55282-1-AP

antibody from Proteintech Group

Targeting: INSIG1 CL-6, MGC1405

Western blot (Data presented on provider website)

ELISA (Data presented on provider website)

Antibody Data

Product number

55282-1-AP

Provider

Proteintech Group

Product name

INSIG1 antibody

Antibody type

Polyclonal

Description

INSIG1 antibody (Cat. #55282-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Conjugate

Unconjugated

Isotype

IgG

Vial size

20ul, 150ul

References

Submitted references

Iron overload reprogramming lipid metabolism through the IRP1-SCAP axis in fibroblast-like synoviocytes aggravates bone destruction in rheumatoid arthritis.

Liu Y, Fang L, Wang M, Zhong S, Xiong Y, Hou Y, Ren J, Li Y, Zhu W, Meng X, Lu C, Pan Y
Experimental & molecular medicine 2026 May 1;

---

An integrative pharmacology-based study on the pharmacological activity and mechanism of xiaoji-chenpi formula (XCF) against MAFLD.

Liang S, Dong Y, Chang Z, Guo P, Jia J, Yang G, Chen Y, Dong L, Xu X, Cai T, Li T, Fang Y, Sun W, Li L, Wang C, Song X
Frontiers in pharmacology 2025;16:1521111

---

YY1/INSIG1 enhances atherosclerosis progression by regulating AMPK-mTOR signaling.

Yang M, Zhang J, Xu Z, Yang L, Tang S
Molecular immunology 2025 Oct;186:26-38

---

RORα fine-tunes the circadian control of hepatic triglyceride synthesis and gluconeogenesis.

Monnier C, Ganbold M, Auclair M, Roblot N, Boutin AB, Boutin PK, Fève B, Antoine B
Scientific reports 2025 Mar 26;15(1):10464

---

The SDF-1α/MTDH axis inhibits ferroptosis and promotes the formation of anti-VEGF-resistant choroidal neovascularization by facilitating the nuclear translocation of SREBP1.

Zou R, Zhang X, Dai X, Yuan Y, Dai J, Yuan F
Cell biology and toxicology 2025 Jul 17;41(1):118

---

A cholesterol-responsive hepatic tRNA-derived small RNA regulates cholesterol homeostasis and atherosclerosis development.

Li X, Hernandez R, Zhang X, Tang S, Yuan X, Wu J, Pham K, Rawal HC, Heinrich EC, Zhang S, Chen Q, Zhou T, Zhou C
Nature communications 2025 Dec 15;16(1):11043

---

Single-Cell Sequencing and Machine Learning Integration to Identify Candidate Biomarkers in Psoriasis: INSIG1.

Zhou X, Ning J, Cai R, Liu J, Yang H, Bai Y
Journal of inflammation research 2024;17:11485-11503

---

Tubular insulin-induced gene 1 deficiency promotes NAD(+) consumption and exacerbates kidney fibrosis.

Li S, Qin J, Zhao Y, Wang J, Huang S, Yu X
EMBO molecular medicine 2024 Jul;16(7):1675-1703

---

Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis.

Yang X, Gu C, Cai J, Li F, He X, Luo L, Xiao W, Hu B, Hu J, Qian H, Ren S, Zhang L, Zhu X, Yang L, Yang J, Yang Z, Zheng Y, Huang X, Wang Z
Redox biology 2024 Feb;69:103002

---

Porcine reproductive and respiratory syndrome virus activates lipid synthesis through a ROS-dependent AKT/PCK1/INSIG/SREBPs axis.

Ma YX, Han YQ, Wang PZ, Wang MY, Yang GY, Li JL, Wang J, Chu BB
International journal of biological macromolecules 2024 Dec;282(Pt 1):136720

---

C9orf72 controls hepatic lipid metabolism by regulating SREBP1 transport.

Wu Y, Zheng W, Xu G, Zhu L, Li Z, Chen J, Wang L, Chen S
Cell death and differentiation 2024 Aug;31(8):1070-1084

---

miR-32-5p induces hepatic steatosis and hyperlipidemia by triggering de novo lipogenesis.

Wang YD, Wu LL, Mai YN, Wang K, Tang Y, Wang QY, Li JY, Jiang LY, Liao ZZ, Hu C, Wang YY, Liu JJ, Liu JH, Xiao XH
Metabolism: clinical and experimental 2023 Sep;146:155660

---

Functional and miRNA regulatory characteristics of INSIG genes highlight the key role of lipid synthesis in the liver of chicken (Gallus gallus).

Yue Y, Liu Z, Zhang K, Jia Q, Wang D, Wang Z, Guo Y, Li D, Jiang R, Li Z, Tian Y, Kang X, Liu X, Li H
Poultry science 2023 Feb;102(2):102380

---

Dickkopf-1 promotes vascular smooth muscle cell foam cell formation and atherosclerosis development through CYP4A11/SREBP2/ABCA1.

Li X, Zheng T, Zhang Y, Zhao Y, Liu F, Dai S, Liu X, Zhang M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Aug;37(8):e23048

---

Acacetin protects against depression-associated dry eye disease by regulating ubiquitination of NLRP3 through gp78 signal.

Xie M, Wang H, Peng J, Qing D, Zhang X, Guo D, Meng P, Luo Z, Wang X, Peng Q
Frontiers in pharmacology 2022;13:984475

---

Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation.

Xu T, Yu W, Fang H, Wang Z, Chi Z, Guo X, Jiang D, Zhang K, Chen S, Li M, Guo Y, Zhang J, Yang D, Yu Q, Wang D, Zhang X
Cell death and differentiation 2022 Aug;29(8):1582-1595