RTN4IP1

This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Description

Reticulon 4 interacting protein 1

Tissue specificity

Low tissue specificity

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (106570771 - 106629498)

Ensembl ID

ENSG00000130347  (ver. 103.38)

Orthologs

Mouse Rtn4ip1: ENSMUSG00000019864

UniProt

Q8WWV3

neXtProt

NX_Q8WWV3

Human splice variants
Mouse splice variants

Protein structure