SCN3A

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

Sodium voltage-gated channel alpha subunit 3

Tissue specificity

Group enriched (brain, lymphoid tissue)

Predicted location

Membrane

Protein family

Disease related genes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Voltage-gated ion channels

Chromosome

2 (165087526 - 165204050)

Ensembl ID

ENSG00000153253  (ver. 103.38)

Orthologs

Mouse Scn3a: ENSMUSG00000057182

UniProt

Q9NY46

neXtProt

NX_Q9NY46

Human splice variants
Mouse splice variants

Protein structure