Diabetic Wound Healing.
Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway.
eIF3d controls the persistent integrated stress response.
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.
Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment.
Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma.
LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
Novel immunogenic cell death-related risk signature to predict prognosis and immune microenvironment in lung adenocarcinoma.
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication.
An investigation of the endoplasmic reticulum stress in obesity exposure in the prenatal period.
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells.
Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD.
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1.
Oridonin ameliorates acetaminophen-induced acute liver injury through ATF4/PGC-1α pathway.
Protective Effects of Selenium Nanoparticles against Bisphenol A-Induced Toxicity in Porcine Intestinal Epithelial Cells.
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.
Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML Cells.
Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy.
Jatrorrhizine Improves Endothelial Function in Diabetes and Obesity through Suppression of Endoplasmic Reticulum Stress.
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Benzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stress.
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia.
African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α Pathway.
Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.
Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.
STING1 is essential for an RNA-virus triggered autophagy.
Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.
The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.
EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.
Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.
Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.
Citrus alkaline extracts prevent endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway.
The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy.
HDAC6, A Novel Cargo for Autophagic Clearance of Stress Granules, Mediates the Repression of the Type I Interferon Response During Coxsackievirus A16 Infection.
Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.
ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.
Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.
Polychlorinated Biphenyl Quinone Promotes Atherosclerosis through Lipid Accumulation and Endoplasmic Reticulum Stress via CD36.
Minocycline induces apoptosis of photoreceptor cells by regulating ER stress.
Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.
Hydrogen sulphide ameliorating skeletal muscle atrophy in db/db mice via Muscle RING finger 1 S-sulfhydration.
Activating Transcription Factor 4 (ATF4)-ATF3-C/EBP Homologous Protein (CHOP) Cascade Shows an Essential Role in the ER Stress-Induced Sensitization of Tetrachlorobenzoquinone-Challenged PC12 Cells to ROS-Mediated Apoptosis via Death Receptor 5 (DR5) Signaling.
Potent effects of the total saponins from Dioscorea nipponica Makino against streptozotocin-induced type 2 diabetes mellitus in rats.
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B
The Journal of general virology 2026 Mar;107(3)
The Journal of general virology 2026 Mar;107(3)
Complement 5a receptor 2 attenuates diabetic kidney disease by promoting mitochondria-associated endoplasmic reticulum membrane formation mediated by PSS-MFN2 interaction.
Zhao YY, Wang YH, Li ZH, Chang DY, Nie L, Zhao MH, Tang SCW, Chen M
Cell discovery 2026 Mar 31;12(1)
Cell discovery 2026 Mar 31;12(1)
ATF4 Is Dispensable for Spermatogenesis but Protective Against ER Stress Under Normal Conditions.
Zhang M, Wu Z, Teng Y, Zhu H, Dai P
Biology 2026 Mar 13;15(6)
Biology 2026 Mar 13;15(6)
African swine fever virus MGF_110-8L promotes host cell autophagy and suppresses interferon signaling by activating the unfolded protein response.
Hou YP, Yang JK, Wang Y, Xia T, Wu X
Veterinary microbiology 2026 Jun;317:111013
Veterinary microbiology 2026 Jun;317:111013
Rainbow trout (Oncorhynchus mykiss) G3BP1 function as an antiviral molecule against infectious hematopoietic necrosis virus infection.
Zhao JZ, Shao YZ, Liu WT, Lu TY, Xu LM
Fish & shellfish immunology 2026 Jun;173:111275
Fish & shellfish immunology 2026 Jun;173:111275
Leveraging ANXA1 to enhance recombinant protein yields in CHO cells: A UPR-Mediated bioprocessing approach.
Zhao Q, Zhang HJ, Han MM, Abiti J, Dong YJ, Wang JN, Lu JT, Wang W, Zhang X, Geng SL, Qiu LL, Wang XY, Hua ZC, Wang TY, Jia YL
Synthetic and systems biotechnology 2026 Jun;12:197-208
Synthetic and systems biotechnology 2026 Jun;12:197-208
Pharmacological Enhancement of Integrated Stress Response Confers Protection in Calcific Aortic Valve Disease.
Wang L, Duan X, Liu H, Lin F, Zhou C, Schröder K, Shah AM, Zhao G, Zhang M
JACC. Basic to translational science 2026 Jan;11(1):101433
JACC. Basic to translational science 2026 Jan;11(1):101433
Outer membrane vesicles secreted by avian pathogenic Escherichia coli promote its survival within macrophages and systemic infection by inducing endoplasmic reticulum stress-mediated autophagy flux blockade.
Cui T, Li Z, Gao J, Miao Z, Li F, Shao Y, Wang Z, Sun J, Song X, Qi K, Tu J
Veterinary research 2026 Jan 27;57(1):34
Veterinary research 2026 Jan 27;57(1):34
Natural killer cells aggravate neuroinflammation through microglial type I interferon pathway activation after traumatic brain injury.
Nie M, Yuan J, Dong S, Gong Z, Sha Z, Liu T, Mi L, Liu X, Huang J, Jiang W, Liu M, Gao C, Jiang R
Journal of neuroinflammation 2026 Feb 2;23(1):52
Journal of neuroinflammation 2026 Feb 2;23(1):52
Brucella Omp25 activates the unfolded protein response to promote intracellular proliferation and inflammation.
Yang JK, Huang S, Hou YP, Yuan HF, Wang Y, Li M, Cao LB, Xia T, Shu HB, Wu X
The Journal of biological chemistry 2026 Apr;302(4):111333
The Journal of biological chemistry 2026 Apr;302(4):111333
The integrated stress response suppresses PINK1-dependent mitophagy by preserving mitochondrial import efficiency.
Yang M, Mo Z, Walsh K, Liu W, Irahal IN, Arnoult D, Guo X
Nature communications 2026 Apr 9;
Nature communications 2026 Apr 9;
CB1 Receptor Agonist ACEA Resists ER Stress-Mediated Apoptosis via CB1R-Independent Mechanism.
Mori K, Togo A, Ohta K, Asahi T, Nozaki C, Kataoka K
Biological & pharmaceutical bulletin 2025;48(6):769-781
Biological & pharmaceutical bulletin 2025;48(6):769-781
Qizhi Kebitong Formula Ameliorates Sciatic Nerve Injury in Streptozocin-induced Diabetic Mice through PERK/ATF4/CHOP Endoplasmic Reticulum Stress Signaling Pathway.
Yu H, Yang C, Wang G, Lv J, Li X, Qi W, Wang X
Current pharmaceutical design 2025;31(29):2370-2384
Current pharmaceutical design 2025;31(29):2370-2384
Alexidine dihydrochloride enhances the sensitivity of human hepatocellular carcinoma to disulfidptosis via ATF4-DDIT3 activation.
Li M, Xu J, Du K, Wang G, Feng Y, Liu P
Free radical biology & medicine 2025 Sep;237:585-599
Free radical biology & medicine 2025 Sep;237:585-599
In vitro mechanical stretch inhibits differentiation of mouse myoblast C2C12 cells without sustained eIF2α phosphorylation.
Mori K, Asahi T, Kataoka K, Akiyama Y
Biochemical and biophysical research communications 2025 Sep 8;778:152350
Biochemical and biophysical research communications 2025 Sep 8;778:152350
Short-term high-dose gemcitabine induces PERK-mediated immunogenic cell death and potentiates antitumor immunity in bladder cancer.
Xiong W, Liu Y, Yang H, Zhang B, Zhang X, Du Y, Wang H, Zhang X, Luo Y, Ha H, Fu Y, Zhang B, Zhang H, Lu J, Shang P, Yue Z
International immunopharmacology 2025 Sep 23;162:115057
International immunopharmacology 2025 Sep 23;162:115057
Gestational exposure to micro- and nanoplastics leads to poor pregnancy outcomes by impairing placental trophoblast syncytialization.
Cheng Y, Li Y, Zhang Y, Liu H, Yang B, Zhu J, Kuang H
Environmental pollution (Barking, Essex : 1987) 2025 Sep 15;381:126520
Environmental pollution (Barking, Essex : 1987) 2025 Sep 15;381:126520
Translation landscape of stress granules.
Wu Y, Wang X, Meng L, Liao Z, Ji W, Zhang P, Lin J, Guo Q
Science advances 2025 Oct 3;11(40):eady6859
Science advances 2025 Oct 3;11(40):eady6859
The EIF2α-PERK Signaling Pathway Mediates Manganese Exposure-Induced A1-Type Astrocytes Activation via Endoplasmic Reticulum Stress.
Wang J, Guo T, Hu Y, Zhuang C, Su P, Liu X
Toxics 2025 Oct 23;13(11)
Toxics 2025 Oct 23;13(11)
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size.
Baehr LM, de Sousa LGO, Goodman CA, Sharples AP, Waddell DS, Bodine SC, Hughes DC
bioRxiv : the preprint server for biology 2025 Oct 2;
bioRxiv : the preprint server for biology 2025 Oct 2;
BFGF alleviates diabetic endothelial dysfunction by downregulating Endoplasmic reticulum stress.
Hu F, Li J, Zhang X, Fu Y, Mao Y, Tong S, Xu H
Acta diabetologica 2025 Nov;62(11):1859-1871
Acta diabetologica 2025 Nov;62(11):1859-1871
Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia-Induced Stress Granule Formation.
Li C, Liu Z, Zhu L, Wu G, Fu C, Li H, He T, Shen M, Liu H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04896
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04896
Thymoquinone inhibited the chondrogenic differentiation of tendon-derived stem cells caused by tendon injury.
Tu YJ, Liu YQ, Pan YY, Cai HY, Liu C
World journal of stem cells 2025 Nov 26;17(11):112393
World journal of stem cells 2025 Nov 26;17(11):112393
Cinnamic acid prevents skeletal muscle atrophy in nephrectomized rats by modulating apoptosis and endoplasmic reticulum stress.
Zhang C, Wang H, He Z, He J, Wang F, Yan S, Sheng Y, Yuan N, Chen Y, Xu X, Huang Y, Hu R, Wang M, Xiao W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157499
Pharmacological targeting cGAS/STING/NF-κB axis by tryptanthrin induces microglia polarization toward M2 phenotype and promotes functional recovery in a mouse model of spinal cord injury.
Fan Z, Jia M, Zhou J, Zhu Z, Wu Y, Lin X, Qian Y, Lian J, Hua X, Dong J, Fang Z, Liu Y, Chen S, Xue X, Yue J, Zhu M, Wang Y, Huang Z, Teng H
Neural regeneration research 2025 Nov 1;20(11):3287-3301
Neural regeneration research 2025 Nov 1;20(11):3287-3301
Astragalus polysaccharide alleviates oxidative stress and senescence in chondrocytes in osteoarthritis via GCN2/ATF4/TXN axis.
Chen K, Qin C, Ji C, Yu Y, Wu Y, Xu L, Jiang Y, Zou G
International journal of biological macromolecules 2025 May;310(Pt 3):143285
International journal of biological macromolecules 2025 May;310(Pt 3):143285
Targeting ADAR1 with a small molecule for the treatment of prostate cancer.
Wang X, Li J, Zhu Y, Shen H, Ding J, Zeng T, Min W, Liang SQ, Huang L, Shi Z, Shen H, Huang F, Yuan K, Kuang W, Ji M, Sun C, Hou Y, Wang L, Chen W, Jiang Y, Hao H, Xiao Y, Yang P
Nature cancer 2025 Mar;6(3):474-492
Nature cancer 2025 Mar;6(3):474-492
Aerobic exercise improves energy and glucose homeostasis through hypothalamic Mitofusion 2-rescued endoplasmic reticulum stress in diet-induced obese mice.
Zhang S, Chen Y, Yang R, Ye L, Chen H, Jiang L, Bai D, Wu D
Diabetes, obesity & metabolism 2025 Mar;27(3):1251-1264
Diabetes, obesity & metabolism 2025 Mar;27(3):1251-1264
Mitochondrial ROS-associated integrated stress response is involved in arsenic-induced blood-testis barrier disruption and protective effect of melatonin.
Niu FW, Liu MD, Yao K, Yang R, Gao L, Zhai JX, Wang C, Zhang SH, Xu DX, Zhang ZH
Environment international 2025 Mar;197:109346
Environment international 2025 Mar;197:109346
Quercetin-loaded exosomes delivery system prevents myopia progression by targeting endoplasmic reticulum stress and ferroptosis in scleral fibroblasts.
Zhao L, Dong X, Guo B, Song J, Bi H
Materials today. Bio 2025 Jun;32:101896
Materials today. Bio 2025 Jun;32:101896
The interaction between COX-2 and endoplasmic reticulum stress is involved in liver ischemia-reperfusion injury in mice.
Liang C, Guo L, Tian X, Mu Z, Chen M, Hu Y, Su J
Molecular biology reports 2025 Jul 15;52(1):710
Molecular biology reports 2025 Jul 15;52(1):710
PRDX4 mitigates diabetic retinopathy by inhibiting reactive gliosis, apoptosis, ER stress, oxidative stress, and mitochondrial dysfunction in Müller cells.
Huang Y, Zhang Y, Liu Y, Jin Y, Yang H
The Journal of biological chemistry 2025 Jan;301(1):108111
The Journal of biological chemistry 2025 Jan;301(1):108111
Ribosome customization and functional diversification among P-stalk proteins regulate late poxvirus protein synthesis.
Khalatyan N, Cornish D, Ferrell AJ, Savas JN, Shen PS, Hultquist JF, Walsh D
Cell reports 2025 Jan 28;44(1):115119
Cell reports 2025 Jan 28;44(1):115119
Schisandra chinensis lignans exerts endocannabinoids-like antidepressive effect: The phagocytotic relationship of activated CB2R-mediated M2 microglia and "stressed-but-viable" neuron.
Wang J, Du H, Li M, Yan T, Jia Y
Journal of ethnopharmacology 2025 Feb 27;342:119385
Journal of ethnopharmacology 2025 Feb 27;342:119385
In vitro analysis of the molecular mechanisms of ursolic acid against ovarian cancer.
Zhang R, Zhang Z, Xie L, Yu Z, Gao R, Zhang ZR, Zhang Y, Wei X, Chen Y, Jiao S, Gao Y, Guo JP
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
BMC complementary medicine and therapies 2025 Feb 21;25(1):65
Metformin Ameliorates Early Brain Injury After Subarachnoid Hemorrhage Via Improving Endoplasmic Reticulum Stress and Mitochondrial Stress-Mediated Ca(2+) Imbalance.
Zhang Z, Zhang J, Li L, Zong L
Molecular neurobiology 2025 Dec 5;63(1):256
Molecular neurobiology 2025 Dec 5;63(1):256
Disruption of cerebral cholesterol homeostasis by PS-NPs: astrocytic endoplasmic reticulum stress.
Tian L, Wei Y, Ma J, Zhao Y, Mi Y, Zhang L, Wang B, Chen J, Li K, Shi Y, Lai W, Liu H, Lin B
Journal of nanobiotechnology 2025 Dec 24;23(1):790
Journal of nanobiotechnology 2025 Dec 24;23(1):790
Promoting astrocyte-neuron triiodothyronine shuttling attenuates brain damage in neonatal hypoxic-ischemic encephalopathy.
Yu G, Yang Y, Zhou W, Wang X, Feng Y, Wang X, Lin Z
Journal of neuroinflammation 2025 Dec 2;23(1):5
Journal of neuroinflammation 2025 Dec 2;23(1):5
CEBPD-mediated SGPP2 upregulation via PERK/ER stress in endothelial cells disrupts S1P homeostasis and impairs angiogenesis in chronic endometritis.
Wang Y, Chen X, You G, Yu S, Chen C, Lian R, Diao L, Li Y, Yin T
Journal of translational medicine 2025 Dec 17;24(1):98
Journal of translational medicine 2025 Dec 17;24(1):98
Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size.
Baehr LM, Oliveira de Sousa LG, Goodman CA, Sharples AP, Waddell DS, Bodine SC, Hughes DC
American journal of physiology. Cell physiology 2025 Dec 1;329(6):C1706-C1722
American journal of physiology. Cell physiology 2025 Dec 1;329(6):C1706-C1722
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
Wu D, Li M, Hong Y, Jin L, Liu Q, Sun C, Li L, Han X, Deng S, Feng Y, Shen Y, Kai G
Journal of advanced research 2025 Aug;74:621-635
Journal of advanced research 2025 Aug;74:621-635
Berberine Enhances the Sensitivity of Colorectal Cancer Cells to 5-FU Through Smoothing Endoplasmic Reticulum Stress-Mediated Autophagic Flux.
Xu J, Hu M, Li Y, Gong H, Zhang X, He Z, Xiao C, Yang C, Zeng J
Cell biology international 2025 Aug;49(8):1042-1055
Cell biology international 2025 Aug;49(8):1042-1055
RNA triggers chronic stress during neuronal aging.
Rhine K, Epstein E, Carlson NM, Ge X, Mizrahi O, Kamat A, Hermann A, Brothers WR, Ravits J, Bennett EJ, Pekkurnaz G, Yeo GW
bioRxiv : the preprint server for biology 2025 Aug 5;
bioRxiv : the preprint server for biology 2025 Aug 5;
Isolation and Characterization of a Novel Porcine Teschovirus 2 Strain: Incomplete PERK-Mediated Unfolded Protein Response Supports Viral Replication.
Feng X, Du Y, Lv Y, Wei X, Cui C, Qin Y, Lu B, Chen Z, Ouyang K, Chen Y, Wei Z, Huang W, He Y, Qin Y
Viruses 2025 Aug 31;17(9)
Viruses 2025 Aug 31;17(9)
Targeting the SYVN1-EGFR axis: a breakthrough strategy for TKI-resistant NSCLC.
Xie X, Tong W, Xie Y, Jiang H, Jiang A, Huang J, Liu Z, Yu J
Cell death & disease 2025 Aug 28;16(1):655
Cell death & disease 2025 Aug 28;16(1):655
Mitochondrial damage and ER stress in CB1 receptor antagonist-induced apoptosis in human neuroblastoma SH-SY5Y cells.
Mori K, Togo A, Yamashita K, Sakuragi S, Bannai H, Umezawa T, Ohta K, Asahi T, Nozaki C, Kataoka K
Neuropharmacology 2025 Aug 1;273:110440
Neuropharmacology 2025 Aug 1;273:110440
Klotho improves Der p1-induced bronchial epithelial cell damage by inhibiting endoplasmic reticulum stress to regulate mitochondrial function.
Wang C, Liu Z, Xie X, Li Y, Sun L
Tissue & cell 2025 Apr;93:102646
Tissue & cell 2025 Apr;93:102646
EIF3D safeguards the homeostasis of key signaling pathways in human primed pluripotency.
Okubo C, Nakamura M, Sato M, Shichino Y, Mito M, Takashima Y, Iwasaki S, Takahashi K
Science advances 2025 Apr 11;11(15):eadq5484
Science advances 2025 Apr 11;11(15):eadq5484
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.
Liu Y, Cui F, Xu A, Wang B, Ma Y, Zhang Q, Sun Q, Zheng Y, Xue Y, Sun Y, Bian L
International journal of biological sciences 2024;20(11):4277-4296
International journal of biological sciences 2024;20(11):4277-4296
Critical role of G3BP1 in bovine parainfluenza virus type 3 (BPIV3)-inhibition of stress granules formation and viral replication.
Liu N, Yang W, Luo L, Ma M, Cui J, Dong X, Li Y
Frontiers in immunology 2024;15:1358036
Frontiers in immunology 2024;15:1358036
Carboplatin restricts peste des petits ruminants virus replication by suppressing the STING-mediated autophagy.
Zhang R, Hu Z, Wei D, Li R, Li Y, Zhang Z
Frontiers in veterinary science 2024;11:1383927
Frontiers in veterinary science 2024;11:1383927
Alternative splicing of ALDOA confers tamoxifen resistance in breast cancer.
Yu S, Wu R, Si Y, Fan Z, Wang Y, Yao C, Sun R, Xue Y, Chen Y, Wang Z, Dong S, Wang N, Ling X, Liang Z, Bi C, Yang Y, Dong W, Sun H
Oncogene 2024 Sep;43(39):2901-2913
Oncogene 2024 Sep;43(39):2901-2913
Discovery of novel quinoline scaffold selective estrogen receptor degraders (SERDs) for treatment of ER positive breast cancer with enhanced antiproliferative bioactivity through immunogenic cell death (ICD) effects.
Lu Y, Liang Z, Liu L, Zhou Y, Liu C, Zhao Z, Zheng T, Du Q, Liu W
European journal of medicinal chemistry 2024 Sep 5;275:116534
European journal of medicinal chemistry 2024 Sep 5;275:116534
SARS-CoV-2 Nsp15 antagonizes the cGAS-STING-mediated antiviral innate immune responses.
Chiu HP, Yeo YY, Lai TY, Hung CT, Kowdle S, Haas GD, Jiang S, Sun W, Lee B
bioRxiv : the preprint server for biology 2024 Sep 5;
bioRxiv : the preprint server for biology 2024 Sep 5;
Melatonin Protects Against Mitochondrial Dyshomeostasis and Ovarian Damage Caused by Chronic Unpredictable Mild Stress Through the eIF2α-AFT4 Signaling Pathway in Mice.
Ding SM, Shi LG, Xing F, Cui SS, Cheng HR, Liu Y, Ji DM, Liang D, Cao YX, Liu YJ
Reproductive sciences (Thousand Oaks, Calif.) 2024 Oct;31(10):3191-3201
Reproductive sciences (Thousand Oaks, Calif.) 2024 Oct;31(10):3191-3201
Berberine ameliorates vascular dysfunction by downregulating TMAO-endoplasmic reticulum stress pathway via gut microbiota in hypertension.
Wang Z, Shao Y, Wu F, Luo D, He G, Liang J, Quan X, Chen X, Xia W, Chen Y, Liu Y, Chen L
Microbiological research 2024 Oct;287:127824
Microbiological research 2024 Oct;287:127824
CaMKII suppresses proteotoxicity by phosphorylating BAG3 in response to proteasomal dysfunction.
Zhang C, Xu H, Tang Q, Duan Y, Xia H, Huang H, Ye D, Bi F
EMBO reports 2024 Oct;25(10):4488-4514
EMBO reports 2024 Oct;25(10):4488-4514
ISRIB ameliorates spatial learning and memory impairment induced by adolescent intermittent ethanol exposure in adult male rats.
Jia W, Li C, Chen H, Wang X, Liu Y, Shang W, Wang B, Meng W, Guo Y, Zhu L, Wang D, Zhou D, Zhao B, Wei L
Neurochemistry international 2024 Oct;179:105834
Neurochemistry international 2024 Oct;179:105834
Gut microbiota-derived acetic acids promoted sepsis-induced acute respiratory distress syndrome by delaying neutrophil apoptosis through FABP4.
Xuan W, Wu X, Zheng L, Jia H, Zhang X, Zhang X, Cao B
Cellular and molecular life sciences : CMLS 2024 Oct 25;81(1):438
Cellular and molecular life sciences : CMLS 2024 Oct 25;81(1):438
The Integrated Stress Response Suppresses PINK1-dependent Mitophagy by Preserving Mitochondrial Import Efficiency.
Yang M, Mo Z, Walsh K, Liu W, Guo X
bioRxiv : the preprint server for biology 2024 Oct 17;
bioRxiv : the preprint server for biology 2024 Oct 17;
NUS1 Variants Cause Lennox-Gastaut Syndrome Related to Unfolded Protein Reaction Activation.
Shen NX, Qu XC, Yu J, Fan CX, Min FL, Li LY, Zhang MR, Li BM, Wang J, He N, Liao WP, Shi YW, Li WB
Molecular neurobiology 2024 Nov;61(11):8518-8530
Molecular neurobiology 2024 Nov;61(11):8518-8530
Enhanced endoplasmic reticulum stress signaling disrupts porcine sertoli cell function in response to Bisphenol A exposure.
Hu T, Zhang J, Wei Y, Zhang L, Wu Q
Journal of environmental management 2024 Nov;370:122908
Journal of environmental management 2024 Nov;370:122908
OBHSA, a novel selective estrogen receptor degrader, overcomes tamoxifen resistance through cell cycle arrest and unfolded protein response-mediated apoptosis in breast cancer.
Shen R, Zhou J, Xin L, Zhou HB, Huang J
The Journal of steroid biochemistry and molecular biology 2024 Nov;244:106599
The Journal of steroid biochemistry and molecular biology 2024 Nov;244:106599
Quercetin Alleviates Scleral Remodeling Through Inhibiting the PERK-EIF2α Axis in Experiment Myopia.
Zhang M, Zhang R, Hao J, Zhao X, Ma Z, Peng Y, Bao B, Xin J, Yin X, Bi H, Guo D
Investigative ophthalmology & visual science 2024 Nov 4;65(13):11
Investigative ophthalmology & visual science 2024 Nov 4;65(13):11
Gut Microbiota Modulates Fgf21 Expression and Metabolic Phenotypes Induced by Ketogenic Diet.
Wei X, Lu Y, Hong S
Nutrients 2024 Nov 25;16(23)
Nutrients 2024 Nov 25;16(23)
Inhibition of GZMB activity ameliorates cognitive dysfunction by reducing demyelination in diabetic mice.
Yang ZZ, Liu WQ, Yu HD, Yu SX, Li YR, Wang YF, Yao TF, Li WZ, Sun D, Niu L, Liu XZ, Zuo ZF
Free radical biology & medicine 2024 Nov 20;225:53-62
Free radical biology & medicine 2024 Nov 20;225:53-62
Fucoxanthin ameliorates endoplasmic reticulum stress and inhibits apoptosis and alleviates intervertebral disc degeneration in rats by upregulating Sirt1.
Teng C, Wu J, Zhang Z, Wang J, Yang Y, Dong C, Wu L, Lin Z, Hu Y, Wang J, Zhang X, Lin Z
Phytotherapy research : PTR 2024 May;38(5):2114-2127
Phytotherapy research : PTR 2024 May;38(5):2114-2127
CHIP suppresses the proliferation and migration of A549 cells by mediating the ubiquitination of eIF2α and upregulation of tumor suppressor RBM5.
Jin B, Wang M, Sun Y, Lee PAH, Zhang X, Lu Y, Zhao B
The Journal of biological chemistry 2024 Mar;300(3):105673
The Journal of biological chemistry 2024 Mar;300(3):105673
AURKA emerges as a vulnerable target for KEAP1-deficient non-small cell lung cancer by activation of asparagine synthesis.
Deng B, Liu F, Chen N, Li X, Lei J, Chen N, Wu J, Wang X, Lu J, Fang M, Chen A, Zhang Z, He B, Yan M, Zhang Y, Wang Z, Liu Q
Cell death & disease 2024 Mar 23;15(3):233
Cell death & disease 2024 Mar 23;15(3):233
eIF2α-mediated integrated stress response links multiple intracellular signaling pathways to reprogram vascular smooth muscle cell fate in carotid artery plaque.
Luo J, Zhang X, Li W, Wang T, Cui S, Li T, Wang Y, Xu W, Ma Y, Yang B, Luo Y, Yang G, Xu R, Jiao L
Heliyon 2024 Mar 15;10(5):e26904
Heliyon 2024 Mar 15;10(5):e26904
Infectious bursal disease virus VP5 triggers host shutoff in a transcription-dependent manner.
Niu X, Han J, Huang M, Wang G, Zhang Y, Zhang W, Yu H, Xu M, Li K, Gao L, Wang S, Chen Y, Cui H, Zhang Y, Liu C, Wang X, Gao Y, Qi X
mBio 2024 Mar 13;15(3):e0343323
mBio 2024 Mar 13;15(3):e0343323
Pseudorabies virus manipulates mitochondrial tryptophanyl-tRNA synthetase 2 for viral replication.
Li XQ, Cai MP, Wang MY, Shi BW, Yang GY, Wang J, Chu BB, Ming SL
Virologica Sinica 2024 Jun;39(3):403-413
Virologica Sinica 2024 Jun;39(3):403-413
Evaluation of Cross-Talk and Alleviate Potential of Cytotoxic Factors Induced by Deoxynivalenol in IPEC-J2 Cells Interference with Curcumin.
Wang Q, Li A, Yu H, Wang C, Wang T, Zhang J
International journal of molecular sciences 2024 Jun 26;25(13)
International journal of molecular sciences 2024 Jun 26;25(13)
Inhibition of endoplasmic reticulum stress attenuates morphine protracted abstinence-induced anxiety-like behaviors in the male mice.
Liu L, Wu J, Zhang C, Cao T, Lu Y, He Z, Li Z
Brain research 2024 Jul 15;1835:148930
Brain research 2024 Jul 15;1835:148930
Copper exposure induces mitochondrial dysfunction and hepatotoxicity via the induction of oxidative stress and PERK/ATF4 -mediated endoplasmic reticulum stress.
Li M, Tang S, Velkov T, Shen J, Dai C
Environmental pollution (Barking, Essex : 1987) 2024 Jul 1;352:124145
Environmental pollution (Barking, Essex : 1987) 2024 Jul 1;352:124145
Dual targeting agent Thiotert inhibits the progression of glioblastoma by inducing ER stress-dependent autophagy.
Dong J, Qian Y, Zhang W, Wang Q, Jia M, Yue J, Fan Z, Jiang Y, Wang L, Wang Y, Huang Z, Yu L, Wang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115867
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Jan;170:115867
Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis.
Zhang P, Zhou C, Ren X, Jing Q, Gao Y, Yang C, Shen Y, Zhou Y, Hu W, Jin F, Xu H, Yu L, Liu Y, Tong X, Li Y, Wang Y, Du J
Redox biology 2024 Feb;69:103007
Redox biology 2024 Feb;69:103007
Protein phosphatase 1 regulatory subunit 15 A promotes translation initiation and induces G2M phase arrest during cuproptosis in cancers.
Liu C, Chen L, Cong Y, Cheng L, Shuai Y, Lv F, Chen K, Song Y, Xing Y
Cell death & disease 2024 Feb 16;15(2):149
Cell death & disease 2024 Feb 16;15(2):149
METTL16 promotes liver cancer stem cell self-renewal via controlling ribosome biogenesis and mRNA translation.
Xue M, Dong L, Zhang H, Li Y, Qiu K, Zhao Z, Gao M, Han L, Chan AKN, Li W, Leung K, Wang K, Pokharel SP, Qing Y, Liu W, Wang X, Ren L, Bi H, Yang L, Shen C, Chen Z, Melstrom L, Li H, Timchenko N, Deng X, Huang W, Rosen ST, Tian J, Xu L, Diao J, Chen CW, Chen J, Shen B, Chen H, Su R
Journal of hematology & oncology 2024 Feb 1;17(1):7
Journal of hematology & oncology 2024 Feb 1;17(1):7
High-level L-Gln compromises intestinal amino acid utilization efficiency and inhibits protein synthesis by GCN2/eIF2α/ATF4 signaling pathway in piglets fed low-crude protein diets.
Li J, Chen Y, Yang Y, Yang Y, Wu Z
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Dec;19:480-487
Animal nutrition (Zhongguo xu mu shou yi xue hui) 2024 Dec;19:480-487
Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro.
Tao L, Liu Z, Li X, Wang H, Wang Y, Zhou D, Zhang H
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167459
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167459
Neutrophil extracellular traps with low concentrations induce proliferation and migration of human fibroblasts via activating CCDC25/ILK/PI3K/AKT pathway.
Chu Z, Zheng Y, Shen Q, Yang K, Wang H, Ma K, Hao Y, Chen J, Li H, Fu X, Zhang C
Biochemical and biophysical research communications 2024 Dec 17;738:150954
Biochemical and biophysical research communications 2024 Dec 17;738:150954
Phenylalanine deprivation inhibits multiple myeloma progression by perturbing endoplasmic reticulum homeostasis.
Cheng L, Wang X, Liu A, Zhu Y, Cheng H, Yu J, Gong L, Liu H, Shen G, Liu L
Acta pharmaceutica Sinica. B 2024 Aug;14(8):3493-3512
Acta pharmaceutica Sinica. B 2024 Aug;14(8):3493-3512
Maltol Improves Peripheral Nerve Function by Inhibiting Schwann Cell Apoptosis via the PERK/eIF2α/CHOP Pathway and MME Upregulation in Diabetic Peripheral Neuropathy.
Li J, Liu Q, Liu S, Xin H, Zhang X, Guo N
Pharmaceuticals (Basel, Switzerland) 2024 Aug 29;17(9)
Pharmaceuticals (Basel, Switzerland) 2024 Aug 29;17(9)
The Raf kinase inhibitors Dabrafenib and Regorafenib impair Zika virus replication via distinct mechanisms.
Wilken L, Rimmelzwaan GF, Elbahesh H
Journal of virology 2024 Aug 20;98(8):e0061824
Journal of virology 2024 Aug 20;98(8):e0061824
Cetylpyridinium chloride triggers paraptosis to suppress pancreatic tumor growth via the ERN1-MAP3K5-p38 pathway.
Tang H, Chen F, Gao W, Cai X, Lin Z, Kang R, Tang D, Liu J
iScience 2024 Aug 16;27(8):110598
iScience 2024 Aug 16;27(8):110598
Liproxstatin-1 attenuates acute hypertriglyceridemic pancreatitis through inhibiting ferroptosis in rats.
Xiang X, Xu M, Liu L, Meng N, Lei Y, Feng Y, Tang G
Scientific reports 2024 Apr 25;14(1):9548
Scientific reports 2024 Apr 25;14(1):9548
SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.
Wang F, Wang L, Gan S, Feng S, Ouyang S, Wang X, Yuan S
Research (Washington, D.C.) 2023;6:0091
Research (Washington, D.C.) 2023;6:0091
Novel neutrophil extracellular trap-related mechanisms in diabetic wounds inspire a promising treatment strategy with hypoxia-challenged small extracellular vesicles.
Chu Z, Huang Q, Ma K, Liu X, Zhang W, Cui S, Wei Q, Gao H, Hu W, Wang Z, Meng S, Tian L, Li H, Fu X, Zhang C
Bioactive materials 2023 Sep;27:257-270
Bioactive materials 2023 Sep;27:257-270
Autophagosomes Defeat Ferroptosis by Decreasing Generation and Increasing Discharge of Free Fe(2+) in Skin Repair Cells to Accelerate Diabetic Wound Healing.
Cui S, Liu X, Liu Y, Hu W, Ma K, Huang Q, Chu Z, Tian L, Meng S, Su J, Zhang W, Li H, Fu X, Zhang C
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300414
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Sep;10(25):e2300414
Panobinostat (LBH589) combined with AM1241 induces cervical cancer cell apoptosis through autophagy pathway.
Sheng B, Wang W, Xia D, Qu X
BMC pharmacology & toxicology 2023 Sep 22;24(1):45
BMC pharmacology & toxicology 2023 Sep 22;24(1):45
eIF3d controls the persistent integrated stress response.
Mukhopadhyay S, Amodeo ME, Lee ASY
Molecular cell 2023 Sep 21;83(18):3303-3313.e6
Molecular cell 2023 Sep 21;83(18):3303-3313.e6
Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.
Fu Y, Sacco O, DeBitetto E, Kanshin E, Ueberheide B, Sfeir A
Molecular cell 2023 Oct 19;83(20):3740-3753.e9
Molecular cell 2023 Oct 19;83(20):3740-3753.e9
Loss of ADAR1 in macrophages in combination with interferon gamma suppresses tumor growth by remodeling the tumor microenvironment.
Lin W, Luo Y, Wu J, Zhang H, Jin G, Guo C, Zhou H, Liang H, Xu X
Journal for immunotherapy of cancer 2023 Nov;11(11)
Journal for immunotherapy of cancer 2023 Nov;11(11)
Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma.
Huang Y, Yan H, Zhang B, Zhu G, Yu J, Xiao X, He W, Chen Y, Gao X, She Z, Li M, Yuan J
Marine drugs 2023 Nov 21;21(12)
Marine drugs 2023 Nov 21;21(12)
LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.
Chen L, Sun K, Qin W, Huang B, Wu C, Chen J, Lai Q, Wang X, Zhou R, Li A, Liu S, Zhang Y
Cancer letters 2023 Nov 1;576:216420
Cancer letters 2023 Nov 1;576:216420
Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.
Hou XX, Li YW, Song JL, Zhang W, Liu R, Yuan H, Feng TT, Jiang ZY, Li WT, Zhu CL
World journal of gastroenterology 2023 May 7;29(17):2616-2627
World journal of gastroenterology 2023 May 7;29(17):2616-2627
Novel immunogenic cell death-related risk signature to predict prognosis and immune microenvironment in lung adenocarcinoma.
Li Q, Tang Y, Wang T, Zhu J, Zhou Y, Shi J
Journal of cancer research and clinical oncology 2023 Jan;149(1):307-323
Journal of cancer research and clinical oncology 2023 Jan;149(1):307-323
The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.
Li Y, She W, Guo T, Huang T, Liu Y, Liu P, Xu X, Wang X, Wang M, Yu C, Liu Y, Wei Y
Biochemical pharmacology 2023 Feb;208:115404
Biochemical pharmacology 2023 Feb;208:115404
Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication.
Ramnani B, Powell S, Shetty AG, Manivannan P, Hibbard BR, Leaman DW, Malathi K
Viruses 2023 Feb 7;15(2)
Viruses 2023 Feb 7;15(2)
An investigation of the endoplasmic reticulum stress in obesity exposure in the prenatal period.
Tüfekci KK, Tatar M, Terzi F, Bakirhan EG
Journal of chemical neuroanatomy 2023 Dec;134:102348
Journal of chemical neuroanatomy 2023 Dec;134:102348
Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.
Xie F, Qu J, Lin D, Feng K, Tan M, Liao H, Zeng L, Xiong Q, Huang J, Chen W
Molecular biology reports 2023 Dec 12;51(1):10
Molecular biology reports 2023 Dec 12;51(1):10
XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells.
Cui Z, Qin R, Feng J, Liu Y, Zhou X, Qin X, Li Y, Zhang Z, He X
Tissue & cell 2023 Aug;83:102139
Tissue & cell 2023 Aug;83:102139
Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD.
Cui X, Yao M, Feng Y, Li C, Li Y, Guo D, He S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23027
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23027
Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1.
Wu S, Lu D, Gajendran B, Hu Q, Zhang J, Wang S, Han M, Xu Y, Shen X
Phytotherapy research : PTR 2023 Aug;37(8):3543-3558
Phytotherapy research : PTR 2023 Aug;37(8):3543-3558
Oridonin ameliorates acetaminophen-induced acute liver injury through ATF4/PGC-1α pathway.
Yu D, Li J, Wang Y, Guo D, Zhang X, Chen M, Zhou Z
Drug development research 2023 Apr;84(2):211-225
Drug development research 2023 Apr;84(2):211-225
Protective Effects of Selenium Nanoparticles against Bisphenol A-Induced Toxicity in Porcine Intestinal Epithelial Cells.
Pan Z, Huang J, Hu T, Zhang Y, Zhang L, Zhang J, Cui D, Li L, Wang J, Wu Q
International journal of molecular sciences 2023 Apr 14;24(8)
International journal of molecular sciences 2023 Apr 14;24(8)
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Li J, Bai J, Si X, Jia H, Wu Z
Chemico-biological interactions 2023 Apr 1;374:110386
Chemico-biological interactions 2023 Apr 1;374:110386
Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.
Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug design, development and therapy 2022;16:1713-1729
Drug design, development and therapy 2022;16:1713-1729
C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.
Zheng W, Wang K, Wu Y, Yan G, Zhang C, Li Z, Wang L, Chen S
Theranostics 2022;12(17):7289-7306
Theranostics 2022;12(17):7289-7306
Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML Cells.
Sun YN, Ma YN, Jia XQ, Yao Q, Chen JP, Li H
Current medical science 2022 Oct;42(5):958-965
Current medical science 2022 Oct;42(5):958-965
Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy.
Zhang R, Lin H, You Q, Zhang Z, Bai L, Chen F, Zhu X, Zhang Z, Li Y
Journal of virology 2022 Oct 26;96(20):e0137522
Journal of virology 2022 Oct 26;96(20):e0137522
Jatrorrhizine Improves Endothelial Function in Diabetes and Obesity through Suppression of Endoplasmic Reticulum Stress.
Zhou Y, Wang Y, Vong CT, Zhu Y, Xu B, Ruan CC, Wang Y, Cheang WS
International journal of molecular sciences 2022 Oct 11;23(20)
International journal of molecular sciences 2022 Oct 11;23(20)
Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.
Peng S, Zhao D, Li Q, Wang M, Zhang S, Pang K, Huang J, Lu F, Chen H, Zhang W
Cells 2022 Nov 2;11(21)
Cells 2022 Nov 2;11(21)
Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.
Li T, Chen Y, Tan P, Shi H, Huang Z, Cai T, Cheng Y, Du Y, Fu W
Bioorganic chemistry 2022 May;122:105737
Bioorganic chemistry 2022 May;122:105737
Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.
Chang L, Liu X, Chen J, Liu H, Wang G, Wang G, Liao X, Shen X
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597
Benzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stress.
Chen KY, Chen YJ, Cheng CJ, Jhan KY, Wang LC
Biomolecules 2022 Jan 21;12(2)
Biomolecules 2022 Jan 21;12(2)
Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.
Huang Y, Chen S, Pang L, Feng Z, Su H, Zhu W, Wei J
European journal of pharmacology 2022 Feb 15;917:174749
European journal of pharmacology 2022 Feb 15;917:174749
African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.
Wang Q, Zhou L, Wang J, Su D, Li D, Du Y, Yang G, Zhang G, Chu B
Viruses 2022 Feb 15;14(2)
Viruses 2022 Feb 15;14(2)
c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia.
Liu S, Qiao X, Wu S, Gai Y, Su Y, Edwards H, Wang Y, Lin H, Taub JW, Wang G, Ge Y
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):913-928
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):913-928
African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α Pathway.
Zhong H, Fan S, Du Y, Zhang Y, Zhang A, Jiang D, Han S, Wan B, Zhang G
Microbiology spectrum 2022 Dec 21;10(6):e0328222
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human stomach tissue were subjected to SDS PAGE followed by western blot with 11170-1-AP(EIF2S1 antibody) at dilution of 1:500
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using EIF2S1 antibody 11170-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 11170-1-AP(EIF2S1 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
