KCNJ4

Several different potassium channels are known to be involved with electrical signaling in the nervous system. One class is activated by depolarization whereas a second class is not. The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into the cell rather than out of it. This asymmetry in potassium ion conductance plays a key role in the excitability of muscle cells and neurons. The protein encoded by this gene is an integral membrane protein and member of the inward rectifier potassium channel family. The encoded protein has a small unitary conductance compared to other members of this protein family. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Potassium inwardly rectifying channel subfamily J member 4

Tissue specificity

Group enriched (brain, heart muscle)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

22 (38426327 - 38455199)

Ensembl ID

ENSG00000168135  (ver. 103.38)

Orthologs

Mouse Kcnj4: ENSMUSG00000044216

UniProt

P48050

neXtProt

NX_P48050

Human splice variants
Mouse splice variants

Protein structure