BS6794

antibody from Bioworld Technology, Inc
Targeting: PTPN22 Lyp, Lyp1, Lyp2, PTPN8
Provider product page for BS6794
Western blot
Immunohistochemistry

Antibody data

Product number
BS6794 - Provider product page
Provider
Bioworld Technology, Inc
Product name
PTPN22 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human PTPN22.
Description
The protein tyrosine phosphatase PTPN22 (PTP22, LYP, PEP, formerly PTPN8) is a genetic variant that confers risk of developing diverse human autoimmune diseases such as type 1 diabetes and rheumatoid arthritis. The minor allele of a missense SNP in PTPN22 encodes a hematopoietic-specific protein tyrosine phosphatase also known as ¡ùLyp.¡ì The risk allele is present in about 17% of Caucasian individuals from the general population and in approximately 28% of Caucasian individuals with rheumatoid arthritis; it is thought to disrupt the P1 proline-rich motif that is important for interaction with the Src homology-3 (SH3) domain of CSK (cytoplasmic tyrosine kinase), potentially altering the normal functions of these proteins as negative regulators of T cell activation. The interaction between CSK and PTPN22 is highly specific and it is speculated that PTPN22 may be an effector and/or regulator of CSK in T cells and other hematopoietic cells.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
PTPN22 protein structure - BS6794 shown in red.