GTX70232

Chou HC, Lu CH, Su YC, Lin LH, Yu HI, Chuang HH, Tsai YT, Liao EC, Wei YS, Yang YT, Chien YA, Yu XR, Lee YR, Chan HL
Life sciences 2018 Aug 15;207:184-204

YC-1 inhibits proliferation of breast cancer cells by down-regulating EZH2 expression via activation of c-Cbl and ERK.

Chang LC, Lin HY, Tsai MT, Chou RH, Lee FY, Teng CM, Hsieh MT, Hung HY, Huang LJ, Yu YL, Kuo SC
British journal of pharmacology 2014 Sep;171(17):4010-25

Mitochondrial genome instability resulting from SUV3 haploinsufficiency leads to tumorigenesis and shortened lifespan.

Chen PL, Chen CF, Chen Y, Guo XE, Huang CK, Shew JY, Reddick RL, Wallace DC, Lee WH
Oncogene 2013 Feb 28;32(9):1193-201

Molecular mechanism for age-related memory loss: the histone-binding protein RbAp48.

Pavlopoulos E, Jones S, Kosmidis S, Close M, Kim C, Kovalerchik O, Small SA, Kandel ER
Science translational medicine 2013 Aug 28;5(200):200ra115

ATF-2 regulates lipopolysaccharide-induced transcription in macrophage cells.

Hirose N, Maekawa T, Shinagawa T, Ishii S
Biochemical and biophysical research communications 2009 Jul 17;385(1):72-7

Interaction of histone acetylases and deacetylases in vivo.

Yamagoe S, Kanno T, Kanno Y, Sasaki S, Siegel RM, Lenardo MJ, Humphrey G, Wang Y, Nakatani Y, Howard BH, Ozato K
Molecular and cellular biology 2003 Feb;23(3):1025-33

Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex.

Zegerman P, Canas B, Pappin D, Kouzarides T
The Journal of biological chemistry 2002 Apr 5;277(14):11621-4

The histone deacetylase HDAC3 targets RbAp48 to the retinoblastoma protein.

Nicolas E, Ait-Si-Ali S, Trouche D
Nucleic acids research 2001 Aug 1;29(15):3131-6

RbAp48 belongs to the histone deacetylase complex that associates with the retinoblastoma protein.

Nicolas E, Morales V, Magnaghi-Jaulin L, Harel-Bellan A, Richard-Foy H, Trouche D
The Journal of biological chemistry 2000 Mar 31;275(13):9797-804

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Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Sample (30 ug of whole cell lysate) A: Hela 10% SDS PAGE GTX70232 diluted at 1:500
Validation comment: WB

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: HeLa whole cell and nuclear extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with RbAp48 antibody [11G10] (GTX70232) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: SH-SY5Y whole cell and nuclear extracts (30 ?g) were separated by 10% SDS-PAGE, and the membrane was blotted with RbAp48 antibody [11G10] (GTX70232) diluted at 1:500. The HRP-conjugated anti-mouse IgG antibody (GTX213111-01) was used to detect the primary antibody.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: Immunofluorescence analysis of HeLa, using RbAp48(GTX70232) antibody at 1:100 dilution.

Supportive validation

Submitted by: GeneTex (provider)
Main image
Experimental details: RbAp48 antibody immunoprecipitates RbAp48 protein-DNA in ChIP experiments. ChIP Sample: HeLa whole cell lysate/extract A. 5 £gg preimmune mouse IgG B. 5 £gg of RbAp48 antibody (GTX70232) The precipitated DNA was detected by PCR with primer set targeting to SOX9 gene locus.