JAK1

gene product
JAK1A, JAK1B, JTK3
Janus kinase 1 (JAK1), is a member of a new class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The second phosphotransferase domain bears all the hallmarks of a protein kinase, although its structure differs significantly from that of the PTK and threonine/serine kinase family members. JAK1 is a large, widely expressed membrane-associated phosphoprotein. JAK1 is involved in the interferon-alpha/beta and -gamma signal transduction pathways. The reciprocal interdependence between JAK1 and TYK2 activities in the interferon-alpha pathway, and between JAK1 and JAK2 in the interferon-gamma pathway, may reflect a requirement for these kinases in the correct assembly of interferon receptor complexes. These kinases couple cytokine ligand binding to tyrosine phosphorylation of various known signaling proteins and of a unique family of transcription factors termed the signal transducers and activators of transcription, or STATs. [provided by RefSeq, Jul 2008]
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528 antibodies from 35 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
antibodies-online
205 antibodies
Novus Biologicals
13 antibodies
R&D Systems
10 antibodies
Invitrogen Antibodies
7 antibodies
Biorbyt
24 antibodies
GeneTex
7 antibodies
NSJ Bioreagents
7 antibodies
Signalway Antibody LLC
2 antibodies
Cell Signaling Technology, Inc
6 antibodies
Aviva Systems Biology
7 antibodies
St John's Laboratory
12 antibodies
Affinity Biosciences
4 antibodies
Acris Antibodies GmbH
11 antibodies
OriGene
16 antibodies
Abnova Corporation
6 antibodies
Arigo
3 antibodies
Boster Biological Technology
3 antibodies
Bioworld Technology, Inc
2 antibodies
NovoPro Bioscience Inc.
4 antibodies
ProSci
2 antibodies
Abbkine Scientific Co.Ltd.
5 antibodies
United States Biological
103 antibodies
MyBioSource
14 antibodies
Creative Biolabs
6 antibodies
Abgent
3 antibodies
FabGennix
3 antibodies
EMD Millipore
7 antibodies
Creative Diagnostics
3 antibodies
RabMAbs
2 antibodies
Abiocode, Inc.
1 antibody
LifeSpan BioSciences, Inc.
2 antibodies
Sigma-Aldrich
2 antibodies
Exalpha Biologicals, Inc.
1 antibody
GenWay
1 antibody