EIF2S1

The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]). [supplied by OMIM, Feb 2010]

Description

eukaryotic translation initiation factor 2 subunit alpha

Protein family

Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

14:q23.3 (67359997 - 67386516)

Ensembl ID

ENSG00000134001  (ver. 84.38)

Orthologs

Mouse Eif2s1: ENSMUSG00000021116

UniProt

P05198

neXtProt

NX_P05198

Human splice variants
Mouse splice variants