14719-1-AP

antibody from Proteintech Group

Targeting: PHGDH PDG, PGDH, SERA

Provider product page for 14719-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [93]
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Validations
Western blot [1]
Immunohistochemistry [1]

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Product number: 14719-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#14719-1-AP, RRID:AB_2283938
Product name: PHGDH antibody
Antibody type: Polyclonal
Description: KD/KO validated PHGDH antibody (Cat. #14719-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PHGDH protein structure - 14719-1-AP shown in red.

Submitted references Andrographolide blocked the progression of endometriosis by promoting ferroptosis via inhibiting anabolism of serine.

Ye W, Zhang N, Li J, Wang F, Liu X, Zhang R, Chen H, Cheng L, Wei Z, Zhu F
Naunyn-Schmiedeberg's archives of pharmacology 2026 Mar;399(6):7935-7952

Dextrorotatory kynurenine suppresses acute rejection through inhibiting M1 macrophage-mediated inflammation.

Zhao Y, Wu J, Li Y, Cao Y, Zhu T, Guo Y, Yang C, Zhu D
EMBO molecular medicine 2026 Mar;18(3):979-1008

ASCC3 promotes chemosensitivity in colorectal cancer cells.

Tu A, Martyn RDC, Cui S, Batenburg NL, Fayyazi R, Di Pastena F, Berthiaume L, Singh K, Saleem R, Scott GR, Berg T, Audet-Walsh É, Steinberg GR, Zhu XD
Scientific reports 2026 Mar 17;16(1)

Targeting serine synthesis pathway to reverse paclitaxel resistance in NSCLC with combination of paclitaxel and anlotinib.

Yu M, Hong Y, Pan Q, Zheng P, He Y, Zhu W, Xu S, Lv Q
Journal of experimental & clinical cancer research : CR 2026 Jan 5;45(1):30

PHGDH knockdown activates autophagic flux to suppress migration and invasion of gastric cancer cells.

Li S, Cao Y, Xu W, Wang X, Li R, Huang J, Zhang H
Translational cancer research 2026 Jan 31;15(1):23

A Highly Efficient siRNA Transfection Method in Primary Cultured Cortical Neurons.

Wang X, Li Y, Sun X, Cui Y, Zhang Z
Bio-protocol 2026 Jan 20;16(2):e5567

PHGDH-dependent serine metabolism in astrocytes: A key regulator of oxidative stress and pyroptosis in cerebral ischemia-reperfusion injury.

Zhang J, Luo Y, Xie C, Zhang M, Qin H, Zhou Y, Wu X, Hu C, Hu F, Fei X, Zhang H, Li J, Fu Y, Yuan Y, Yang S, Gao D
Redox biology 2026 Feb;89:103954

Tumor metabolic adaptation induced by L-asparaginase reveals a vulnerability to PARP1/2 inhibitor in B-cell lymphomas.

Aussel A, Nemazanyy I, Vandenberghe A, Meola P, Dorat N, Paul R, Habbouche L, Exposito L, Nottet N, Petrilli V, Chiche E, Mounier N, Marchetti S, Chaveroux C, Ricci JE, Chiche J
Nature communications 2026 Feb 27;17(1)

Phosphoglycerate dehydrogenase-mediated serine reprogramming aggravates macrophage hyperinflammation in murine Pseudomonas aeruginosa pneumonia.

Chen R, Zeng R, Shi M, Zhang G, Wang F, Yang Q, Jiang Y, Zhang Y, Li Y, Qu J
Nature communications 2026 Feb 20;17(1)

ΔNp63α drives serine synthesis to promote carboplatin resistance in NSCLC.

Deng L, Yang X, Zhang J, Zhou X, Ma R, Wu Z, Chen H
Cell death & disease 2026 Feb 17;17(1):227

The role of glutamine/Nrf2-enhanced PHGDH in Cadmium-induced lactate utilization.

Pang Y, Li S, Zhang Q, Liu Y, Kong Y, Cao J
Free radical biology & medicine 2026 Feb 16;244:296-311

PHGDH Orchestrates Cell Cycle Progression to Drive Cardiomyocyte Proliferation and Myocardial Regeneration via TGF-β/Smad Signalling Pathway.

Zhang H, Zhang L, Feng Z, Li X, Qiu Z, Wang X, Qian L
Cell proliferation 2026 Apr;59(4):e70123

Genome-wide mapping of RNA-protein associations through sequencing.

Qi Z, Xue S, Chen J, Zhao W, Johnson K, Wen X, Charles Richard JL, Lin P, Zhong S
Nature biotechnology 2025 Sep 9;

HMGA2/PHGDH axis-mediated glycolysis under hypoxia is required for cadmium-induced A549 cell migration.

Gao C, Xie Q, Li L, Luo S, Fan J, Cao J
Ecotoxicology and environmental safety 2025 Sep 15;303:118787

Impaired xCT-mediated cystine uptake drives serine and proline metabolic reprogramming and mitochondrial fission in skeletal muscle cells.

Kanaan MN, Karam CY, Kennedy LS, Pileggi CA, Hamilton L, Cuperlovic-Culf M, Harper ME
Redox biology 2025 Oct;86:103839

Pharmacological inhibition of PSPH reduces serine levels and epileptic seizures.

Sha L, Wang Y, Meng P, Deng Y, Chen T, Zhang X, Ye Y, Xu Q
Nature chemical biology 2025 Nov;21(11):1742-1753

m(6)A/IGF2BP3-driven serine biosynthesis fuels AML stemness and metabolic vulnerability.

Huang F, Wang Y, Zhang X, Gao W, Li J, Yang Y, Mo H, Prince E, Long Y, Hu J, Jiang C, Kang Y, Chen Z, Hu YC, Zeng C, Yang L, Chen CW, Chen J, Huang H, Weng H
Nature communications 2025 May 6;16(1):4214

De novo serine biosynthesis is protective in mitochondrial disease.

Jackson CB, Marmyleva A, Monteuuis G, Awadhpersad R, Mito T, Zamboni N, Tatsuta T, Vincent AE, Wang L, Khan NA, Langer T, Carroll CJ, Suomalainen A
Cell reports 2025 May 27;44(5):115710

De Novo Serine Synthesis Is a Metabolic Vulnerability That Can Be Exploited to Overcome Sunitinib Resistance in Advanced Renal Cell Carcinoma.

Teisseire M, Sahu U, Parola J, Tsai MC, Vial V, Durivault J, Grépin R, Cormerais Y, Molina C, Gouraud A, Pagès G, Ben-Sahra I, Giuliano S
Cancer research 2025 May 15;85(10):1857-1873

Chemotherapy-induced macrophage CXCL7 expression drives tumor chemoresistance via the STAT1/PHGDH-serine metabolism axis and SAM paracrine feedback to M2 polarization.

Liu S, Gong H, Li P, Hu J, Li Y, Xu R, Cai J, Wang S, Cai J, Ma H, Mi X, Li Y, Zhou Q, Zhou Q, Yang W, Li R, Song L, Fang L
Cell death & disease 2025 May 14;16(1):379

An in vivo screen identifies NAT10 as a master regulator of brain metastasis.

Chen JF, Xu P, Cai WL, Chen H, Wingrove E, Shi X, Li W, Biancon G, Zhang M, Balabaki A, Krop ED, Asare E, Zhang Y, Yin M, Tebaldi T, Meier JL, Westbrook TF, Halene S, Liu Y, Shen H, Nguyen DX, Yan Q
Science advances 2025 Mar 28;11(13):eads6021

PHGDH activation fuels glioblastoma progression and radioresistance via serine synthesis pathway.

Liu X, Liu B, Wang J, Liu H, Wu J, Qi Y, Liu Y, Zhu H, Li C, Yang L, Song J, Yao G, Tian W, Zhao K, Han L, Shu K, Zhang S, Man J, You C, Huang H, Li R
Journal of experimental & clinical cancer research : CR 2025 Mar 19;44(1):99

Integrative multi-omics reveals the mechanism of ulcerative colitis treated with Ma-Mu-Ran antidiarrheal capsules.

Huang H, Duan B, Huang Z, Wang S, Wen Y, Jiang Q, Chen P, Huang P, Liu J, Zheng S, Ye Y, Zhang D, Wang Q, Huang F, Li J, Han L
Rapid communications in mass spectrometry : RCM 2025 Mar 15;39(5):e9939

ZNF146 accelerates lung adenocarcinoma progression through MDM2/p53 and PHGDH/ferroptosis.

Zhu J, Ren S, Yi Y, Wu Z, Lin H, Shan G, Huang X, Pan B, Hu Z, Sui Q, Zhan C, Wang S, Liang J
Cell & bioscience 2025 Jun 28;15(1):94

Transcriptional regulation by PHGDH drives amyloid pathology in Alzheimer's disease.

Chen J, Hadi F, Wen X, Zhao W, Xu M, Xue S, Lin P, Calandrelli R, Richard JLC, Song Z, Li J, Amani A, Liu Y, Chen X, Zhong S
Cell 2025 Jun 26;188(13):3513-3529.e26

VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells.

Roy G, Ordóñez A, Binns DD, Rodrigues-Dos-Santos K, Kwakye MB, King GC, Kuntz RL, Mukherjee N, Templin AT, Tan Z, Richardson TI, Doud EH, Mosley AL, Schueler KL, Emfinger CH, Attie AD, Keller MP, Johnson TS, Kalwat MA
Cell reports 2025 Jun 24;44(6):115834

Ethyl Acetate Fraction of Zanthoxylum bungeanum Ameliorates Cognitive Deficit by Facilitating the PHGDH-Dependent Astrocyte-Neuron Serine Shuttle in Aging Mice.

Zhao M, Zeng L, Zhou Y, Yang C, Sheng R, Liu X, Wen W, Yang S, Zhang S, Xu S
Journal of agricultural and food chemistry 2025 Jul 2;73(26):16301-16316

Integrative metabolome and transcriptome analyses provide insights into PHGDH in colon cancer organoids.

Chen L, Dai Z, Zhang Y, Sheng H, Hu B, Du J, Chang J, Xu W, Hu Y
Bioscience reports 2025 Jan 28;45(1):1-12

Gut bacterial L-lysine alters metabolism and histone methylation to drive dendritic cell tolerance.

Tang Q, Fan G, Peng X, Sun X, Kong X, Zhang L, Zhang C, Liu Y, Yang J, Yu K, Miao C, Yao Z, Li L, Zhang ZS, Wang Q
Cell reports 2025 Jan 28;44(1):115125

MYC-dependent upregulation of the de novo serine and glycine synthesis pathway is a targetable metabolic vulnerability in group 3 medulloblastoma.

Adiamah M, Poole B, Lindsey JC, Kohe S, Morcavallo A, Burté F, Hill RM, Blair H, Thompson D, Singh M, Swartz S, Crosier S, Zhang T, Maddocks ODK, Peet A, Chesler L, Hickson I, Maxwell RJ, Clifford SC
Neuro-oncology 2025 Jan 12;27(1):237-253

MAPK13 phosphorylates PHGDH and promotes its degradation via chaperone-mediated autophagy during liver injury.

Xing R, Liu R, Man Y, Liu C, Zhang Y, Gao H, Yang W
Cell discovery 2025 Feb 18;11(1):15

Integrated computational and experimental approach to identify Nrf2-regulated molecular targets in cerebral ischemia.

Lewczuk A, Boratyńska-Jasińska A, Charzewski Ł, Beręsewicz-Haller M, Zabłocka B
Pharmacological reports : PR 2025 Dec;77(6):1639-1656

Unfolded protein response kinase PERK supports survival and metastasis of circulating tumor cell clusters via SAM synthesis and H3K4me3-dependent PDGFB signaling.

Tang R, Sun Y, Deng A, Liu J, Dai P, Chen J, Deng C, Liu H, Hai Y, Tong Y, Du YE, Liu M, Luo H
Cancer communications (London, England) 2025 Dec;45(12):1706-1733

Activation of the De Novo Serine Synthesis Pathway and Disruption of Insulin Signaling Induced by Supplemental SeMet in Vitro.

Zhan S, Huang J, Liu Y, Han F, Wang J, Wang Q, Huang Z
Biological trace element research 2025 Aug;203(8):4087-4099

NSUN2 promotes colorectal cancer progression by stabilizing PHGDH mRNA to promote serine metabolism reprogramming.

Li H, Gong T, Zhao Y, Luo Y, Tang S, Wang T, Lin H, Zhong M
Cancer & metabolism 2025 Aug 14;13(1):37

Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage.

Liu Y, Cui F, Xu A, Wang B, Ma Y, Zhang Q, Sun Q, Zheng Y, Xue Y, Sun Y, Bian L
International journal of biological sciences 2024;20(11):4277-4296

PHGDH is Key to a Prognostic Multigene Signature and a Potential Therapeutic Target in Acute Myeloid Leukemia.

Zhong J, Huang K, Xie S, Tan A, Peng J, Nie D, Ma L, Li Y
Journal of Cancer 2024;15(9):2538-2548

Molecular glue triggers degradation of PHGDH by enhancing the interaction between DDB1 and PHGDH.

Huang Z, Zhang K, Jiang Y, Wang M, Li M, Guo Y, Gao R, Li N, Wang C, Chen J, Wang J, Liu N, Liu X, Liu S, Wei M, Yang C, Yang G
Acta pharmaceutica Sinica. B 2024 Sep;14(9):4001-4013

Genome-Wide Mapping of RNA-Protein Associations via Sequencing.

Qi Z, Xue S, Chen J, Zhao W, Johnson K, Wen X, Richard JLC, Zhong S
bioRxiv : the preprint server for biology 2024 Sep 4;

Compensatory activity of the PC-ME1 metabolic axis underlies differential sensitivity to mitochondrial complex I inhibition.

Del Prado L, Jaraíz-Rodríguez M, Agro M, Zamora-Dorta M, Azpiazu N, Calleja M, Lopez-Manzaneda M, de Juan-Sanz J, Fernández-Rodrigo A, Esteban JA, Girona M, Quintana A, Balsa E
Nature communications 2024 Oct 7;15(1):8682

Preclinical efficacy of CBR-5884 against epithelial ovarian cancer cells by targeting the serine synthesis pathway.

Gong K, Huang Y, Zheng Y, Zhu Y, Hao W, Shi K
Discover oncology 2024 May 11;15(1):154

Serine deficiency exacerbates psoriatic skin inflammation by regulating S-adenosyl methionine-dependent DNA methylation and NF-κB signalling activation in keratinocytes.

Meng Q, Liu Y, Yao L, Ma Z, Guo L, Hu T, Luo Y, Chen J, Dang E, Li Z
Journal of the European Academy of Dermatology and Venereology : JEADV 2024 Jan;38(1):145-156

Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.

Wang C, Chen Q, Chen S, Fan L, Gan Z, Zhao M, Shi L, Bin P, Yang G, Zhou X, Ren W
Molecular cell 2024 Feb 15;84(4):744-759.e6

ATF4/PHGDH mediates the effects of ER stress on cadmium-induced autophagy and glycolysis.

Yang Y, Li S, Yang Y, Li Q, Liu Y, Cao J
Toxicology 2024 Dec;509:153976

Non-canonical function of PHGDH promotes HCC metastasis by interacting with METTL3.

Cheng B, Ma J, Tang N, Liu R, Peng P, Wang K
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2427-2438

Aberrant regulation of serine metabolism drives extracellular vesicle release and cancer progression.

Yamamoto T, Nakayama J, Urabe F, Ito K, Nishida-Aoki N, Kitagawa M, Yokoi A, Kuroda M, Hattori Y, Yamamoto Y, Ochiya T
Cell reports 2024 Aug 27;43(8):114517

PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.

Yamamoto T, Hayashida T, Masugi Y, Oshikawa K, Hayakawa N, Itoh M, Nishime C, Suzuki M, Nagayama A, Kawai Y, Hishiki T, Matsuura T, Naito Y, Kubo A, Yamamoto A, Yoshioka Y, Kurahori T, Nagasaka M, Takizawa M, Takano N, Kawakami K, Sakamoto M, Wakui M, Yamamoto T, Kitagawa Y, Kabe Y, Horisawa K, Suzuki A, Matsumoto M, Suematsu M
Cancer research 2024 Apr 1;84(7):1065-1083

ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.

Wang H, Lin F, Xu Z, Yu S, Li G, Liao S, Zhao W, Zhang F, Wang J, Wang S, Ouyang C, Zhang C, Xia H, Wu Y, Jiang B, Li Q
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556

eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation.

Zhang Y, Wan X, Yang X, Liu X, Huang Q, Zhou L, Zhang S, Liu S, Xiong Q, Wei M, Qiu L, Zhang B, Han J
The Journal of biological chemistry 2023 Sep;299(9):105177

Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma.

Hsieh CH, Huang CT, Cheng YS, Hsu CH, Hsu WM, Chung YH, Liu YL, Yang TS, Chien CY, Lee YH, Huang HC, Juan HF
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115429

Single-cell transcriptome analyses reveal critical roles of RNA splicing during leukemia progression.

Wu B, Chen X, Pan X, Deng X, Li S, Wang Z, Wang J, Liao D, Xu J, Chen M, Zhao C, Xue Z, Wang Y, Niu T, Lin J, Chen L, Liu Y, Chen C
PLoS biology 2023 May;21(5):e3002088

Newcastle Disease Virus Manipulates Mitochondrial MTHFD2-Mediated Nucleotide Metabolism for Virus Replication.

Tang N, Chen P, Zhao C, Liu P, Tan L, Song C, Qiu X, Liao Y, Liu X, Luo T, Sun Y, Ding C
Journal of virology 2023 Mar 30;97(3):e0001623

Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.

Wu Y, Tang L, Huang H, Yu Q, Hu B, Wang G, Ge F, Yin T, Li S, Yu X
Nature communications 2023 Mar 10;14(1):1323

Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer.

Fan TW, Winnike J, Al-Attar A, Belshoff AC, Lorkiewicz PK, Tan JL, Wu M, Higashi RM, Lane AN
Metabolites 2023 Jun 21;13(7)

Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.

Zhai L, Yang X, Cheng Y, Wang J
Cancer medicine 2023 Aug;12(15):16337-16358

PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.

Zhang X, Sun M, Jiao Y, Lin B, Yang Q
Oxidative medicine and cellular longevity 2022;2022:9029544

Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway.

Zhang Y, Gong R, Liu Y, Sun X, Liang J, Zhou Y, Wang Y, Yu W, Wang Y, Tang L, He A, Shen Z, Yao Y, Hu H, Liu X, Zhang J
Frontiers in oncology 2022;12:842406

ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.

Li S, Yang H, Li W, Liu JY, Ren LW, Yang YH, Ge BB, Zhang YZ, Fu WQ, Zheng XJ, Du GH, Wang JH
Acta pharmacologica Sinica 2022 Oct;43(10):2709-2722

Quantitative proteomics identified circulating biomarkers in lung adenocarcinoma diagnosis.

Chen H, Lai X, Zhu Y, Huang H, Zeng L, Zhang L
Clinical proteomics 2022 Nov 21;19(1):44

PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.

Chen X, Calandrelli R, Girardini J, Yan Z, Tan Z, Xu X, Hiniker A, Zhong S
Cell metabolism 2022 May 3;34(5):651-653

Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.

Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G
Nature communications 2022 May 16;13(1):2698

PERK is a critical metabolic hub for immunosuppressive function in macrophages.

Raines LN, Zhao H, Wang Y, Chen HY, Gallart-Ayala H, Hsueh PC, Cao W, Koh Y, Alamonte-Loya A, Liu PS, Ivanisevic J, Lio CJ, Ho PC, Huang SC
Nature immunology 2022 Mar;23(3):431-445

Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver.

Chen H, Liu C, Wang Q, Xiong M, Zeng X, Yang D, Xie Y, Su H, Zhang Y, Huang Y, Chen Y, Yue J, Liu C, Wang S, Huang K, Zheng L
Nature communications 2022 Jul 4;13(1):3835

TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine.

Luo X, Ge J, Liu J, Liu Z, Bi C, Lan S
Experimental cell research 2022 Jul 1;416(1):113136

Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.

Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550

The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA.

Feng Z, Li K, Qin K, Liang J, Shi M, Ma Y, Zhao S, Liang H, Han D, Shen B, Peng C, Chen H, Jiang L
Journal of hematology & oncology 2022 Aug 17;15(1):112

Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis.

Sun S, Li C, Cui K, Liu B, Zhou M, Cao Y, Zhang J, Bian Z, Fei B, Huang Z
Frontiers in cell and developmental biology 2021;9:770006

CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.

Liu X, Liu Y, Liu Z, Lin C, Meng F, Xu L, Zhang X, Zhang C, Zhang P, Gong S, Wu N, Ren Z, Song J, Zhang Y
Molecular cancer 2021 Sep 8;20(1):114

Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.

Wang J, Filippakis H, Hougard T, Du H, Ye C, Liu HJ, Zhang L, Hindi K, Bagwe S, Nijmeh J, Asara JM, Shi W, El-Chemaly S, Henske EP, Lam HC
Proceedings of the National Academy of Sciences of the United States of America 2021 Sep 28;118(39)

Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.

Zhang Y, Yu H, Zhang J, Gao H, Wang S, Li S, Wei P, Liang J, Yu G, Wang X, Li X, Li D, Yang W
The Journal of clinical investigation 2021 Nov 1;131(21)

Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.

Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060

Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.

Huang H, Liu K, Ou H, Qian X, Wan J
Molecular medicine reports 2021 Jun;23(6)

Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.

Gheller BJ, Blum JE, Lim EW, Handzlik MK, Hannah Fong EH, Ko AC, Khanna S, Gheller ME, Bender EL, Alexander MS, Stover PJ, Field MS, Cosgrove BD, Metallo CM, Thalacker-Mercer AE
Molecular metabolism 2021 Jan;43:101106

Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16.

Yang RL, Huang HM, Han CS, Cui SJ, Zhou YK, Zhou YH
Journal of dental research 2021 Jan;100(1):90-97

Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors.

Tan Y, Zhou X, Gong Y, Gou K, Luo Y, Jia D, Dai L, Zhao Y, Sun Q
Cellular and molecular life sciences : CMLS 2021 Dec 31;79(1):27

Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis.

Zhang G, Yang Y, Hu H, Liu K, Li B, Zhu Y, Wang Z, Wu Q, Mei Y
Oncogene 2021 Apr;40(16):2936-2951

Phosphoglycerate dehydrogenase promotes proliferation and bortezomib resistance through increasing reduced glutathione synthesis in multiple myeloma.

Wu X, Xia J, Zhang J, Zhu Y, Wu Y, Guo J, Chen S, Lei Q, Meng B, Kuang C, Feng X, He Y, Shen Y, Li X, Qiu L, Li G, Zhou W
British journal of haematology 2020 Jul;190(1):52-66

The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.

Sinha T, Naash MI, Al-Ubaidi MR
iScience 2020 Apr 24;23(4):101004

Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.

Zhang P, Wang Q, Lin Z, Yang P, Dou K, Zhang R
OncoTargets and therapy 2019;12:11751-11763

De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.

Fan TWM, Bruntz RC, Yang Y, Song H, Chernyavskaya Y, Deng P, Zhang Y, Shah PP, Beverly LJ, Qi Z, Mahan AL, Higashi RM, Dang CV, Lane AN
The Journal of biological chemistry 2019 Sep 6;294(36):13464-13477

Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.

Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X, Gao P
Life science alliance 2019 Oct;2(5)

The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.

Xu L, Wang L, Zhou L, Dorfman RG, Pan Y, Tang D, Wang Y, Yin Y, Jiang C, Zou X, Wu J, Zhang M
Neoplasia (New York, N.Y.) 2019 May;21(5):429-441

Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.

Guo J, Gu X, Zheng M, Zhang Y, Chen L, Li H
Bioorganic chemistry 2019 Jun;87:16-22

Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.

Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M, Lin SH, Huang M
Nature communications 2019 Jun 20;10(1):2701

A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.

Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H
FEBS letters 2019 Apr;593(8):763-776

Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.

Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM
American journal of respiratory cell and molecular biology 2018 May;58(5):585-593

Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling.

Coleman V, Sa-Nguanmoo P, Koenig J, Schulz TJ, Grune T, Klaus S, Kipp AP, Ost M
Scientific reports 2018 Feb 5;8(1):2446

Proximal tubule glutamine synthetase expression is necessary for the normal response to dietary protein restriction.

Lee HW, Osis G, Handlogten ME, Verlander JW, Weiner ID
American journal of physiology. Renal physiology 2017 Jul 1;313(1):F116-F125

Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase.

Liu S, Sun Y, Jiang M, Li Y, Tian Y, Xue W, Ding N, Sun Y, Cheng C, Li J, Miao X, Liu X, Zheng L, Huang K
Hepatology (Baltimore, Md.) 2017 Aug;66(2):631-645

Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action.

Ost M, Coleman V, Voigt A, van Schothorst EM, Keipert S, van der Stelt I, Ringel S, Graja A, Ambrosi T, Kipp AP, Jastroch M, Schulz TJ, Keijer J, Klaus S
Molecular metabolism 2016 Feb;5(2):79-90

Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.

Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM
The Journal of biological chemistry 2016 Dec 30;291(53):27239-27251

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Jurkat cells were subjected to SDS PAGE followed by western blot with 14719-1-AP(PHGDH antibody) at dilution of 1:1200
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PHGDH antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PHGDH. This antibody recognizes human,mouse,rat antigen. The PHGDH antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 14719-1-AP.pdf

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