CACNA1B

The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Description

Calcium voltage-gated channel subunit alpha1 B

Tissue specificity

Tissue enhanced (brain, pituitary gland, testis)

Subcell location

Mitochondria

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Voltage-gated ion channels

Chromosome

9:q34.3 (137877782 - 138124624)

Ensembl ID

ENSG00000148408  (ver. 103.38)

Orthologs

Mouse Cacna1b: ENSMUSG00000004113

UniProt

Q00975

neXtProt

NX_Q00975

Human splice variants
Mouse splice variants