Explore
Validate
Learn
Other assayAntibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Other assay [1]
Submit
Validation data
Reference
Comment
Report error
- Product number
- MA1-70057 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Complement Factor H Monoclonal Antibody (OX-24)
- Antibody type
- Monoclonal
- Antigen
- Other
- Description
- MA1-70057 detects Complement Factor H in human samples.
- Antibody clone number
- OX-24
- Concentration
- 1 mg/mL
Submitted references Complement Genetic Variants and FH Desialylation in S. pneumoniae-Haemolytic Uraemic Syndrome.
Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.
Gómez Delgado I, Corvillo F, Nozal P, Arjona E, Madrid Á, Melgosa M, Bravo J, Szilágyi Á, Csuka D, Veszeli N, Prohászka Z, Sánchez-Corral P
Frontiers in immunology 2021;12:641656
Frontiers in immunology 2021;12:641656
Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage.
Malik TH, Gitterman DP, Lavin DP, Lomax-Browne HJ, Hiemeyer EC, Moran LB, Boroviak K, Cook HT, Gilmore AC, Mandwie M, Ahmad A, Alexander IE, Logan GJ, Marchbank KJ, Bradley A, Pickering MC
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 30;118(13)
Proceedings of the National Academy of Sciences of the United States of America 2021 Mar 30;118(13)
No comments: Submit comment
Supportive validation
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Fig. 4. HDM-FH ameliorates glomerular C3 in hFH-FHR5mut mice. ( A ) Representative glomerular images and ( B ) staining scores for C3b/iC3b/C3c, C3d, FHR5mut, FH, IgG, and properdin in male hFH-FHR5mut mice treated with either AAV-GFP ( n = 5, black dots) or AAV-HDM-FH ( n = 7). Bars denote the median, and whiskers denote the interquartile range. * P = 0.0013, derived from Mann-Whitney U test. Plasma hFH/HDM-FH ( C ), C3 ( D ), and FHR5mut ( E ) levels after administration of either AAV-GFP or AAV-HDM-FH to hFH-FHR5mut male mice. Bars denote the mean, and whiskers denote the SD. P values are derived from two-way ANOVA with Bonferroni multiple comparisons test.
