66422-1-Ig

antibody from Proteintech Group

Targeting: P4HB DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PO4DB, PO4HB, PROHB

Provider product page for 66422-1-Ig

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Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [25]
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Product number: 66422-1-Ig - Provider product page
Provider: Proteintech Group
Product name: PDI antibody
Antibody type: Monoclonal
Description: PDI antibody (Cat. #66422-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, pig, mouse, rat and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat, Porcine
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 2E6A11
Vial size: 20ul, 150ul

P4HB protein structure - 66422-1-Ig shown in red.

Submitted references Precise subcellular organelle-targeted analyses of hepatotoxicity of Polygonum multiflorum.

Li Y, Duan S, Zhang Y, Liu R, Sun R, Wu J, Ma Z, Li X
Chinese herbal medicines 2026 Jan;18(1):153-166

NDRG2 regulates milkfatbiosynthesis by targeting the AMPK/SREBP1 axis in bovine mammary epithelial cells.

Cheng J, Wang L, Li L, Kuang T, Su H, Ren K, Pan S
International journal of biological macromolecules 2025 Sep;321(Pt 4):146448

Cholesterol biosynthesis induced by radiotherapy inhibits cGAS-STING activation and contributes to colorectal cancer treatment resistance.

Zhu L, Tang Z, Jiang W, Dong Y, Li X, Huang K, Wu T, Xu L, Guo W, Gu Y
Experimental & molecular medicine 2025 May;57(5):1089-1105

Paeoniflorin alleviated STZ-induced diabetic retinopathy via regulation of the PDI/ADAM17/MerTK pathway.

Qi X, Guo H, Xia X, Liu Y, Qiu S, Lin T, He W, Jin L, Cheng J, Hao L, Liu W, Hu H
International immunopharmacology 2025 May 16;155:114571

SARS-CoV-2 nsp16 is regulated by host E3 ubiquitin ligases, UBR5 and MARCHF7.

Tian L, Zhao Z, Gao W, Liu Z, Li X, Zhang W, Li Z
eLife 2025 May 13;13

IRE1α RNase activity is critical for early embryo development by degrading maternal transcripts.

Li C, Tan YP, Gao D, Su R, Xu K, Liu SC, Li XF, Lu YH, Yi LT, Wang G, Ou XH, Meng TG, Sun QY
Nucleic acids research 2025 Jun 6;53(11)

Tetraspanin7 in adipose tissue remodeling and its impact on metabolic health.

Nemoto S, Uchida K, Kubota T, Nakayama M, Han YW, Koyasu S, Ohno H
Molecular metabolism 2025 Jul;97:102168

Liquid-liquid phase separation is essential for reovirus viroplasm formation and immune evasion.

He L, Wang Q, Wang X, Zhou F, Yang C, Li Y, Liao L, Zhu Z, Ke F, Wang Y
Journal of virology 2024 Sep 17;98(9):e0102824

Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1.

Hirano J, Hayashi T, Kitamura K, Nishimura Y, Shimizu H, Okamoto T, Okada K, Uemura K, Yeh MT, Ono C, Taguwa S, Muramatsu M, Matsuura Y
Journal of virology 2024 Jul 23;98(7):e0081324

Acylated Ghrelin Activates PI3K/mTOR Signaling Pathway by Promoting ThPOK Acetylation to Promote Milk Fat Synthesis in Bovine Mammary Epithelial Cells.

Wang J, Cao Y, Long X, Li F, Jiang N, Sun M, Xie Y, Ge Y, Guo W, Liu J, Fu S
Journal of agricultural and food chemistry 2024 Jan 10;72(1):390-404

Pentapeptide PYRAE triggers ER stress-mediated apoptosis of breast cancer cells in mice by targeting RHBDF1-BiP interaction.

Ryu S, Long H, Zheng XL, Song YY, Wang Y, Zhou YJ, Quan XJ, Li LY, Zhang ZS
Acta pharmacologica Sinica 2024 Feb;45(2):378-390

Insulin-Like Growth Factor-Binding Protein 5 Promotes the Cell Proliferation and Osteogenic Potential of Dental Pulp Stem Cells Dependent on Its Nuclear Localisation Sequence.

Sun Z, Li J, Liu H, Fan Z
Journal of oral rehabilitation 2024 Dec;51(12):2664-2674

Aloe Emodin Alleviates Radiation-Induced Heart Disease via Blocking P4HB Lactylation and Mitigating Kynurenine Metabolic Disruption.

Ouyang F, Li Y, Wang H, Liu X, Tan X, Xie G, Zeng J, Zeng G, Luo Q, Zhou H, Chen S, Hou K, Fang J, Zhang X, Zhou L, Li Y, Gao A
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Dec;11(47):e2406026

Periostin Protects Against Alcohol-related Liver Disease by Activating Autophagy by Interacting With Protein Disulfide Isomerase.

Zhang Y, Jin J, Wu H, Huang J, Ye S, Qiu J, Ouyang G, Wu T, Liu F, Liu Y
Cellular and molecular gastroenterology and hepatology 2023;15(6):1475-1504

Identification and characterization of a new variation in DPM2 gene in two Chinese siblings with mild intellectual impairment.

Zhao P, Hu Y, Hu J, Li C, Huang Y, Zhang L, Luo S, Zhu H, Jiang J, He X
Frontiers in genetics 2023;14:930692

SLC35A2 deficiency reduces protein levels of core 1 β-1,3-galactosyltransferase 1 (C1GalT1) and its chaperone Cosmc and affects their subcellular localization.

Wiertelak W, Chabowska K, Szulc B, Zadorozhna Y, Olczak M, Maszczak-Seneczko D
Biochimica et biophysica acta. Molecular cell research 2023 Jun;1870(5):119462

Dickkopf-1 promotes vascular smooth muscle cell foam cell formation and atherosclerosis development through CYP4A11/SREBP2/ABCA1.

Li X, Zheng T, Zhang Y, Zhao Y, Liu F, Dai S, Liu X, Zhang M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23048

CIDEA Regulates De Novo Fatty Acid Synthesis in Bovine Mammary Epithelial Cells by Targeting the AMPK/PPARγ Axis and Regulating SREBP1.

Cheng J, Xu D, Chen L, Guo W, Hu G, Liu J, Fu S
Journal of agricultural and food chemistry 2022 Sep 14;70(36):11324-11335

Sigma‑1 receptor overexpression promotes proliferation and ameliorates cell apoptosis in β‑cells.

Ke M, Lin F, Wang H, He G, Feng J, Song L, Xu Y, Liu J
Molecular medicine reports 2022 May;25(5)

A Splice Switch in SIGIRR Causes a Defect of IL-37-Dependent Anti-Inflammatory Activity in Cystic Fibrosis Airway Epithelial Cells.

Ueno-Shuto K, Kamei S, Hayashi M, Fukuyama A, Uchida Y, Tokutomi N, Suico MA, Kai H, Shuto T
International journal of molecular sciences 2022 Jul 13;23(14)

Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERα levels.

Huang T, Wu Q, Huang H, Zhang C, Wang L, Wang L, Liu Y, Li W, Zhang J, Liu Y
Biochimica et biophysica acta. General subjects 2022 Jan;1866(1):130046

A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function.

McCaughey J, Stevenson NL, Mantell JM, Neal CR, Paterson A, Heesom K, Stephens DJ
Journal of cell science 2021 Sep 1;134(17)

Highly Efficient Method for Intracellular Delivery of Proteins Mediated by Cholera Toxin-Induced Protein Internalization.

Jia X, Zhang Y, Wang T, Fu Y
Molecular pharmaceutics 2021 Nov 1;18(11):4067-4078

A cross-talk between epithelium and endothelium mediates human alveolar-capillary injury during SARS-CoV-2 infection.

Wang P, Luo R, Zhang M, Wang Y, Song T, Tao T, Li Z, Jin L, Zheng H, Chen W, Zhao M, Zheng Y, Qin J
Cell death & disease 2020 Dec 8;11(12):1042

HRD1-mediated PTEN degradation promotes cell proliferation and hepatocellular carcinoma progression.

Liu L, Long H, Wu Y, Li H, Dong L, Zhong JL, Liu Z, Yang X, Dai X, Shi L, Ren M, Lin Z
Cellular signalling 2018 Oct;50:90-99

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