11170-1-AP

antibody from Proteintech Group

Targeting: EIF2S1 EIF-2alpha, EIF2, EIF2A

Provider product page for 11170-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [68]
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Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [1]

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Product number: 11170-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11170-1-AP, RRID:AB_2096489
Product name: EIF2S1/EIF2A antibody
Antibody type: Polyclonal
Description: EIF2S1/EIF2A antibody (Cat. #11170-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

EIF2S1 protein structure - 11170-1-AP shown in red.

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eIF3d controls the persistent integrated stress response.

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Mitochondrial DNA breaks activate an integrated stress response to reestablish homeostasis.

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LIMK1 m(6)A-RNA methylation recognized by YTHDC2 induces 5-FU chemoresistance in colorectal cancer via endoplasmic reticulum stress and stress granule formation.

Chen L, Sun K, Qin W, Huang B, Wu C, Chen J, Lai Q, Wang X, Zhou R, Li A, Liu S, Zhang Y
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Cryptotanshinone induces apoptosis of activated hepatic stellate cells via modulating endoplasmic reticulum stress.

Hou XX, Li YW, Song JL, Zhang W, Liu R, Yuan H, Feng TT, Jiang ZY, Li WT, Zhu CL
World journal of gastroenterology 2023 May 7;29(17):2616-2627

Novel immunogenic cell death-related risk signature to predict prognosis and immune microenvironment in lung adenocarcinoma.

Li Q, Tang Y, Wang T, Zhu J, Zhou Y, Shi J
Journal of cancer research and clinical oncology 2023 Jan;149(1):307-323

The organic arsenical-derived thioredoxin and glutathione system inhibitor ACZ2 induces apoptosis and autophagy in gastric cancer via ROS-dependent ER stress.

Li Y, She W, Guo T, Huang T, Liu Y, Liu P, Xu X, Wang X, Wang M, Yu C, Liu Y, Wei Y
Biochemical pharmacology 2023 Feb;208:115404

Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication.

Ramnani B, Powell S, Shetty AG, Manivannan P, Hibbard BR, Leaman DW, Malathi K
Viruses 2023 Feb 7;15(2)

An investigation of the endoplasmic reticulum stress in obesity exposure in the prenatal period.

Tüfekci KK, Tatar M, Terzi F, Bakirhan EG
Journal of chemical neuroanatomy 2023 Dec;134:102348

Reduced Proteolipid Protein 2 promotes endoplasmic reticulum stress-related apoptosis and increases drug sensitivity in acute myeloid leukemia.

Xie F, Qu J, Lin D, Feng K, Tan M, Liao H, Zeng L, Xiong Q, Huang J, Chen W
Molecular biology reports 2023 Dec 12;51(1):10

XBP1s gene of endoplasmic reticulum stress enhances proliferation and osteogenesis of human periodontal ligament cells.

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Exogenous hydrogen sulfide alleviates hepatic endoplasmic reticulum stress via SIRT1/FoxO1/PCSK9 pathway in NAFLD.

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23027

Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1.

Wu S, Lu D, Gajendran B, Hu Q, Zhang J, Wang S, Han M, Xu Y, Shen X
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Oridonin ameliorates acetaminophen-induced acute liver injury through ATF4/PGC-1α pathway.

Yu D, Li J, Wang Y, Guo D, Zhang X, Chen M, Zhou Z
Drug development research 2023 Apr;84(2):211-225

Protective Effects of Selenium Nanoparticles against Bisphenol A-Induced Toxicity in Porcine Intestinal Epithelial Cells.

Pan Z, Huang J, Hu T, Zhang Y, Zhang L, Zhang J, Cui D, Li L, Wang J, Wu Q
International journal of molecular sciences 2023 Apr 14;24(8)

Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.

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Chemico-biological interactions 2023 Apr 1;374:110386

Didymin Ameliorates Liver Fibrosis by Alleviating Endoplasmic Reticulum Stress and Glycerophospholipid Metabolism: Based on Transcriptomics and Metabolomics.

Li Y, Li C, Xiong Y, Fang B, Lin X, Huang Q
Drug design, development and therapy 2022;16:1713-1729

C9orf72 regulates the unfolded protein response and stress granule formation by interacting with eIF2α.

Zheng W, Wang K, Wu Y, Yan G, Zhang C, Li Z, Wang L, Chen S
Theranostics 2022;12(17):7289-7306

Inducement of ER Stress by PAD Inhibitor BB-Cl-Amidine to Effectively Kill AML Cells.

Sun YN, Ma YN, Jia XQ, Yao Q, Chen JP, Li H
Current medical science 2022 Oct;42(5):958-965

Peste des Petits Ruminants Virus Upregulates STING to Activate ATF6-Mediated Autophagy.

Zhang R, Lin H, You Q, Zhang Z, Bai L, Chen F, Zhu X, Zhang Z, Li Y
Journal of virology 2022 Oct 26;96(20):e0137522

Jatrorrhizine Improves Endothelial Function in Diabetes and Obesity through Suppression of Endoplasmic Reticulum Stress.

Zhou Y, Wang Y, Vong CT, Zhu Y, Xu B, Ruan CC, Wang Y, Cheang WS
International journal of molecular sciences 2022 Oct 11;23(20)

Hydrogen Sulfide Regulates SERCA2a Ubiquitylation via Muscle RING Finger-1 S-Sulfhydration to Affect Cardiac Contractility in db/db Mice.

Peng S, Zhao D, Li Q, Wang M, Zhang S, Pang K, Huang J, Lu F, Chen H, Zhang W
Cells 2022 Nov 2;11(21)

Dihydroartemisinin alleviates steatosis and inflammation in nonalcoholic steatohepatitis by decreasing endoplasmic reticulum stress and oxidative stress.

Li T, Chen Y, Tan P, Shi H, Huang Z, Cai T, Cheng Y, Du Y, Fu W
Bioorganic chemistry 2022 May;122:105737

Attenuation of Activated eIF2α Signaling by ISRIB Treatment After Spinal Cord Injury Improves Locomotor Function.

Chang L, Liu X, Chen J, Liu H, Wang G, Wang G, Liao X, Shen X
Journal of molecular neuroscience : MN 2022 Mar;72(3):585-597

Benzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stress.

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Biomolecules 2022 Jan 21;12(2)

Isovitexin protects against acute liver injury by targeting PTEN, PI3K and BiP via modification of m6A.

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European journal of pharmacology 2022 Feb 15;917:174749

African Swine Fever Virus K205R Induces ER Stress and Consequently Activates Autophagy and the NF-κB Signaling Pathway.

Wang Q, Zhou L, Wang J, Su D, Li D, Du Y, Yang G, Zhang G, Chu B
Viruses 2022 Feb 15;14(2)

c-Myc plays a critical role in the antileukemic activity of the Mcl-1-selective inhibitor AZD5991 in acute myeloid leukemia.

Liu S, Qiao X, Wu S, Gai Y, Su Y, Edwards H, Wang Y, Lin H, Taub JW, Wang G, Ge Y
Apoptosis : an international journal on programmed cell death 2022 Dec;27(11-12):913-928

African Swine Fever Virus MGF110-7L Induces Host Cell Translation Suppression and Stress Granule Formation by Activating the PERK/PKR-eIF2α Pathway.

Zhong H, Fan S, Du Y, Zhang Y, Zhang A, Jiang D, Han S, Wan B, Zhang G
Microbiology spectrum 2022 Dec 21;10(6):e0328222

Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma.

Xu Z, Xu J, Sun S, Lin W, Li Y, Lu Q, Li F, Yang Z, Lu Y, Liu W
Redox biology 2022 Aug;54:102351

Inhibition of USP14 influences alphaherpesvirus proliferation by degrading viral VP16 protein via ER stress-triggered selective autophagy.

Ming SL, Zhang S, Wang Q, Zeng L, Zhou LY, Wang MD, Ma YX, Han LQ, Zhong K, Zhu HS, Bai YL, Yang GY, Wang J, Chu BB
Autophagy 2022 Aug;18(8):1801-1821

STING1 is essential for an RNA-virus triggered autophagy.

Zhang R, Qin X, Yang Y, Zhu X, Zhao S, Zhang Z, Su Q, Zhao Z, Yin X, Meng X, Zhang Z, Li Y
Autophagy 2022 Apr;18(4):816-828

Inhibition of eIF2α Phosphorylation by Peste des Petits Ruminant Virus Phosphoprotein Facilitates Viral Replication.

Alfred N, Qian B, Qin X, Yin X, Prajapati M, Dou Y, Li Y, Zhang Z
Frontiers in veterinary science 2021;8:645571

The Dietary Supplement γ-Oryzanol Attenuates Hepatic Ischemia Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress and HMGB1/NLRP3 Inflammasome.

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EETs/sEHi alleviates nociception by blocking the crosslink between endoplasmic reticulum stress and neuroinflammation in a central poststroke pain model.

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Journal of neuroinflammation 2021 Sep 16;18(1):211

Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S-sulfhydration.

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Journal of cellular and molecular medicine 2021 Oct;25(19):9154-9167

Endoplasmic reticulum stress manipulates autophagic response that antagonizes polybrominated diphenyl ethers quinone induced cytotoxicity in microglial BV2 cells.

Zhu Q, Liu Z, Wang Y, Song E, Song Y
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Citrus alkaline extracts prevent endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway.

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Phytomedicine : international journal of phytotherapy and phytopharmacology 2021 Aug;89:153599

The Effects of Puerarin on Autophagy Through Regulating of the PERK/eIF2α/ATF4 Signaling Pathway Influences Renal Function in Diabetic Nephropathy.

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Reactive oxygen species mediate anlotinib-induced apoptosis via activation of endoplasmic reticulum stress in pancreatic cancer.

Yang L, Zhou X, Sun J, Lei Q, Wang Q, Pan D, Ding M, Ding Y
Cell death & disease 2020 Sep 17;11(9):766

ROS-mediated PERK-eIF2α-ATF4 pathway plays an important role in arsenite-induced L-02 cells apoptosis via regulating CHOP-DR5 signaling.

Liu C, Zhang A
Environmental toxicology 2020 Oct;35(10):1100-1113

Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.

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Minocycline induces apoptosis of photoreceptor cells by regulating ER stress.

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Exogenous hydrogen sulfide inhibits apoptosis by regulating endoplasmic reticulum stress-autophagy axis and improves myocardial reconstruction after acute myocardial infarction.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human stomach tissue were subjected to SDS PAGE followed by western blot with 11170-1-AP(EIF2S1 antibody) at dilution of 1:500
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using EIF2S1 antibody 11170-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 11170-1-AP(EIF2S1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue