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- Antigen structure
- References [41]
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- Western blot [1]
- Immunohistochemistry [2]
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- Product number
- 55206-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#55206-1-AP, RRID:AB_10918272
- Product name
- PCSK9 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated PCSK9 antibody (Cat. #55206-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Sesamin alleviates lipid accumulation induced by oleic acid via PINK1/Parkin-mediated mitophagy in HepG2 cells.
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.
PCSK9 regulates the efficacy of immune checkpoint therapy in lung cancer.
A strategy for Cas13 miniaturization based on the structure and AlphaFold.
Protective effect of evolocumab on Müller cells in the rat retina under hyperglycaemic and hypoxic conditions.
RETRACTED ARTICLE: circABCA3 knockdown relieves hypoxia-induced human cardiac microvascular endothelial cell dysfunction by targeting the miR-671-5p/PCSK9 axis.
Evolocumab loaded Bio-Liposomes for efficient atherosclerosis therapy.
Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation.
Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage.
Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.
Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways.
Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.
A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis.
Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis.
Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer.
PCSK9 Suppresses M2-Like Tumor-Associated Macrophage Polarization by Regulating the Secretion of OX40L from Hepatocellular Carcinoma Cells.
Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity.
The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR((-/-)) Mice by Improving Hyperlipidemia.
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.
Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.
PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma.
Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Hepatic cholesterol synthesis and lipoprotein levels impaired by dietary fructose and saturated fatty acids in mice: Insight on PCSK9 and CD36.
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells.
The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα.
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Prognostic Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma.
Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome.
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.
Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet.
Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells.
The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice.
Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.
PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.
Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression.
Dong M, Zhang T, Liang X, Cheng X, Shi F, Yuan H, Zhang F, Jiang Q, Wang X
Biochemical and biophysical research communications 2024 May 14;708:149815
Biochemical and biophysical research communications 2024 May 14;708:149815
Targeted Degradation of PCSK9 In Vivo by Autophagy-Tethering Compounds.
Ouyang Z, Ma M, Zhang Z, Wu H, Xue Y, Jian Y, Yin K, Yu S, Zhao C, Guo W, Gu X
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Journal of medicinal chemistry 2024 Jan 11;67(1):433-449
Quinic acid regulated TMA/TMAO-related lipid metabolism and vascular endothelial function through gut microbiota to inhibit atherosclerotic.
Jin Q, Zhang C, Chen R, Jiang L, Li H, Wu P, Li L
Journal of translational medicine 2024 Apr 15;22(1):352
Journal of translational medicine 2024 Apr 15;22(1):352
PCSK9 regulates the efficacy of immune checkpoint therapy in lung cancer.
Gao X, Yi L, Jiang C, Li S, Wang X, Yang B, Li W, Che N, Wang J, Zhang H, Zhang S
Frontiers in immunology 2023;14:1142428
Frontiers in immunology 2023;14:1142428
A strategy for Cas13 miniaturization based on the structure and AlphaFold.
Zhao F, Zhang T, Sun X, Zhang X, Chen L, Wang H, Li J, Fan P, Lai L, Sui T, Li Z
Nature communications 2023 Sep 8;14(1):5545
Nature communications 2023 Sep 8;14(1):5545
Protective effect of evolocumab on Müller cells in the rat retina under hyperglycaemic and hypoxic conditions.
Zhou Q, Tang H, Li S
Journal of diabetes and its complications 2023 Oct;37(10):108593
Journal of diabetes and its complications 2023 Oct;37(10):108593
RETRACTED ARTICLE: circABCA3 knockdown relieves hypoxia-induced human cardiac microvascular endothelial cell dysfunction by targeting the miR-671-5p/PCSK9 axis.
Hui H, Zhao G, Du M, Yu Q
Cell stress & chaperones 2023 Nov;28(6):1069
Cell stress & chaperones 2023 Nov;28(6):1069
Evolocumab loaded Bio-Liposomes for efficient atherosclerosis therapy.
Li Z, Zhu H, Liu H, Liu D, Liu J, Jiang J, Zhang Y, Qin Z, Xu Y, Peng Y, Liu B, Long Y
Journal of nanobiotechnology 2023 May 19;21(1):158
Journal of nanobiotechnology 2023 May 19;21(1):158
Pseurotin A Validation as a Metastatic Castration-Resistant Prostate Cancer Recurrence-Suppressing Lead via PCSK9-LDLR Axis Modulation.
Abdelwahed KS, Siddique AB, Ebrahim HY, Qusa MH, Mudhish EA, Rad AH, Zerfaoui M, Abd Elmageed ZY, El Sayed KA
Marine drugs 2023 Mar 28;21(4)
Marine drugs 2023 Mar 28;21(4)
Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage.
Wang Y, Zhang L, Lv L, Zhou Z, Xi H
Journal of biochemical and molecular toxicology 2023 Jun;37(6):e23346
Journal of biochemical and molecular toxicology 2023 Jun;37(6):e23346
Berberine is a potential alternative for metformin with good regulatory effect on lipids in treating metabolic diseases.
Guo HH, Shen HR, Wang LL, Luo ZG, Zhang JL, Zhang HJ, Gao TL, Han YX, Jiang JD
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114754
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Jul;163:114754
Early growth response 2 in the mPFC regulates mouse social and cooperative behaviors.
Zhang Y, Feng W, Wang Z, Pang Y, Jin Y, Chen S, Ding S, Wang T, Zou Y, Sun P, Chen Y, Feng H, Huang H, Sheng C, Xiao M
Lab animal 2023 Feb;52(2):37-50
Lab animal 2023 Feb;52(2):37-50
Cholesterol-Lowering Activity of Vitisin A Is Mediated by Inhibiting Cholesterol Biosynthesis and Enhancing LDL Uptake in HepG2 Cells.
Yuan Y, Zhu Y, Li Y, Li X, Jiao R, Bai W
International journal of molecular sciences 2023 Feb 7;24(4)
International journal of molecular sciences 2023 Feb 7;24(4)
Testosterone Deficiency Promotes Hypercholesteremia and Attenuates Cholesterol Liver Uptake via AR/PCSK9/LDLR Pathways.
Yuefeng Y, Zhiqi L, Yi C, Keyu Z, Heng W, Yuying W, Ningjian W, Yuetian Y, Xinjie G, Yihao Z, Yingli L, Fangzhen X
International journal of endocrinology 2022;2022:7989751
International journal of endocrinology 2022;2022:7989751
Lipid-lowering activity of metformin-soluble soybean polysaccharide nanoparticles.
He H, Liu M, He R, Zhao W
Food & function 2022 Oct 3;13(19):10265-10274
Food & function 2022 Oct 3;13(19):10265-10274
A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis.
Stomberski CT, Venetos NM, Zhou HL, Qian Z, Collison BR, Field SJ, Premont RT, Stamler JS
Cell reports 2022 Oct 25;41(4):111538
Cell reports 2022 Oct 25;41(4):111538
Targeting PCSK9 in Liver Cancer Cells Triggers Metabolic Exhaustion and Cell Death by Ferroptosis.
Alannan M, Fatrouni H, Trézéguet V, Dittrich-Domergue F, Moreau P, Siegfried G, Liet B, Khatib AM, Grosset CF, Badran B, Fayyad-Kazan H, Merched AJ
Cells 2022 Dec 23;12(1)
Cells 2022 Dec 23;12(1)
Rewiring Lipid Metabolism by Targeting PCSK9 and HMGCR to Treat Liver Cancer.
Alannan M, Trézéguet V, Amoêdo ND, Rossignol R, Mahfouf W, Rezvani HR, Dittrich-Domergue F, Moreau P, Lacomme S, Gontier E, Grosset CF, Badran B, Fayyad-Kazan H, Merched AJ
Cancers 2022 Dec 20;15(1)
Cancers 2022 Dec 20;15(1)
PCSK9 Suppresses M2-Like Tumor-Associated Macrophage Polarization by Regulating the Secretion of OX40L from Hepatocellular Carcinoma Cells.
Hu J, Zhang M, Gui L, Wan Q, Zhong J, Bai L, He M
Immunological investigations 2022 Aug;51(6):1678-1693
Immunological investigations 2022 Aug;51(6):1678-1693
Diverse Effects of Cilostazol on Proprotein Convertase Subtilisin/Kexin Type 9 between Obesity and Non-Obesity.
Chen PW, Tseng SY, Chang HY, Lee CH, Chao TH
International journal of molecular sciences 2022 Aug 29;23(17)
International journal of molecular sciences 2022 Aug 29;23(17)
The Cordyceps militaris-Derived Polysaccharide CM1 Alleviates Atherosclerosis in LDLR((-/-)) Mice by Improving Hyperlipidemia.
Yin F, Lin P, Yu WQ, Shen N, Li Y, Guo SD
Frontiers in molecular biosciences 2021;8:783807
Frontiers in molecular biosciences 2021;8:783807
Plasma Purification Treatment Relieves the Damage of Hyperlipidemia to PBMCs.
Zhang XM, Gu YH, Deng H, Xu ZQ, Zhong ZY, Lyu XJ, Jin HM, Yang XH
Frontiers in cardiovascular medicine 2021;8:691336
Frontiers in cardiovascular medicine 2021;8:691336
Renal Ischemia/Reperfusion Early Induces Myostatin and PCSK9 Expression in Rat Kidneys and HK-2 Cells.
Barisione C, Verzola D, Garibaldi S, Ferrari PF, Garibotto G, Ameri P, Pane B, Spinella G, Pratesi G, Palombo D
International journal of molecular sciences 2021 Sep 13;22(18)
International journal of molecular sciences 2021 Sep 13;22(18)
Purification, structural characterization, and PCSK9 secretion inhibitory effect of the novel alkali-extracted polysaccharide from Cordyceps militaris.
Wang J, Wang Y, Yang X, Lin P, Liu N, Li X, Zhang B, Guo S
International journal of biological macromolecules 2021 May 15;179:407-417
International journal of biological macromolecules 2021 May 15;179:407-417
PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma.
Zhang SZ, Zhu XD, Feng LH, Li XL, Liu XF, Sun HC, Tang ZY
Experimental hematology & oncology 2021 Mar 31;10(1):25
Experimental hematology & oncology 2021 Mar 31;10(1):25
Purification, characterization and anti-atherosclerotic effects of the polysaccharides from the fruiting body of Cordyceps militaris.
Yang X, Lin P, Wang J, Liu N, Yin F, Shen N, Guo S
International journal of biological macromolecules 2021 Jun 30;181:890-904
International journal of biological macromolecules 2021 Jun 30;181:890-904
PCSK9 mediates the oxidative low‑density lipoprotein‑induced pyroptosis of vascular endothelial cells via the UQCRC1/ROS pathway.
Zeng J, Tao J, Xi L, Wang Z, Liu L
International journal of molecular medicine 2021 Apr;47(4)
International journal of molecular medicine 2021 Apr;47(4)
Hepatic cholesterol synthesis and lipoprotein levels impaired by dietary fructose and saturated fatty acids in mice: Insight on PCSK9 and CD36.
Nergiz-Unal R, Ulug E, Kisioglu B, Tamer F, Bodur M, Yalcimin H, Yuruk AA
Nutrition (Burbank, Los Angeles County, Calif.) 2020 Nov-Dec;79-80:110954
Nutrition (Burbank, Los Angeles County, Calif.) 2020 Nov-Dec;79-80:110954
Ascorbic acid enhances low-density lipoprotein receptor expression by suppressing proprotein convertase subtilisin/kexin 9 expression.
Wang D, Yang X, Chen Y, Gong K, Yu M, Gao Y, Wu X, Hu H, Liao C, Han J, Duan Y
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
The Journal of biological chemistry 2020 Nov 20;295(47):15870-15882
Platycodin D enhances LDLR expression and LDL uptake via down-regulation of IDOL mRNA in hepatic cells.
Choi YJ, Lee SJ, Kim HI, Lee HJ, Kang SJ, Kim TY, Cheon C, Ko SG
Scientific reports 2020 Nov 16;10(1):19834
Scientific reports 2020 Nov 16;10(1):19834
The marine-derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα.
Li T, Hu SM, Pang XY, Wang JF, Yin JY, Li FH, Wang J, Yang XQ, Xia B, Liu YH, Song WG, Guo SD
Journal of cellular and molecular medicine 2020 Mar;24(6):3384-3398
Journal of cellular and molecular medicine 2020 Mar;24(6):3384-3398
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Liu X, Bao X, Hu M, Chang H, Jiao M, Cheng J, Xie L, Huang Q, Li F, Li CY
Nature 2020 Dec;588(7839):693-698
Nature 2020 Dec;588(7839):693-698
Prognostic Implication of a Metabolism-Associated Gene Signature in Lung Adenocarcinoma.
He L, Chen J, Xu F, Li J, Li J
Molecular therapy oncolytics 2020 Dec 16;19:265-277
Molecular therapy oncolytics 2020 Dec 16;19:265-277
Role of PCSK9 in lipid metabolic disorders and ovarian dysfunction in polycystic ovary syndrome.
Wang M, Zhao D, Xu L, Guo W, Nie L, Lei Y, Long Y, Liu M, Wang Y, Zhang X, Zhang L, Li H, Zhang J, Yuan D, Yue L
Metabolism: clinical and experimental 2019 May;94:47-58
Metabolism: clinical and experimental 2019 May;94:47-58
Hydrogen sulfide inhibits PCSK9 expression through the PI3K/Akt‑SREBP‑2 signaling pathway to influence lipid metabolism in HepG2 cells.
Xiao J, Bai XQ, Liao L, Zhou M, Peng J, Xiang Q, Ren Z, Wen HY, Jiang ZS, Tang ZH, Wang MM, Liu LS
International journal of molecular medicine 2019 May;43(5):2055-2063
International journal of molecular medicine 2019 May;43(5):2055-2063
Fucoidan A2 from the Brown Seaweed Ascophyllum nodosum Lowers Lipid by Improving Reverse Cholesterol Transport in C57BL/6J Mice Fed a High-Fat Diet.
Yang Z, Liu G, Wang Y, Yin J, Wang J, Xia B, Li T, Yang X, Hou P, Hu S, Song W, Guo S
Journal of agricultural and food chemistry 2019 May 22;67(20):5782-5791
Journal of agricultural and food chemistry 2019 May 22;67(20):5782-5791
Berberrubine and its analog, hydroxypropyl-berberrubine, regulate LDLR and PCSK9 expression via the ERK signal pathway to exert cholesterol-lowering effects in human hepatoma HepG2 cells.
Cao S, Xu P, Yan J, Liu H, Liu L, Cheng L, Qiu F, Kang N
Journal of cellular biochemistry 2019 Feb;120(2):1340-1349
Journal of cellular biochemistry 2019 Feb;120(2):1340-1349
The fucoidan from the brown seaweed Ascophyllum nodosum ameliorates atherosclerosis in apolipoprotein E-deficient mice.
Yin J, Wang J, Li F, Yang Z, Yang X, Sun W, Xia B, Li T, Song W, Guo S
Food & function 2019 Aug 1;10(8):5124-5139
Food & function 2019 Aug 1;10(8):5124-5139
Intracellular hepatitis B virus increases hepatic cholesterol deposition in alcoholic fatty liver via hepatitis B core protein.
Wang Y, Wu T, Hu D, Weng X, Wang X, Chen PJ, Luo X, Wang H, Ning Q
Journal of lipid research 2018 Jan;59(1):58-68
Journal of lipid research 2018 Jan;59(1):58-68
PCSK9 Promotes oxLDL-Induced PC12 Cell Apoptosis Through the Bcl-2/Bax-Caspase 9/3 Signaling Pathway.
Liu LS, Bai XQ, Gao Y, Wu Q, Ren Z, Li Q, Pan LH, He NY, Peng J, Tang ZH
Journal of Alzheimer's disease : JAD 2017;57(3):723-734
Journal of Alzheimer's disease : JAD 2017;57(3):723-734
Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression.
Zhao XS, Wu Q, Peng J, Pan LH, Ren Z, Liu HT, Jiang ZS, Wang GX, Tang ZH, Liu LS
Molecular medicine reports 2017 Feb;15(2):712-718
Molecular medicine reports 2017 Feb;15(2):712-718
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- COLO 320 cells were subjected to SDS PAGE followed by western blot with 55206-1-AP(PCSK9 antibody) at dilution of 1:500
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human colon cancer using 55206-1-AP(PCSK9 antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The PCSK9 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human PCSK9. This antibody recognizes human,mouse,rat antigen. The PCSK9 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
