CACNA1B

The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Description

calcium voltage-gated channel subunit alpha1 B

Protein family

Disease related genes, FDA approved drug targets, Mapped to neXtProt, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted membrane proteins, Protein evidence (Peptideatlas), Voltage-gated ion channels

Chromosome

9:q34.3 (137877782 - 138124624)

Ensembl ID

ENSG00000148408  (ver. 98.38)

Orthologs

Mouse Cacna1b: ENSMUSG00000004113

UniProt

Q00975

neXtProt

NX_Q00975

Human splice variants
Mouse splice variants