MRAS

This gene encodes a member of the Ras family of small GTPases. These membrane-associated proteins function as signal transducers in multiple processes including cell growth and differentiation, and dysregulation of Ras signaling has been associated with many types of cancer. The encoded protein may play a role in the tumor necrosis factor-alpha and MAP kinase signaling pathways. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Description

Muscle RAS oncogene homolog

Tissue specificity

Tissue enhanced (brain, heart muscle)

Subcell location

Vesicles, Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
RAS pathway related proteins

Chromosome

3 (138347648 - 138405534)

Ensembl ID

ENSG00000158186  (ver. 103.38)

Orthologs

Mouse Mras: ENSMUSG00000032470

UniProt

O14807

neXtProt

NX_O14807

Human splice variants
Mouse splice variants

Protein structure