55206-1-AP

antibody from Proteintech Group

Targeting: PCSK9 FH3, HCHOLA3, NARC-1

Provider product page for 55206-1-AP

Western blot

ELISA

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [60]
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Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 55206-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#55206-1-AP, RRID:AB_10918272
Product name: PCSK9 antibody
Antibody type: Polyclonal
Description: KD/KO validated PCSK9 antibody (Cat. #55206-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

PCSK9 protein structure - 55206-1-AP shown in red.

Submitted references Polygoni Multiflori Radix Improves Dyslipidemia by Regulating Hepatocyte Lipid Metabolism Mediated via the AMPK/SREBP-2/PCSK9/LDLR Signaling Pathway.

Wang T, Zhang L, Wang Y, Xing J, Xu L, Hu X, Su W, Zheng R
Metabolites 2026 Mar 31;16(4)

Xia Ku Cao Paste restores intestinal microbiota homeostasis and improves hepatic metabolism disturbances to alleviate hyperlipidemia.

Du Z, Wang X, Xu L, Hu Z, Liu M, Min X, Hu J, Meng Y, Ye L, Liu S, Shi Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Apr;153:158010

Hepatocyte-Targeted Cyclic Peptide LYTACs for PCSK9 Degradation and LDL Cholesterol Metabolic Regulation.

Feng B, Shi Y, Xu J, Hu M, Liang S, Li Y, Gan W
ACS chemical biology 2026 Apr 17;21(4):801-811

Structural characterization, physicochemical properties and hypolipidemic activity of hemp (Cannabis sativa L.) protein hydrolysates prepared via enzyme-microbial synergy.

Zhao Y, Liu M, Zang X, Li J, Zhang G, Du P, Zhang T, Sun X, Li C, Liu L
Food research international (Ottawa, Ont.) 2026 Apr 1;229:118355

WTAP Silencing protects human aortic smooth muscle cells from angiotensin II-induced senescence, apoptosis, ferroptosis, and inflammation by regulating PCSK9.

Pang H, Fu B, Wang P, Meng Y, Xie P, Hu X, Ma Q
Journal of bioenergetics and biomembranes 2025 Oct;57(4-5):231-244

A High-Fat Diet Damages the Blood-Testis Barrier Through the PCSK9-LOX1 Positive Feedback Loop in Sertoli Cells.

Zhang G, Wang Z, He M, Kong L, Yushanjiang S, Jin L, Zhao R, Ma Z, Pan Y, Hu Y, Nie L, Yuan D
Reproductive sciences (Thousand Oaks, Calif.) 2025 Nov;32(11):3587-3598

A dual-targeting bio-liposomes nanodrug repair endothelial cell dysfunction and restore macrophage cholesterol flow homeostasis to treat early atherosclerosis.

Zhang Q, Ma S, Kang X, Liu Y, Ma F, Yu F, Luo X, Li G, Hao Y, Zhang H, Liu B, Jiang Y
Journal of nanobiotechnology 2025 May 20;23(1):365

Unraveling Estrogen and PCSK9's Roles in Lipid Metabolism Disorders among Ovariectomized Mice.

Yang J, Xu M, Wang Z, He M, Zhang G, Jin L, Zhao R, Pan Y, Tong J, Nie L
Reproductive sciences (Thousand Oaks, Calif.) 2025 Feb;32(2):316-325

Vitisin A Outperforms Cyanidin-3-O-Glucoside in Triglyceride Reduction by Modulating Hepatic Lipogenesis and Fatty Acid β-Oxidation.

Li Y, Li X, Liu J, Jayavanth P, Bai W, Jiao R
International journal of molecular sciences 2025 Feb 11;26(4)

IMM-H007 promotes hepatic cholesterol and triglyceride metabolism by activating AMPKα to attenuate hypercholesterolemia.

Li J, Wang M, Qu K, Sun Y, Yin Z, Dong N, Sun X, Xu Y, Chen L, Zhang S, Xian X, Xu S, Ma L, Duan Y, Zhu H
Acta pharmaceutica Sinica. B 2025 Aug;15(8):4047-4063

Effect of lycium barbarum polysaccharide on ameliorating high-fat diet-damaged spermatogenesis via PCSK9 and TLR4 signaling pathways in obese mice.

Wang J, Chen Y, Ni R, Su M, Cao Y, Zhou R, Li X, Li J, Tang Y, Tang J, Wang S, Tang L, Chen R, Wang H, Tang L
Molecular biology reports 2025 Aug 18;52(1):832

Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Is Associated With Recurrence and Survival of Resectable Non-Small Cell Lung Cancer (NSCLC): A Retrospective Study.

Gao X, Yi L, Fu S, Lu Z, Wang J, Zhang S
The Journal of surgical research 2024 Sep;301:231-239

Integrated bioinformatics analysis identifies PCSK9 as a prognosticator correlated with lipid metabolism in pancreatic adenocarcinoma.

Zhou S, Guo Q, Chen A, Li X, Zou X
World journal of surgical oncology 2024 Sep 28;22(1):256

A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis.

Wang WZ, Liu C, Luo JQ, Lei LJ, Chen MH, Zhang YY, Sheng R, Li YN, Wang L, Jiang XH, Xiao TM, Zhang YH, Li SW, Wu YX, Xu Y, Xu YN, Si SY
Acta pharmacologica Sinica 2024 Oct;45(10):2119-2133

Sesamin alleviates lipid accumulation induced by oleic acid via PINK1/Parkin-mediated mitophagy in HepG2 cells.

Dong M, Zhang T, Liang X, Cheng X, Shi F, Yuan H, Zhang F, Jiang Q, Wang X
Biochemical and biophysical research communications 2024 May 14;708:149815

A comparative study of the hypolipidemic effects and mechanisms of action of Laminaria japonica- and Ascophyllum nodosum-derived fucoidans in apolipoprotein E-deficient mice.

Liu T, Wang X, Wang YM, Sui FR, Zhang XY, Liu HD, Ma DY, Liu XX, Guo SD
Food & function 2024 Jun 4;15(11):5955-5971

Exserolide J ameliorates lipid accumulation in vitro by regulating liver X receptor alpha and peroxisome proliferator-activated receptor alpha proteins.

Zhang Y, Wang X, Liu T, Zhang ZY, Song WG, Guo SD
Heliyon 2024 Jun 15;10(11):e31861

PCSK9 aggravated carotid artery stenosis in ApoE(-/-) mice by promoting the expression of tissue factors in endothelial cells via the TLR4/NF-κB pathway.

Peng C, Li J, Chen Y, Zhang HR, Li TX, Jiang YH, Yang XY, Zhao Y
Biochemical pharmacology 2024 Jul;225:116314

Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.

Ouyang Z, Ma M, Zhang Z, Wu H, Xue Y, Jian Y, Yin K, Yu S, Zhao C, Guo W, Gu X
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449

Nilotinib boosts the efficacy of anti-PDL1 therapy in colorectal cancer by restoring the expression of MHC-I.

Dong H, Wen C, He L, Zhang J, Xiang N, Liang L, Hu L, Li W, Liu J, Shi M, Hu Y, Chen S, Liu H, Yang X
Journal of translational medicine 2024 Aug 14;22(1):769

Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.

Jin Q, Zhang C, Chen R, Jiang L, Li H, Wu P, Li L
Journal of translational medicine 2024 Apr 15;22(1):352

PCSK9 regulates the efficacy of immune checkpoint therapy in lung cancer.

Gao X, Yi L, Jiang C, Li S, Wang X, Yang B, Li W, Che N, Wang J, Zhang H, Zhang S
Frontiers in immunology 2023;14:1142428

A strategy for Cas13 miniaturization based on the structure and AlphaFold.

Zhao F, Zhang T, Sun X, Zhang X, Chen L, Wang H, Li J, Fan P, Lai L, Sui T, Li Z
Nature communications 2023 Sep 8;14(1):5545

Protective effect of evolocumab on Müller cells in the rat retina under hyperglycaemic and hypoxic conditions.

Zhou Q, Tang H, Li S
Journal of diabetes and its complications 2023 Oct;37(10):108593

RETRACTED ARTICLE: circABCA3 knockdown relieves hypoxia-induced human cardiac microvascular endothelial cell dysfunction by targeting the miR-671-5p/PCSK9 axis.

Hui H, Zhao G, Du M, Yu Q
Cell stress & chaperones 2023 Nov;28(6):1069

Evolocumab loaded Bio-Liposomes for efficient atherosclerosis therapy.

Li Z, Zhu H, Liu H, Liu D, Liu J, Jiang J, Zhang Y, Qin Z, Xu Y, Peng Y, Liu B, Long Y
Journal of nanobiotechnology 2023 May 19;21(1):158

Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation.

Abdelwahed KS, Siddique AB, Ebrahim HY, Qusa MH, Mudhish EA, Rad AH, Zerfaoui M, Abd Elmageed ZY, El Sayed KA
Marine drugs 2023 Mar 28;21(4)

Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage.

Wang Y, Zhang L, Lv L, Zhou Z, Xi H
Journal of biochemical and molecular toxicology 2023 Jun;37(6):e23346

Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.

Guo HH, Shen HR, Wang LL, Luo ZG, Zhang JL, Zhang HJ, Gao TL, Han YX, Jiang JD
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114754

Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.

Zhang Y, Feng W, Wang Z, Pang Y, Jin Y, Chen S, Ding S, Wang T, Zou Y, Sun P, Chen Y, Feng H, Huang H, Sheng C, Xiao M
Lab animal 2023 Feb;52(2):37-50

Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.

Yuan Y, Zhu Y, Li Y, Li X, Jiao R, Bai W
International journal of molecular sciences 2023 Feb 7;24(4)

Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways.

Yuefeng Y, Zhiqi L, Yi C, Keyu Z, Heng W, Yuying W, Ningjian W, Yuetian Y, Xinjie G, Yihao Z, Yingli L, Fangzhen X
International journal of endocrinology 2022;2022:7989751

Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.

He H, Liu M, He R, Zhao W
Food & function 2022 Oct 3;13(19):10265-10274

A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis.

Stomberski CT, Venetos NM, Zhou HL, Qian Z, Collison BR, Field SJ, Premont RT, Stamler JS
Cell reports 2022 Oct 25;41(4):111538

Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis.

Alannan M, Fatrouni H, Trézéguet V, Dittrich-Domergue F, Moreau P, Siegfried G, Liet B, Khatib AM, Grosset CF, Badran B, Fayyad-Kazan H, Merched AJ
Cells 2022 Dec 23;12(1)

Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer.

Alannan M, Trézéguet V, Amoêdo ND, Rossignol R, Mahfouf W, Rezvani HR, Dittrich-Domergue F, Moreau P, Lacomme S, Gontier E, Grosset CF, Badran B, Fayyad-Kazan H, Merched AJ
Cancers 2022 Dec 20;15(1)

PCSK9 Suppresses M2-Like Tumor-Associated Macrophage Polarization by Regulating the Secretion of OX40L from Hepatocellular Carcinoma Cells.

Hu J, Zhang M, Gui L, Wan Q, Zhong J, Bai L, He M
Immunological investigations 2022 Aug;51(6):1678-1693

Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity.

Chen PW, Tseng SY, Chang HY, Lee CH, Chao TH
International journal of molecular sciences 2022 Aug 29;23(17)

The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR((-/-)) Mice by Improving Hyperlipidemia.

Yin F, Lin P, Yu WQ, Shen N, Li Y, Guo SD
Frontiers in molecular biosciences 2021;8:783807

Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.

Zhang XM, Gu YH, Deng H, Xu ZQ, Zhong ZY, Lyu XJ, Jin HM, Yang XH
Frontiers in cardiovascular medicine 2021;8:691336

Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.

Barisione C, Verzola D, Garibaldi S, Ferrari PF, Garibotto G, Ameri P, Pane B, Spinella G, Pratesi G, Palombo D
International journal of molecular sciences 2021 Sep 13;22(18)

Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.

Wang J, Wang Y, Yang X, Lin P, Liu N, Li X, Zhang B, Guo S
International journal of biological macromolecules 2021 May 15;179:407-417

PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma.

Zhang SZ, Zhu XD, Feng LH, Li XL, Liu XF, Sun HC, Tang ZY
Experimental hematology & oncology 2021 Mar 31;10(1):25

Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.

Yang X, Lin P, Wang J, Liu N, Yin F, Shen N, Guo S
International journal of biological macromolecules 2021 Jun 30;181:890-904

Polysaccharide CM1 from Cordyceps militaris hinders adipocyte differentiation and alleviates hyperlipidemia in LDLR((+/-)) hamsters.

Yu WQ, Yin F, Shen N, Lin P, Xia B, Li YJ, Guo SD
Lipids in health and disease 2021 Dec 13;20(1):178

PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.

Zeng J, Tao J, Xi L, Wang Z, Liu L
International journal of molecular medicine 2021 Apr;47(4)

Hepatic cholesterol synthesis and lipoprotein levels impaired by dietary fructose and saturated fatty acids in mice: Insight on PCSK9 and CD36.

Nergiz-Unal R, Ulug E, Kisioglu B, Tamer F, Bodur M, Yalcimin H, Yuruk AA
Nutrition (Burbank, Los Angeles County, Calif.) 2020 Nov-Dec;79-80:110954

Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.

Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882

Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells.

Choi YJ, Lee SJ, Kim HI, Lee HJ, Kang SJ, Kim TY, Cheon C, Ko SG
Scientific reports 2020 Nov 16;10(1):19834

The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα.

Li T, Hu SM, Pang XY, Wang JF, Yin JY, Li FH, Wang J, Yang XQ, Xia B, Liu YH, Song WG, Guo SD
Journal of cellular and molecular medicine 2020 Mar;24(6):3384-3398

Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.

Liu X, Bao X, Hu M, Chang H, Jiao M, Cheng J, Xie L, Huang Q, Li F, Li CY
Nature 2020 Dec;588(7839):693-698

Prognostic Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma.

He L, Chen J, Xu F, Li J, Li J
Molecular therapy oncolytics 2020 Dec 16;19:265-277

Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome.

Wang M, Zhao D, Xu L, Guo W, Nie L, Lei Y, Long Y, Liu M, Wang Y, Zhang X, Zhang L, Li H, Zhang J, Yuan D, Yue L
Metabolism: clinical and experimental 2019 May;94:47-58

Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.

Xiao J, Bai XQ, Liao L, Zhou M, Peng J, Xiang Q, Ren Z, Wen HY, Jiang ZS, Tang ZH, Wang MM, Liu LS
International journal of molecular medicine 2019 May;43(5):2055-2063

Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet.

Yang Z, Liu G, Wang Y, Yin J, Wang J, Xia B, Li T, Yang X, Hou P, Hu S, Song W, Guo S
Journal of agricultural and food chemistry 2019 May 22;67(20):5782-5791

Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells.

Cao S, Xu P, Yan J, Liu H, Liu L, Cheng L, Qiu F, Kang N
Journal of cellular biochemistry 2019 Feb;120(2):1340-1349

The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice.

Yin J, Wang J, Li F, Yang Z, Yang X, Sun W, Xia B, Li T, Song W, Guo S
Food & function 2019 Aug 1;10(8):5124-5139

Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.

Wang Y, Wu T, Hu D, Weng X, Wang X, Chen PJ, Luo X, Wang H, Ning Q
Journal of lipid research 2018 Jan;59(1):58-68

PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.

Liu LS, Bai XQ, Gao Y, Wu Q, Ren Z, Li Q, Pan LH, He NY, Peng J, Tang ZH
Journal of Alzheimer's disease : JAD 2017;57(3):723-734

Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression.

Zhao XS, Wu Q, Peng J, Pan LH, Ren Z, Liu HT, Jiang ZS, Wang GX, Tang ZH, Liu LS
Molecular medicine reports 2017 Feb;15(2):712-718

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: COLO 320 cells were subjected to SDS PAGE followed by western blot with 55206-1-AP(PCSK9 antibody) at dilution of 1:500
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human colon cancer using 55206-1-AP(PCSK9 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The PCSK9 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PCSK9. This antibody recognizes human,mouse,rat antigen. The PCSK9 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 55206-1-AP.pdf

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