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PTPN22
Protein tyrosine phosphatase non-receptor type 22Lyp, Lyp1, Lyp2, PTPN8
This gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Mar 2009]
Top validated antibodies |
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| Proteintech Group |  11783-1-AP |
4 references | Polyclonal |
WB
EL
IP
IHC
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| Novus Biologicals | NBP2-69989 |
Polyclonal |
WB
EL
ICC
IHC
FC
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| Invitrogen Antibodies | 11783-1-AP |
Polyclonal |
WB
IP
IHC
OA
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| R&D Systems | AF3428 |
2 references | Polyclonal |
WB
ICC
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| NovoPro Bioscience Inc. | 114319 |
Polyclonal |
WB
EL
IP
IHC
|
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