10-4121-25

antibody from ABEOMICS Inc.
Targeting: DDX58 DKFZp434J1111, FLJ13599, RIG-1, RIG-I, RIG1
Provider product page for 10-4121-25

Antibody data

Product number
10-4121-25 - Provider product page
Provider
ABEOMICS Inc.
Product name
Anti-RIG-I Antibody
Antibody type
Monoclonal
Description
RIG-I (retinoic-acid-inducible gene I), also known as DDX58 (DEAD (Asp-Glu-Ala-Asp) box polypeptide 58) is a 925-residue cytoplasmic viral RNA receptor, critically involved in the activation of the innate immune response to RNA virus infection. It is a member of the RIG-I-like receptor (RLR) family and is an essential intracellular sensor for several 5-triphosphorylated RNA viruses. RIG-I elicits its antiviral interferon (IFN) responses by recognizing viral double-stranded RNAs (dsRNAs). Structurally it comprises a helicase domain, a C-terminal domain, and N-terminal CARDs (caspase activation recruitment domains) involved in activating MAVS (mitochondrial antiviral signaling protein). Upon binding of 5?-triphosphorylated RNA, RIG-I undergoes conformational changes and post-translational modifications that allow multimerization and interaction with the mitochondrial antiviral signaling protein (MAVS).
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Antigen sequence
A partial length recombinant human
RIG-I protein (amino acids 1-220) w
as used as the immunogen for this a
ntibody.
Isotype
IgG
Antibody clone number
ABM4H29
Vial size
100 µg
Concentration
0.5 mg/ml
Storage
Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeat freez thawing
DDX58 protein structure - 10-4121-25 shown in red.