KCNMB2

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which decreases the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants of this gene. Additional variants are discussed in the literature, but their full length nature has not been described. [provided by RefSeq, Jul 2013]

Description

Potassium calcium-activated channel subfamily M regulatory beta subunit 2

Tissue specificity

Tissue enhanced (epididymis, fallopian tube, ovary)

Predicted location

Membrane

Protein family

FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters

Chromosome

3 (178272932 - 178844429)

Ensembl ID

ENSG00000197584  (ver. 103.38)

Orthologs

-

UniProt

Q9Y691

neXtProt

NX_Q9Y691

Human splice variants

Protein structure