BS4108

antibody from Bioworld Technology, Inc

Targeting: JAK1 JAK1A, JAK1B, JTK3

Immunohistochemistry

Antibody data

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Validation data

Product number: BS4108 - Provider product page
Provider: Bioworld Technology, Inc
Proper citation: Bioworld Technology Cat#BS4108, RRID:AB_1662701
Product name: JAK1 (phospho Y1022) polyclonal antibody
Antibody type: Polyclonal
Antigen: Synthetic phosphopeptide derived from human JAK1 around the phosphorylation site of Tyrosine 1022.
Description: JAK1 (Janus kinase 1) belongs to the family of non-receptor Janus tyrosine kinases, which regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Immunological stimuli, such as interferons and cytokines, induce recruitment of Stat transcription factors to cytokine receptor-associated JAK1. JAK1 then phosphorylates proximal Stat factors, which subsequently dimerize, translocate to the nucleus and bind to cis elements upstream of target gene promoters to regulate transcription. Upon ligand binding, JAK1 undergoes tyrosine phosphorylation and catalytic activation in an interdependent manner. Phosphorylation of tyrosine residues at positions 1022 and 1023 is believed to function in the activation of catalytic events.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Isotype: IgG
Vial size: 100ul
Concentration: 1 mg/ml
Storage: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

JAK1 protein structure - BS4108 shown in red.