Tissue expression
Cell line expression

JAK1

gene product
JAK1A, JAK1B, JTK3 
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]
More gene data

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646 antibodies from 43 providers.

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AntibodyRefsTypeWBELICCIPIHCFC
Invitrogen Antibodies
27 antibodies
antibodies-online
205 antibodies
R&D Systems
10 antibodies
Novus Biologicals
14 antibodies
Proteintech Group
2 antibodies
GeneTex
7 antibodies
St John's Laboratory
18 antibodies
Affinity Biosciences
4 antibodies
OriGene
17 antibodies
Boster Biological Technology
6 antibodies
Biorbyt
37 antibodies
NSJ Bioreagents
7 antibodies
Signalway Antibody LLC
2 antibodies
Cell Signaling Technology, Inc
7 antibodies
Cusabio Biotech Co., Ltd
9 antibodies
Aviva Systems Biology
7 antibodies
Acris Antibodies GmbH
11 antibodies
Abnova Corporation
6 antibodies
Wuhan Fine Biotech Co., Ltd.
2 antibodies
HUABIO Research
1 antibody
Arigo
3 antibodies
Bioworld Technology, Inc
2 antibodies
NovoPro Bioscience Inc.
4 antibodies
ProSci
2 antibodies
Abbkine Scientific Co.Ltd.
5 antibodies
United States Biological
103 antibodies
MyBioSource
14 antibodies
Abgent
3 antibodies
Abbexa
15 antibodies
MilliporeSigma / Merck KGaA
7 antibodies
Miltenyi Biotec
4 antibodies
FabGennix
3 antibodies
EMD Millipore
7 antibodies
Creative Biolabs
34 antibodies
Creative Diagnostics
3 antibodies
RabMAbs
2 antibodies
Abiocode, Inc.
1 antibody
LifeSpan BioSciences, Inc.
2 antibodies
Leading Biology
2 antibodies
Exalpha Biologicals, Inc.
1 antibody
GenWay
1 antibody
CPTAC
1 antibody