Tissue expression
Cell line expression
Protein structure

INSIG1

Insulin induced gene 1
CL-6, MGC1405 
This gene encodes an endoplasmic reticulum membrane protein that regulates cholesterol metabolism, lipogenesis, and glucose homeostasis. The encoded protein has six transmembrane helices which contain an effector protein binding site. It binds the sterol-sensing domains of sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) and 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), and is essential for the sterol-mediated trafficking of these two proteins. It promotes the endoplasmic reticulum retention of SCAP and the ubiquitin-mediated degradation of HMG-CoA reductase. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]
More gene data

All Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antigen sequence

Epitope

Antibody

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
244 antibodies from 22 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Proteintech Group
2 antibodies
Biorbyt
31 antibodies
antibodies-online
92 antibodies
Invitrogen Antibodies
8 antibodies
Aviva Systems Biology
4 antibodies
Novus Biologicals
25 antibodies
GeneTex
5 antibodies
NovoPro Bioscience Inc.
2 antibodies
Cusabio Biotech Co., Ltd
4 antibodies
Abgent
1 antibody
Abnova Corporation
1 antibody
Affinity Biosciences
1 antibody
Wuhan Fine Biotech Co., Ltd.
1 antibody
OriGene
5 antibodies
NSJ Bioreagents
1 antibody
ProSci
1 antibody
MyBioSource
1 antibody
St John's Laboratory
1 antibody
Abbexa
4 antibodies
Creative Diagnostics
1 antibody
MilliporeSigma / Merck KGaA
3 antibodies