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Protein structure
P4HB
Prolyl 4-hydroxylase subunit betaDSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PO4DB, PO4HB, PROHB
This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  11245-1-AP |
55 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC
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| Invitrogen Antibodies | MA3-019 |
92 references | Monoclonal |
WB
ICC
IP
IHC
FC
IEM
OA
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| Boster Biological Technology | A02335-1 |
3 references | Polyclonal |
WB
EL
ICC
IHC
FC
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| GeneTex | GTX101468 |
4 references | Polyclonal |
WB
ICC
IHC
IEM
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| LSBio | LS-C818204 |
Polyclonal |
WB
EL
ICC
IP
IHC
|
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