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Protein structure
EIF2S1
Eukaryotic translation initiation factor 2 subunit alphaEIF-2alpha, EIF2, EIF2A
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]). [supplied by OMIM, Feb 2010]
Top validated antibodies |
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| Invitrogen Antibodies |  AHO0802 |
20 references | Monoclonal |
WB
ICC
IP
IHC
FC
OA
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| Proteintech Group | 11170-1-AP |
Polyclonal |
WB
EL
ICC
IP
IHC
FC
|
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| antibodies-online | ABIN393738 |
5 references | Monoclonal |
WB
EL
ICC
IHC
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| Novus Biologicals | H00001965-M01 |
1 references | Monoclonal |
WB
EL
ICC
BN
|
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| NovoPro Bioscience Inc. | 110187 |
Polyclonal |
WB
EL
ICC
IP
IHC
FC
|
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