SSTR5

Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene. [provided by RefSeq, Feb 2010]

Description

Somatostatin receptor 5

Tissue specificity

Group enriched (adrenal gland, heart muscle, pituitary gland)

Subcell location

Plasma membrane

Predicted location

Membrane

Protein family

FDA approved drug targets
G-protein coupled receptors
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins

Chromosome

16 (1078781 - 1080142)

Ensembl ID

ENSG00000162009  (ver. 103.38)

Orthologs

Mouse Sstr5: ENSMUSG00000050824

UniProt

P35346

neXtProt

NX_P35346

Human splice variants
Mouse splice variants

Protein structure