Antibody data
- Antibody Data
- Antigen structure
- References [49]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
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- Product number
- 14719-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#14719-1-AP, RRID:AB_2283938
- Product name
- PHGDH antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PHGDH antibody (Cat. #14719-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references PHGDH is Key to a Prognostic Multigene Signature and a Potential Therapeutic Target in Acute Myeloid Leukemia.
Preclinical efficacy of CBR-5884 against epithelial ovarian cancer cells by targeting the serine synthesis pathway.
Serine deficiency exacerbates psoriatic skin inflammation by regulating S-adenosyl methionine-dependent DNA methylation and NF-κB signalling activation in keratinocytes.
Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation.
Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma.
Single-cell transcriptome analyses reveal critical roles of RNA splicing during leukemia progression.
Newcastle Disease Virus Manipulates Mitochondrial MTHFD2-Mediated Nucleotide Metabolism for Virus Replication.
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.
Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway.
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
Quantitative proteomics identified circulating biomarkers in lung adenocarcinoma diagnosis.
PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.
PERK is a critical metabolic hub for immunosuppressive function in macrophages.
Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver.
TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine.
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA.
Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis.
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.
Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16.
Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors.
Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis.
The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.
Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.
A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling.
Proximal tubule glutamine synthetase expression is necessary for the normal response to dietary protein restriction.
Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase.
Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action.
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.
Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Zhong J, Huang K, Xie S, Tan A, Peng J, Nie D, Ma L, Li Y
Journal of Cancer 2024;15(9):2538-2548
Journal of Cancer 2024;15(9):2538-2548
Preclinical efficacy of CBR-5884 against epithelial ovarian cancer cells by targeting the serine synthesis pathway.
Gong K, Huang Y, Zheng Y, Zhu Y, Hao W, Shi K
Discover oncology 2024 May 11;15(1):154
Discover oncology 2024 May 11;15(1):154
Serine deficiency exacerbates psoriatic skin inflammation by regulating S-adenosyl methionine-dependent DNA methylation and NF-κB signalling activation in keratinocytes.
Meng Q, Liu Y, Yao L, Ma Z, Guo L, Hu T, Luo Y, Chen J, Dang E, Li Z
Journal of the European Academy of Dermatology and Venereology : JEADV 2024 Jan;38(1):145-156
Journal of the European Academy of Dermatology and Venereology : JEADV 2024 Jan;38(1):145-156
Serine synthesis sustains macrophage IL-1β production via NAD(+)-dependent protein acetylation.
Wang C, Chen Q, Chen S, Fan L, Gan Z, Zhao M, Shi L, Bin P, Yang G, Zhou X, Ren W
Molecular cell 2024 Feb 15;84(4):744-759.e6
Molecular cell 2024 Feb 15;84(4):744-759.e6
PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
Yamamoto T, Hayashida T, Masugi Y, Oshikawa K, Hayakawa N, Itoh M, Nishime C, Suzuki M, Nagayama A, Kawai Y, Hishiki T, Matsuura T, Naito Y, Kubo A, Yamamoto A, Yoshioka Y, Kurahori T, Nagasaka M, Takizawa M, Takano N, Kawakami K, Sakamoto M, Wakui M, Yamamoto T, Kitagawa Y, Kabe Y, Horisawa K, Suzuki A, Matsumoto M, Suematsu M
Cancer research 2024 Apr 1;84(7):1065-1083
Cancer research 2024 Apr 1;84(7):1065-1083
ZEB1 Transcriptionally Activates PHGDH to Facilitate Carcinogenesis and Progression of HCC.
Wang H, Lin F, Xu Z, Yu S, Li G, Liao S, Zhao W, Zhang F, Wang J, Wang S, Ouyang C, Zhang C, Xia H, Wu Y, Jiang B, Li Q
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556
Cellular and molecular gastroenterology and hepatology 2023;16(4):541-556
eIF3i promotes colorectal cancer cell survival via augmenting PHGDH translation.
Zhang Y, Wan X, Yang X, Liu X, Huang Q, Zhou L, Zhang S, Liu S, Xiong Q, Wei M, Qiu L, Zhang B, Han J
The Journal of biological chemistry 2023 Sep;299(9):105177
The Journal of biological chemistry 2023 Sep;299(9):105177
Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma.
Hsieh CH, Huang CT, Cheng YS, Hsu CH, Hsu WM, Chung YH, Liu YL, Yang TS, Chien CY, Lee YH, Huang HC, Juan HF
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115429
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Oct;166:115429
Single-cell transcriptome analyses reveal critical roles of RNA splicing during leukemia progression.
Wu B, Chen X, Pan X, Deng X, Li S, Wang Z, Wang J, Liao D, Xu J, Chen M, Zhao C, Xue Z, Wang Y, Niu T, Lin J, Chen L, Liu Y, Chen C
PLoS biology 2023 May;21(5):e3002088
PLoS biology 2023 May;21(5):e3002088
Newcastle Disease Virus Manipulates Mitochondrial MTHFD2-Mediated Nucleotide Metabolism for Virus Replication.
Tang N, Chen P, Zhao C, Liu P, Tan L, Song C, Qiu X, Liao Y, Liu X, Luo T, Sun Y, Ding C
Journal of virology 2023 Mar 30;97(3):e0001623
Journal of virology 2023 Mar 30;97(3):e0001623
Phosphoglycerate dehydrogenase activates PKM2 to phosphorylate histone H3T11 and attenuate cellular senescence.
Wu Y, Tang L, Huang H, Yu Q, Hu B, Wang G, Ge F, Yin T, Li S, Yu X
Nature communications 2023 Mar 10;14(1):1323
Nature communications 2023 Mar 10;14(1):1323
Glutamine and amino acid metabolism as a prognostic signature and therapeutic target in endometrial cancer.
Zhai L, Yang X, Cheng Y, Wang J
Cancer medicine 2023 Aug;12(15):16337-16358
Cancer medicine 2023 Aug;12(15):16337-16358
PHGDH Inhibitor CBR-5884 Inhibits Epithelial Ovarian Cancer Progression via ROS/Wnt/β-Catenin Pathway and Plays a Synergistic Role with PARP Inhibitor Olaparib.
Zhang X, Sun M, Jiao Y, Lin B, Yang Q
Oxidative medicine and cellular longevity 2022;2022:9029544
Oxidative medicine and cellular longevity 2022;2022:9029544
Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway.
Zhang Y, Gong R, Liu Y, Sun X, Liang J, Zhou Y, Wang Y, Yu W, Wang Y, Tang L, He A, Shen Z, Yao Y, Hu H, Liu X, Zhang J
Frontiers in oncology 2022;12:842406
Frontiers in oncology 2022;12:842406
ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway.
Li S, Yang H, Li W, Liu JY, Ren LW, Yang YH, Ge BB, Zhang YZ, Fu WQ, Zheng XJ, Du GH, Wang JH
Acta pharmacologica Sinica 2022 Oct;43(10):2709-2722
Acta pharmacologica Sinica 2022 Oct;43(10):2709-2722
Quantitative proteomics identified circulating biomarkers in lung adenocarcinoma diagnosis.
Chen H, Lai X, Zhu Y, Huang H, Zeng L, Zhang L
Clinical proteomics 2022 Nov 21;19(1):44
Clinical proteomics 2022 Nov 21;19(1):44
PHGDH expression increases with progression of Alzheimer's disease pathology and symptoms.
Chen X, Calandrelli R, Girardini J, Yan Z, Tan Z, Xu X, Hiniker A, Zhong S
Cell metabolism 2022 May 3;34(5):651-653
Cell metabolism 2022 May 3;34(5):651-653
Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway.
Soflaee MH, Kesavan R, Sahu U, Tasdogan A, Villa E, Djabari Z, Cai F, Tran DH, Vu HS, Ali ES, Rion H, O'Hara BP, Kelekar S, Hallett JH, Martin M, Mathews TP, Gao P, Asara JM, Manning BD, Ben-Sahra I, Hoxhaj G
Nature communications 2022 May 16;13(1):2698
Nature communications 2022 May 16;13(1):2698
PERK is a critical metabolic hub for immunosuppressive function in macrophages.
Raines LN, Zhao H, Wang Y, Chen HY, Gallart-Ayala H, Hsueh PC, Cao W, Koh Y, Alamonte-Loya A, Liu PS, Ivanisevic J, Lio CJ, Ho PC, Huang SC
Nature immunology 2022 Mar;23(3):431-445
Nature immunology 2022 Mar;23(3):431-445
Renal UTX-PHGDH-serine axis regulates metabolic disorders in the kidney and liver.
Chen H, Liu C, Wang Q, Xiong M, Zeng X, Yang D, Xie Y, Su H, Zhang Y, Huang Y, Chen Y, Yue J, Liu C, Wang S, Huang K, Zheng L
Nature communications 2022 Jul 4;13(1):3835
Nature communications 2022 Jul 4;13(1):3835
TFCP2, a binding protein of ATF3, promotes the progression of glioma by activating the synthesis of serine.
Luo X, Ge J, Liu J, Liu Z, Bi C, Lan S
Experimental cell research 2022 Jul 1;416(1):113136
Experimental cell research 2022 Jul 1;416(1):113136
Non-canonical phosphoglycerate dehydrogenase activity promotes liver cancer growth via mitochondrial translation and respiratory metabolism.
Shu Y, Hao Y, Feng J, Liu H, Li ST, Feng J, Jiang Z, Ye L, Zhou Y, Sun Y, Zhou Z, Wei H, Gao P, Zhang H, Sun L
The EMBO journal 2022 Dec 1;41(23):e111550
The EMBO journal 2022 Dec 1;41(23):e111550
The LINC00623/NAT10 signaling axis promotes pancreatic cancer progression by remodeling ac4C modification of mRNA.
Feng Z, Li K, Qin K, Liang J, Shi M, Ma Y, Zhao S, Liang H, Han D, Shen B, Peng C, Chen H, Jiang L
Journal of hematology & oncology 2022 Aug 17;15(1):112
Journal of hematology & oncology 2022 Aug 17;15(1):112
Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis.
Sun S, Li C, Cui K, Liu B, Zhou M, Cao Y, Zhang J, Bian Z, Fei B, Huang Z
Frontiers in cell and developmental biology 2021;9:770006
Frontiers in cell and developmental biology 2021;9:770006
CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.
Liu X, Liu Y, Liu Z, Lin C, Meng F, Xu L, Zhang X, Zhang C, Zhang P, Gong S, Wu N, Ren Z, Song J, Zhang Y
Molecular cancer 2021 Sep 8;20(1):114
Molecular cancer 2021 Sep 8;20(1):114
Interleukin-6 mediates PSAT1 expression and serine metabolism in TSC2-deficient cells.
Wang J, Filippakis H, Hougard T, Du H, Ye C, Liu HJ, Zhang L, Hindi K, Bagwe S, Nijmeh J, Asara JM, Shi W, El-Chemaly S, Henske EP, Lam HC
Proceedings of the National Academy of Sciences of the United States of America 2021 Sep 28;118(39)
Proceedings of the National Academy of Sciences of the United States of America 2021 Sep 28;118(39)
Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine.
Zhang Y, Yu H, Zhang J, Gao H, Wang S, Li S, Wei P, Liang J, Yu G, Wang X, Li X, Li D, Yang W
The Journal of clinical investigation 2021 Nov 1;131(21)
The Journal of clinical investigation 2021 Nov 1;131(21)
Extracellular vesicles derived from oesophageal cancer containing P4HB promote muscle wasting via regulating PHGDH/Bcl-2/caspase-3 pathway.
Gao X, Wang Y, Lu F, Chen X, Yang D, Cao Y, Zhang W, Chen J, Zheng L, Wang G, Fu M, Ma L, Song Y, Zhan Q
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Journal of extracellular vesicles 2021 Mar;10(5):e12060
Phgdh serves a protective role in Il‑1β induced chondrocyte inflammation and oxidative‑stress damage.
Huang H, Liu K, Ou H, Qian X, Wan J
Molecular medicine reports 2021 Jun;23(6)
Molecular medicine reports 2021 Jun;23(6)
Extracellular serine and glycine are required for mouse and human skeletal muscle stem and progenitor cell function.
Gheller BJ, Blum JE, Lim EW, Handzlik MK, Hannah Fong EH, Ko AC, Khanna S, Gheller ME, Bender EL, Alexander MS, Stover PJ, Field MS, Cosgrove BD, Metallo CM, Thalacker-Mercer AE
Molecular metabolism 2021 Jan;43:101106
Molecular metabolism 2021 Jan;43:101106
Serine Metabolism Controls Dental Pulp Stem Cell Aging by Regulating the DNA Methylation of p16.
Yang RL, Huang HM, Han CS, Cui SJ, Zhou YK, Zhou YH
Journal of dental research 2021 Jan;100(1):90-97
Journal of dental research 2021 Jan;100(1):90-97
Biophysical and biochemical properties of PHGDH revealed by studies on PHGDH inhibitors.
Tan Y, Zhou X, Gong Y, Gou K, Luo Y, Jia D, Dai L, Zhao Y, Sun Q
Cellular and molecular life sciences : CMLS 2021 Dec 31;79(1):27
Cellular and molecular life sciences : CMLS 2021 Dec 31;79(1):27
Energy stress-induced linc01564 activates the serine synthesis pathway and facilitates hepatocellular carcinogenesis.
Zhang G, Yang Y, Hu H, Liu K, Li B, Zhu Y, Wang Z, Wu Q, Mei Y
Oncogene 2021 Apr;40(16):2936-2951
Oncogene 2021 Apr;40(16):2936-2951
The Symbiotic Relationship between the Neural Retina and Retinal Pigment Epithelium Is Supported by Utilizing Differential Metabolic Pathways.
Sinha T, Naash MI, Al-Ubaidi MR
iScience 2020 Apr 24;23(4):101004
iScience 2020 Apr 24;23(4):101004
Berberine Inhibits Growth of Liver Cancer Cells by Suppressing Glutamine Uptake.
Zhang P, Wang Q, Lin Z, Yang P, Dou K, Zhang R
OncoTargets and therapy 2019;12:11751-11763
OncoTargets and therapy 2019;12:11751-11763
De novo synthesis of serine and glycine fuels purine nucleotide biosynthesis in human lung cancer tissues.
Fan TWM, Bruntz RC, Yang Y, Song H, Chernyavskaya Y, Deng P, Zhang Y, Shah PP, Beverly LJ, Qi Z, Mahan AL, Higashi RM, Dang CV, Lane AN
The Journal of biological chemistry 2019 Sep 6;294(36):13464-13477
The Journal of biological chemistry 2019 Sep 6;294(36):13464-13477
Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications.
Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, Yan R, Wang L, Zhang H, Zhong X, Gao P
Life science alliance 2019 Oct;2(5)
Life science alliance 2019 Oct;2(5)
The SIRT2/cMYC Pathway Inhibits Peroxidation-Related Apoptosis In Cholangiocarcinoma Through Metabolic Reprogramming.
Xu L, Wang L, Zhou L, Dorfman RG, Pan Y, Tang D, Wang Y, Yin Y, Jiang C, Zou X, Wu J, Zhang M
Neoplasia (New York, N.Y.) 2019 May;21(5):429-441
Neoplasia (New York, N.Y.) 2019 May;21(5):429-441
Azacoccone E inhibits cancer cell growth by targeting 3-phosphoglycerate dehydrogenase.
Guo J, Gu X, Zheng M, Zhang Y, Chen L, Li H
Bioorganic chemistry 2019 Jun;87:16-22
Bioorganic chemistry 2019 Jun;87:16-22
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer.
Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M, Lin SH, Huang M
Nature communications 2019 Jun 20;10(1):2701
Nature communications 2019 Jun 20;10(1):2701
A novel inhibitor of tumorspheres reveals the activation of the serine biosynthetic pathway upon mitochondrial inhibition.
Subedi A, Muroi M, Futamura Y, Kawamura T, Aono H, Nishi M, Ryo A, Watanabe N, Osada H
FEBS letters 2019 Apr;593(8):763-776
FEBS letters 2019 Apr;593(8):763-776
Inhibition of Phosphoglycerate Dehydrogenase Attenuates Bleomycin-induced Pulmonary Fibrosis.
Hamanaka RB, Nigdelioglu R, Meliton AY, Tian Y, Witt LJ, O'Leary E, Sun KA, Woods PS, Wu D, Ansbro B, Ard S, Rohde JM, Dulin NO, Guzy RD, Mutlu GM
American journal of respiratory cell and molecular biology 2018 May;58(5):585-593
American journal of respiratory cell and molecular biology 2018 May;58(5):585-593
Partial involvement of Nrf2 in skeletal muscle mitohormesis as an adaptive response to mitochondrial uncoupling.
Coleman V, Sa-Nguanmoo P, Koenig J, Schulz TJ, Grune T, Klaus S, Kipp AP, Ost M
Scientific reports 2018 Feb 5;8(1):2446
Scientific reports 2018 Feb 5;8(1):2446
Proximal tubule glutamine synthetase expression is necessary for the normal response to dietary protein restriction.
Lee HW, Osis G, Handlogten ME, Verlander JW, Weiner ID
American journal of physiology. Renal physiology 2017 Jul 1;313(1):F116-F125
American journal of physiology. Renal physiology 2017 Jul 1;313(1):F116-F125
Glyceraldehyde-3-phosphate dehydrogenase promotes liver tumorigenesis by modulating phosphoglycerate dehydrogenase.
Liu S, Sun Y, Jiang M, Li Y, Tian Y, Xue W, Ding N, Sun Y, Cheng C, Li J, Miao X, Liu X, Zheng L, Huang K
Hepatology (Baltimore, Md.) 2017 Aug;66(2):631-645
Hepatology (Baltimore, Md.) 2017 Aug;66(2):631-645
Muscle mitochondrial stress adaptation operates independently of endogenous FGF21 action.
Ost M, Coleman V, Voigt A, van Schothorst EM, Keipert S, van der Stelt I, Ringel S, Graja A, Ambrosi T, Kipp AP, Jastroch M, Schulz TJ, Keijer J, Klaus S
Molecular metabolism 2016 Feb;5(2):79-90
Molecular metabolism 2016 Feb;5(2):79-90
Transforming Growth Factor (TGF)-β Promotes de Novo Serine Synthesis for Collagen Production.
Nigdelioglu R, Hamanaka RB, Meliton AY, O'Leary E, Witt LJ, Cho T, Sun K, Bonham C, Wu D, Woods PS, Husain AN, Wolfgeher D, Dulin NO, Chandel NS, Mutlu GM
The Journal of biological chemistry 2016 Dec 30;291(53):27239-27251
The Journal of biological chemistry 2016 Dec 30;291(53):27239-27251
Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.
Ost M, Keipert S, van Schothorst EM, Donner V, van der Stelt I, Kipp AP, Petzke KJ, Jove M, Pamplona R, Portero-Otin M, Keijer J, Klaus S
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Apr;29(4):1314-28
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2015 Apr;29(4):1314-28
cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
Sun L, Song L, Wan Q, Wu G, Li X, Wang Y, Wang J, Liu Z, Zhong X, He X, Shen S, Pan X, Li A, Wang Y, Gao P, Tang H, Zhang H
Cell research 2015 Apr;25(4):429-44
Cell research 2015 Apr;25(4):429-44
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Jurkat cells were subjected to SDS PAGE followed by western blot with 14719-1-AP(PHGDH antibody) at dilution of 1:1200
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PHGDH antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human PHGDH. This antibody recognizes human,mouse,rat antigen. The PHGDH antibody has been validated for the following applications: ELISA, WB, IHC analysis.