BS8291

antibody from Bioworld Technology, Inc
Targeting: GNLY D2S69E, LAG-2, LAG2, NKG5, TLA519
Provider product page for BS8291
Western blot
Immunohistochemistry

Antibody data

Product number
BS8291 - Provider product page
Provider
Bioworld Technology, Inc
Product name
GNLY polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human GNLY.
Description
Granulysin (NKG5) is a saposin-like protein (SAPLIP) that is expressed in granular cells and functions as an effector molecule for antimicrobial responses in the hematopoietic system. Upon antigen stimulation generated from intracellular pathogens such as bacteria, fungi, and parasites, granulysin mediates the release of cytotoxic granules from Cytolytic T lymphocytes (CTLs) and Natural killer cells (NKs), a process that can lead to apoptosis. The potent antimicrobial activity of granulysin may occur through elevated pathogen host-cell permeability and lysis. Human granulysin is expressed as proteins of two sizes derived from three unique transcripts. Granulysin expressing CTLs, in the presence of perforin, can kill extracellular and intracellular Mycobacterium tuberculosis through a granule-dependent mechanism, suggesting that granulysin may play a broad role in T cell mediated host protection against certain pathogens.
Reactivity
Human
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
GNLY protein structure - BS8291 shown in red.