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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [111]
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- Product number
- 66466-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- JAK1 antibody
- Antibody type
- Monoclonal
- Description
- JAK1 antibody (Cat. #66466-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, rat, mouse and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 3H7A8
- Vial size
- 20ul, 150ul
Submitted references Adipose-derived stem cell-conditioned medium mitigates ischemia-induced neuronal injury via the JAK1/STAT3 signaling pathway.
Apigenin ameliorates postoperative inflammation and accelerates wound healing in a rat model of perianal abscess by targeting the JAK1/STAT3 pathway in macrophages.
Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.
IL-22/IL-22R signaling attenuates mitochondrial damage in PCOS by modulating granulosa cell lipid metabolism through ETS1.
Xylazine-Adulterated Fentanyl-Induced Brain Toxicity: Mechanism Elucidation via Network Toxicology and Molecular Docking Approaches.
The USP1-WDR48 deubiquitinase complex functions as a molecular switch regulating tumor-associated macrophage activation and anti-tumor response.
Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.
UBE2T promotes papillary thyroid carcinoma progression by activating the JAK/STAT3 pathway via negative regulation of SOCS2.
Withaferin A ameliorates psoriasis-like skin lesions by suppressing oxidative stress in keratinocytes.
Luteolin ameliorates steroid-induced osteonecrosis of the femoral head via a gut microbiota-L-Carnitine-IFIH1 axis.
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Type I Interferons Induce CD8(+) T Cell Chemotaxis Through Regulating Melanocyte but Not Keratinocyte CXCL9/10/11 Secretion in the Initiation of Vitiligo.
Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling.
Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis.
Ailanthone inhibits bladder cancer tumor and cell proliferation, epithelial-mesenchymal transition, and activation of the Janus kinase/signal transducer and activator of transcription 3 signaling pathway.
Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway.
Modified Sijunzi Decoction Inhibits Pancreatic Cancer Progression and Improves Immune Suppression: Network Pharmacology and Experimental Validation.
Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats.
Ginsenoside Rk3 Alleviates Neuroinflammation and Gastrointestinal Dysfunction in Parkinson's Disease via Modulation of Gut Microbiota-Mediated Butyric Acid Metabolism.
New 1,2,3-triazole-linked (±)-agrimonolide derivatives as anti-ulcerative colitis agents inhibiting JAK1/STAT3 pathways.
Effects on Oral Squamous Carcinoma Cell Lines and Their Mechanisms of Pyrazole N-Aryl Sulfonate: A Novel Class of Selective Cyclooxygenase-2 Inhibitors.
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer.
Protocatechuic aldehyde inactivates STAT3 through disrupting the STAT3-JAK1 interaction in epidermal keratinocyte and improves atopic dermatitis-like skin inflammation.
Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress.
Fedratinib inhibits ovarian cancer progression by downregulating QPCT expression.
Myricetin alleviates DNCB-induced atopic dermatitis by modulating macrophage M1/M2 polarization.
Empagliflozin alleviates hepatic ischemia-reperfusion injury by inhibiting c-Myc through the JAK1-STAT3 signaling pathway.
Senkyunolide I alleviates allergic rhinitis by inhibiting JAK1/3-STAT3/6 and JNK signalings.
Xiaoqinglong decoction combined with Yupingfeng powder alleviates combined allergic rhinitis and asthma syndrome by regulating the JAK2-STAT1-MHC II signaling pathway to suppress B lymphocyte activation.
Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes.
Sleep deprivation-induced sympathetic activation promotes pro-tumoral macrophage phenotype via the ADRB2/KLF4 pathway to facilitate NSCLC metastasis.
Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer.
Inhibition of liver cancer cell growth by metabolites S-adenosylmethionine and nicotinic acid originating from liver progenitor cells.
Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms.
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
Dual-Action Tocilizumab-Conjugated Cisplatin Nanoparticles Overcome Chemoresistance and Metastasis in Non-Small-Cell Lung Cancer.
Exploring the anti-inflammatory mechanism of geniposide in rheumatoid arthritis via network pharmacology and experimental validation.
ADRB2 is regulated by TRIM22 and facilitates lung adenocarcinoma progression via JAK2/STAT3 signaling pathway.
MC-LR induces and exacerbates Colitis in mice through the JAK1/STAT3 pathway.
Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway.
CTSL Promotes Autophagy in Laryngeal Cancer Through the IL6-JAK-STAT3 Signalling Pathway.
Viral IL-10 can promote the proliferation, migration and invasion of nasopharyngeal carcinoma cells and inhibit their apoptosis.
Taurine Attenuates M1 Macrophage Polarization and IL-1β Production by Suppressing the JAK1/2-STAT1 Pathway via Metabolic Reprogramming.
Integrative multi-omics analysis proposes a metabolic classification of gliomas: distinct metabolic states, immune infiltration, and prognosis.
Oncostatin M mediates the causal relationship between obesity and chronic kidney disease: evidence from Mendelian randomization and experimental validation.
Dimethyl itaconate suppresses dendritic cell and CD8(+) T cell responses to halt vitiligo.
Exosomal Biglycan promotes gastric cancer progression via M2 polarization and CXCL10-mediated JAK/STAT1 activation.
Systems Network Integration of Transcriptomic, Proteomic, and Bioinformatic Analyses Reveals the Mechanism of XuanYunNing Tablets in Meniere's Disease via JAK-STAT Pathway Modulation.
Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model.
Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.
SIX4 Activation in Inflammatory Response Drives the Transformation of Colorectal Epithelium into Inflammation and Tumor via Feedback-Enhancing Inflammatory Signaling to Induce Tumor Stemness Signaling.
Pan-cancer single cell and spatial transcriptomics analysis deciphers the molecular landscapes of senescence related cancer-associated fibroblasts and reveals its predictive value in neuroblastoma via integrated multi-omics analysis and machine learning.
Schizonepeta tenuifolia Briq-Saposhnikovia divaricata decoction alleviates atopic dermatitis via downregulating macrophage TRPV1.
Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells.
Effectiveness of tofacitinib monotherapy for patients with IgG4-RD or idiopathic retroperitoneal fibrosis.
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
IGFBP7 regulates cell proliferation and migration through JAK/STAT pathway in gastric cancer and is regulated by DNA and RNA methylation.
pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection.
Vanillic Acid Protects PC12 Cells from Corticosterone-Induced Neurotoxicity via Regulating Immune and Metabolic Dysregulation Based on Computational Metabolomics.
High-throughput screening-based design of multifunctional natural polyphenol nano-vesicles to accelerate diabetic wound healing.
RNA-binding motif protein 28 enhances angiogenesis by improving STAT3 translation in hepatocellular carcinoma.
Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects.
Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3.
Xianling Lianxia formula enhances the inhibitory effects of trastuzumab on HER2-positive breast cancer.
Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics.
Interleukin-22 receptor 1-mediated stimulation of T-type Ca(2+) channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway.
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma.
Stromal-derived MAOB promotes prostate cancer growth and progression.
Investigation of cuproptosis regulator-mediated modification patterns and SLC30A7 function in GBM.
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling.
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Alizarin attenuates oxidative stress-induced mitochondrial damage in vascular dementia rats by promoting TRPM2 ubiquitination and proteasomal degradation via Smurf2.
Demethylzeylasteral alleviates inflammation and colitis via dual suppression of NF-κB and STAT3/5 by targeting IKKα/β and JAK2.
SENP6 restricts the IFN-I-induced signaling pathway and antiviral activity by deSUMOylating USP8.
Graveoline attenuates D-GalN/LPS-induced acute liver injury via inhibition of JAK1/STAT3 signaling pathway.
LIF Inhibits Proliferation of Esophageal Squamous Carcinoma Cells by Radiation Mediated Through JAK-STAT Signaling Pathway.
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism.
LncRNA MIR4435-2HG suppression regulates macrophage M1/M2 polarization and reduces intestinal inflammation in mice with ulcerative colitis.
Ulinastatin inhibits the metastasis of nasopharyngeal carcinoma by involving uPA/uPAR signaling.
Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization.
P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy.
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation.
IFN-γ enhances CLL cell resistance to ABT-199 by regulating MCL-1 and BCL-2 expression via the JAK-STAT3 signaling pathway.
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway.
The Protective Role of Scorias spongiosa Polysaccharide-Based Microcapsules on Intestinal Barrier Integrity in DSS-Induced Colitis in Mice.
GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.
IFNγ induces Bcl3 expression by JAK1/STAT1/p65 signaling, resulting in increased IL-8 expression in ovarian cancer cells.
Fibroblast Upregulation of Vitamin D Receptor Represents a Self-Protective Response to Limit Fibroblast Proliferation and Activation during Pulmonary Fibrosis.
EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1.
IFNγ-induced PD-L1 expression in ovarian cancer cells is regulated by JAK1, STAT1 and IRF1 signaling.
Periplaneta americana Extract Pretreatment Alleviates Oxidative Stress and Inflammation and Increases the Abundance of Gut Akkermansia muciniphila in Diquat-Induced Mice.
IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4.
Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2.
Study on the Molecular Basis of Huanglian Jiedu Decoction Against Atopic Dermatitis Integrating Chemistry, Biochemistry, and Metabolomics Strategies.
The Anti-Inflammatory and Anti-Pruritus Mechanisms of Huanglian Jiedu Decoction in the Treatment of Atopic Dermatitis.
CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways.
Polygalaxanthone III downregulates inflammation in the lipopolysaccharide-stimulated RAW264.7 macrophages: A quantibody array analysis.
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
Triptolide reduces salivary gland damage in a non-obese diabetic mice model of Sjögren's syndrome via JAK/STAT and NF-κB signaling pathways.
Increased expression of IFN-γ in preeclampsia impairs human trophoblast invasion via a SOCS1/JAK/STAT1 feedback loop.
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8).
Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.
CEP55 Promotes Cell Motility via JAK2⁻STAT3⁻MMPs Cascade in Hepatocellular Carcinoma.
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.
Huang H, Zheng M, Lai Y, Zhang Y, Chen Y, Liu N
Frontiers in cellular neuroscience 2026;20:1744887
Frontiers in cellular neuroscience 2026;20:1744887
Apigenin ameliorates postoperative inflammation and accelerates wound healing in a rat model of perianal abscess by targeting the JAK1/STAT3 pathway in macrophages.
Dai R, Cao L, Ren J, Liu J, Zhu K, Chen P, Yao W, Zhao X, Bao B, Zhang L
Frontiers in immunology 2026;17:1726917
Frontiers in immunology 2026;17:1726917
Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.
Beilina A, Park JH, Landeck N, Chia R, Ding J, Reed X, Bailey H, Kim C, Kaganovich A, Acri DJ, Brooks J, Mann A, Zaghloul KA, Marsan E, Raphael Gibbs J, DeCasien A, Cookson MR
Molecular neurodegeneration 2026 Mar 18;21(1)
Molecular neurodegeneration 2026 Mar 18;21(1)
IL-22/IL-22R signaling attenuates mitochondrial damage in PCOS by modulating granulosa cell lipid metabolism through ETS1.
Luo M, Chen Y, Chen H, Wen Y
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Mar 17;75(1)
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Mar 17;75(1)
Xylazine-Adulterated Fentanyl-Induced Brain Toxicity: Mechanism Elucidation via Network Toxicology and Molecular Docking Approaches.
Wang N, Ou Y, Wang Y, Huang Z, Hu Y, Zhao S
Journal of applied toxicology : JAT 2026 Jan;46(1):354-361
Journal of applied toxicology : JAT 2026 Jan;46(1):354-361
The USP1-WDR48 deubiquitinase complex functions as a molecular switch regulating tumor-associated macrophage activation and anti-tumor response.
Han D, Wang L, Jiang S, Su P, Chen B, Zhao W, Chen T, Zhang N, Wang X, Liang Y, Li Y, Li C, Chen X, Luo D, Yang Q
Cell death and differentiation 2026 Jan;33(1):92-110
Cell death and differentiation 2026 Jan;33(1):92-110
Inflammatory signaling differentially changes chromatin accessibility and gene expression of the PD- associated kinase LRRK2 between human and mice.
Beilina A, Park JH, Landeck N, Chia R, Ding J, Reed X, Bailey H, Kim C, Kaganovich A, Acri DJ, Brooks J, Mann A, Zaghloul KA, Marsan E, Gibbs JR, DeCasien A, Cookson MR
bioRxiv : the preprint server for biology 2026 Jan 12;
bioRxiv : the preprint server for biology 2026 Jan 12;
UBE2T promotes papillary thyroid carcinoma progression by activating the JAK/STAT3 pathway via negative regulation of SOCS2.
Zhang L, Li C, Zhou J, Zhang X, Fang H, Cai J, Tong H, Wen J, Zhang H, Shen M, Si Y
Seminars in oncology 2026 Feb;53(1):152439
Seminars in oncology 2026 Feb;53(1):152439
Withaferin A ameliorates psoriasis-like skin lesions by suppressing oxidative stress in keratinocytes.
Zhang MY, Liu YC, Liu XY, Chen DW, Han C, Shen X, Ding YX, Wang XP, Shi AP
Journal of Asian natural products research 2026 Feb;28(2):310-322
Journal of Asian natural products research 2026 Feb;28(2):310-322
Luteolin ameliorates steroid-induced osteonecrosis of the femoral head via a gut microbiota-L-Carnitine-IFIH1 axis.
Li T, Li Y, Gao J, Ma R, Peng Y, Zhang Q, Chen Y, Wang W
Journal of translational medicine 2026 Feb 6;24(1)
Journal of translational medicine 2026 Feb 6;24(1)
Targeting TFAM K76 acetylation attenuates mitochondrial dysfunction and kidney injury in diabetic kidney disease.
Fu T, Sun S, Wang Z, Zhao F, Zhen J, Ji X, Xue F, Mu Q, Wang Y, Liu Y, Wan Q
Cardiovascular diabetology 2026 Feb 3;25(1)
Cardiovascular diabetology 2026 Feb 3;25(1)
Type I Interferons Induce CD8(+) T Cell Chemotaxis Through Regulating Melanocyte but Not Keratinocyte CXCL9/10/11 Secretion in the Initiation of Vitiligo.
Wang D, Yang L, Zhang Y, Zhang H, Yang L, Chen L, Katayama I, Li Y, Chen K, Wu H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71575
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Feb 28;40(4):e71575
Revealing an unconventional JAK1/2-STAT3 branch in macrophage IFN-γ signaling.
Botman M, Huisman JMA, Drakaki A, Maas SL, Witalisz-Siepracka A, Stoiber D, van der Vorst EPC, Siebeler R, Hoeksema MA
Cell reports 2026 Feb 24;45(2):116985
Cell reports 2026 Feb 24;45(2):116985
Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1-Mediated M1 Macrophage Polarization in Sarcoidosis.
Liu M, Han Y, Xie B, Zhu L, Xu W, Han Y, Liao Y, Gao S, Jiang D, Geng J, Li Z, Hu Y, Dai H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e20635
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr 3;:e20635
Ailanthone inhibits bladder cancer tumor and cell proliferation, epithelial-mesenchymal transition, and activation of the Janus kinase/signal transducer and activator of transcription 3 signaling pathway.
Li J, Lv Y, Xue S, Li W, Zhang X
CytoJournal 2025;22:16
CytoJournal 2025;22:16
Kupffer Cell-derived IL6 Promotes Hepatocellular Carcinoma Metastasis Via the JAK1-ACAP4 Pathway.
Li T, Song X, Chen J, Li Y, Lin J, Li P, Yu S, Durojaye OA, Yang F, Liu X, Li J, Cheng S, Yao X, Ding X
International journal of biological sciences 2025;21(1):285-305
International journal of biological sciences 2025;21(1):285-305
Modified Sijunzi Decoction Inhibits Pancreatic Cancer Progression and Improves Immune Suppression: Network Pharmacology and Experimental Validation.
Zhang Y, Ruan L, Li X, Si W, Yang P, Ba H, Chen Z
Drug design, development and therapy 2025;19:8949-8966
Drug design, development and therapy 2025;19:8949-8966
Fecal Microbiota Transplantation Modulates Th17/Treg Balance via JAK/STAT Pathway in ARDS Rats.
Zhang D, Dong B, Chen J, Zhang Z, Zeng W, Liao L, Xiong X, Qin X, Fan X
Advanced biology 2025 Sep;9(9):e00028
Advanced biology 2025 Sep;9(9):e00028
Ginsenoside Rk3 Alleviates Neuroinflammation and Gastrointestinal Dysfunction in Parkinson's Disease via Modulation of Gut Microbiota-Mediated Butyric Acid Metabolism.
Zhou S, Liu Y, Liu Y, Duan Z, Zhu C, Wang P, Fu R
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24139-24154
Journal of agricultural and food chemistry 2025 Sep 24;73(38):24139-24154
New 1,2,3-triazole-linked (±)-agrimonolide derivatives as anti-ulcerative colitis agents inhibiting JAK1/STAT3 pathways.
Zhang X, Ju MQ, Yang HL, Zhang CF, Huang MK, Li YP, Wan CP, Mao ZW
Molecular diversity 2025 Sep 23;
Molecular diversity 2025 Sep 23;
Effects on Oral Squamous Carcinoma Cell Lines and Their Mechanisms of Pyrazole N-Aryl Sulfonate: A Novel Class of Selective Cyclooxygenase-2 Inhibitors.
Wang S, Shi M, Wang H, Zeng X, Zhang D, Zhang Z, Xu Z, Li Y
International journal of molecular sciences 2025 Sep 12;26(18)
International journal of molecular sciences 2025 Sep 12;26(18)
Porcine GWAS identifies ACOT11 as regulator for macrophage IL-1β maturation via IFNGR2 palmitoylation.
Zhang M, Liu S, Wu Z, Wang C, Zhang H, Yang J, Guo C, Dai M, Wang X, Ren W
Science China. Life sciences 2025 Oct;68(10):3037-3050
Science China. Life sciences 2025 Oct;68(10):3037-3050
Celastrol inhibits the DPYSL2-JAK/STAT pathway by targeting mito-IDHs mediated mitochondrial metabolism to exhaust breast cancer.
Shi QL, Feng CR, Li HY, Wang PL, Chen P, Wei X, Kuang WH, Li GJ, Qin SJ, Liu R, Chen RX, Zhang JZ, Song P, Yuan Y, Wang JG, Huang L
Acta pharmacologica Sinica 2025 Oct;46(10):2765-2778
Acta pharmacologica Sinica 2025 Oct;46(10):2765-2778
Protocatechuic aldehyde inactivates STAT3 through disrupting the STAT3-JAK1 interaction in epidermal keratinocyte and improves atopic dermatitis-like skin inflammation.
Yang X, Zhou Q, Liang L, Kang L, Yang J, Li X, Li F, Deng Y
International immunopharmacology 2025 Oct 30;164:115403
International immunopharmacology 2025 Oct 30;164:115403
Protective Effect of Mesaconate on Autoimmune Hepatitis via Suppression of Inflammatory Response and Oxidative Stress.
Zhang Q, Wang J, He Y, Zhang K, Hong W, Han T
Journal of clinical and translational hepatology 2025 Oct 28;13(10):847-856
Journal of clinical and translational hepatology 2025 Oct 28;13(10):847-856
Fedratinib inhibits ovarian cancer progression by downregulating QPCT expression.
Dong Y, Deng Y, Zhu L, Li R, Yang H, Yang L
Discover oncology 2025 Oct 14;16(1):1865
Discover oncology 2025 Oct 14;16(1):1865
Myricetin alleviates DNCB-induced atopic dermatitis by modulating macrophage M1/M2 polarization.
Zhang X, Li J, Liu Y, Ma R, Li C, Xu Z, Wang R, Zhang L, Zhang Y
International immunopharmacology 2025 Oct 10;163:115212
International immunopharmacology 2025 Oct 10;163:115212
Empagliflozin alleviates hepatic ischemia-reperfusion injury by inhibiting c-Myc through the JAK1-STAT3 signaling pathway.
Tulahong A, Xu X, Zhou T, Ruze R, Yuan Z, Qiao P, Jiang T, Aji T, Shao Y
International immunopharmacology 2025 Nov 14;165:115508
International immunopharmacology 2025 Nov 14;165:115508
Senkyunolide I alleviates allergic rhinitis by inhibiting JAK1/3-STAT3/6 and JNK signalings.
Liu T, Wen T, Shen X, Xie C, Zhang R, Tian L
International immunopharmacology 2025 Nov 14;165:115462
International immunopharmacology 2025 Nov 14;165:115462
Xiaoqinglong decoction combined with Yupingfeng powder alleviates combined allergic rhinitis and asthma syndrome by regulating the JAK2-STAT1-MHC II signaling pathway to suppress B lymphocyte activation.
Wang R, Xiao Z, Shi X, Ye F, Chen J, Dong M, Qiu H, Zhang Y, Shi J, Zhou M, Yang Q
Journal of ethnopharmacology 2025 May 28;348:119789
Journal of ethnopharmacology 2025 May 28;348:119789
Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes.
Tian C, Sun L, Liu K, Fu L, Zhang Y, Chen W, He F, Yang J
Nature communications 2025 May 26;16(1):4863
Nature communications 2025 May 26;16(1):4863
Sleep deprivation-induced sympathetic activation promotes pro-tumoral macrophage phenotype via the ADRB2/KLF4 pathway to facilitate NSCLC metastasis.
Yin S, Wang J, Jia Y, Wang X, Zhao Y, Liu T, Lv W, Duan Y, Zhao S, Wang S, Liu L
iScience 2025 May 16;28(5):112321
iScience 2025 May 16;28(5):112321
Interleukin-7 enhances recruitment of MDSCs by regulating MCP-1 via JAK1/STAT3 signaling pathway in non-small cell lung cancer.
Cheng H, Shao Y, Zhang A, Li C, Li X, Fu Y, Ming J
Scientific reports 2025 May 15;15(1):16869
Scientific reports 2025 May 15;15(1):16869
Inhibition of liver cancer cell growth by metabolites S-adenosylmethionine and nicotinic acid originating from liver progenitor cells.
Liu WM, Chen CY, Ma HQ, Zhang QQ, Zhou X, Wu YL, Huang WJ, Qi XS, Zhang YX, Tang D, Sun HY, Wu HP, Jiao YF, He ZY, Yu WF, Yan HX
Journal of gastroenterology 2025 Jun;60(6):754-769
Journal of gastroenterology 2025 Jun;60(6):754-769
Discovery of a Proteolysis-Targeting Chimera Degrader of JAK2 as a Potential Therapeutic Agent for JAK2-Mediated Myeloproliferative Neoplasms.
Wang C, Chen Z, Wang S, Wang J, Yu P, Huang C, Wu Y, Zhao Z, Mei W, Li H, Zhu L
Journal of medicinal chemistry 2025 Jun 12;68(11):12085-12099
Journal of medicinal chemistry 2025 Jun 12;68(11):12085-12099
African swine fever virus MGF505-4R facilitates cGAS degradation through TOLLIP-mediated selective autophagy and inhibits the formation of ISGF3 to evade innate immunity.
Yao M, Li P, Li X, Li W, Qian P
Veterinary research 2025 Jul 5;56(1):137
Veterinary research 2025 Jul 5;56(1):137
Dual-Action Tocilizumab-Conjugated Cisplatin Nanoparticles Overcome Chemoresistance and Metastasis in Non-Small-Cell Lung Cancer.
Wang Y, Wu F, Yang T, Li B, Wang H, Ye P, Li W
Pharmaceutics 2025 Jul 21;17(7)
Pharmaceutics 2025 Jul 21;17(7)
Exploring the anti-inflammatory mechanism of geniposide in rheumatoid arthritis via network pharmacology and experimental validation.
Huang M, Jiang J, Li YJ, Jiang MY, Yang M, Deng H, Wu YG, Wu LJ, Leng X, Chen JL, Sun WK
Scientific reports 2025 Jul 10;15(1):24812
Scientific reports 2025 Jul 10;15(1):24812
ADRB2 is regulated by TRIM22 and facilitates lung adenocarcinoma progression via JAK2/STAT3 signaling pathway.
Xu M, Han S, Yang M, Chen J, Liu Y, Zhou Y, Shi J
Scientific reports 2025 Jul 1;15(1):22083
Scientific reports 2025 Jul 1;15(1):22083
MC-LR induces and exacerbates Colitis in mice through the JAK1/STAT3 pathway.
Zhou X, Yang Y, Yan C, Feng S, Zhan C
Journal of toxicology and environmental health. Part A 2025 Jan 26;:1-11
Journal of toxicology and environmental health. Part A 2025 Jan 26;:1-11
Suberosin attenuates rheumatoid arthritis by repolarizing macrophages and inhibiting synovitis via the JAK/STAT signaling pathway.
Liu H, Li Q, Chen Y, Dong M, Liu H, Zhang J, Yang L, Yin G, Xie Q
Arthritis research & therapy 2025 Jan 21;27(1):12
Arthritis research & therapy 2025 Jan 21;27(1):12
CTSL Promotes Autophagy in Laryngeal Cancer Through the IL6-JAK-STAT3 Signalling Pathway.
Wang X, Wang J, Wang L, Song M, Meng H, Guo E, Miao S
Journal of cellular and molecular medicine 2025 Feb;29(3):e70364
Journal of cellular and molecular medicine 2025 Feb;29(3):e70364
Viral IL-10 can promote the proliferation, migration and invasion of nasopharyngeal carcinoma cells and inhibit their apoptosis.
Qiu Q, Yang X, Li X, Ren Y, Huang N
Discover oncology 2025 Feb 18;16(1):199
Discover oncology 2025 Feb 18;16(1):199
Taurine Attenuates M1 Macrophage Polarization and IL-1β Production by Suppressing the JAK1/2-STAT1 Pathway via Metabolic Reprogramming.
Zhang Z, Li D, He S, Xu W, Lv Q, Wang Y, Xu J, Yu Z, Liu S, Ge Y, Shi F, Yan Y
Biology 2025 Dec 6;14(12)
Biology 2025 Dec 6;14(12)
Integrative multi-omics analysis proposes a metabolic classification of gliomas: distinct metabolic states, immune infiltration, and prognosis.
Zhu Q, Niu W, Mu M, Ye C, Niu C
Journal of translational medicine 2025 Dec 30;24(1):122
Journal of translational medicine 2025 Dec 30;24(1):122
Oncostatin M mediates the causal relationship between obesity and chronic kidney disease: evidence from Mendelian randomization and experimental validation.
Zhang X, Tian Y, Ren X, Liu J, Wang G
Diabetology & metabolic syndrome 2025 Dec 3;17(1):446
Diabetology & metabolic syndrome 2025 Dec 3;17(1):446
Dimethyl itaconate suppresses dendritic cell and CD8(+) T cell responses to halt vitiligo.
Wang Y, Chen Y, Ma J, Wu L, Kang P, Chen J, Du P, Wu W, Wang X, He K, Yang Y, Guo S, Guo W, Liu L, Jian Z, Gao T, Li S, Li C
BMC medicine 2025 Dec 29;23(1):698
BMC medicine 2025 Dec 29;23(1):698
Exosomal Biglycan promotes gastric cancer progression via M2 polarization and CXCL10-mediated JAK/STAT1 activation.
Li W, Wei H, Liu J, Zhao Z, Wang F, Qiao L, Yin S, Zhang C, Huo M
Cancer letters 2025 Aug 28;626:217758
Cancer letters 2025 Aug 28;626:217758
Systems Network Integration of Transcriptomic, Proteomic, and Bioinformatic Analyses Reveals the Mechanism of XuanYunNing Tablets in Meniere's Disease via JAK-STAT Pathway Modulation.
Jin Z, Wang C, Gao Y, Tao X, Wu C, Guo S, Huang J, Zhou J, Qiao C, Chai K, Chang H, Li C, Zou X, Wu J
Pharmaceuticals (Basel, Switzerland) 2025 Aug 25;18(9)
Pharmaceuticals (Basel, Switzerland) 2025 Aug 25;18(9)
Discovery of a Highly Potent and Selective Tyrosine Kinase 2 (TYK2) Degrader with In Vivo Therapeutic Efficacy in a Murine Psoriasis Model.
Xiong S, Yang J, Yang M, Xiao M, Ha S, Tao W, Ma L, Ji C, Xiang H, Luo G
Journal of medicinal chemistry 2025 Apr 10;68(7):7560-7578
Journal of medicinal chemistry 2025 Apr 10;68(7):7560-7578
Quercetin of huoxuehuayu tongluo decoction and azithromycin combination therapy effectively improves rat tubal factor infertility by inhibiting inflammation.
Shao L, Wang N, Yan Y, Tan Y, Wu Q, Lei L, Wang M, Liu L
Iranian journal of basic medical sciences 2024;27(6):685-694
Iranian journal of basic medical sciences 2024;27(6):685-694
SIX4 Activation in Inflammatory Response Drives the Transformation of Colorectal Epithelium into Inflammation and Tumor via Feedback-Enhancing Inflammatory Signaling to Induce Tumor Stemness Signaling.
Zhang Z, Huang H, Peng L, Zhou B, Yang H, Tang Z, Yan W, Chen W, Liu Z, Zheng D, Shen P, Fang W
International journal of biological sciences 2024;20(12):4618-4634
International journal of biological sciences 2024;20(12):4618-4634
Pan-cancer single cell and spatial transcriptomics analysis deciphers the molecular landscapes of senescence related cancer-associated fibroblasts and reveals its predictive value in neuroblastoma via integrated multi-omics analysis and machine learning.
Li S, Luo J, Liu J, He D
Frontiers in immunology 2024;15:1506256
Frontiers in immunology 2024;15:1506256
Schizonepeta tenuifolia Briq-Saposhnikovia divaricata decoction alleviates atopic dermatitis via downregulating macrophage TRPV1.
Li H, Liang J, Li P, Li X, Liu Q, Yang S, Zhang C, Liu S, He Y, Tan C
Frontiers in pharmacology 2024;15:1413513
Frontiers in pharmacology 2024;15:1413513
Exosomes derived from syncytia induced by SARS-2-S promote the proliferation and metastasis of hepatocellular carcinoma cells.
Li H, Lin H, Fan T, Huang L, Zhou L, Tian X, Zhao R, Zhang Y, Yang X, Wan L, Zhong H, Jiang N, Wei C, Chen W, Hou L
Frontiers in cellular and infection microbiology 2024;14:1415356
Frontiers in cellular and infection microbiology 2024;14:1415356
Effectiveness of tofacitinib monotherapy for patients with IgG4-RD or idiopathic retroperitoneal fibrosis.
Cao X, Li S, Wan J, Yu Z, Dong G, Zhou W
Clinical and experimental rheumatology 2024 Sep;42(9):1736-1743
Clinical and experimental rheumatology 2024 Sep;42(9):1736-1743
Nicorandil mitigates arsenic trioxide-induced lung injury via modulating vital signalling pathways SIRT1/PGC-1α/TFAM, JAK1/STAT3, and miRNA-132 expression.
Abdel-Wahab BA, Zafaar D, Habeeb MS, El-Shoura EAM
British journal of pharmacology 2024 Sep;181(17):3215-3231
British journal of pharmacology 2024 Sep;181(17):3215-3231
IGFBP7 regulates cell proliferation and migration through JAK/STAT pathway in gastric cancer and is regulated by DNA and RNA methylation.
Mo W, Deng L, Cheng Y, Ge S, Wang J
Journal of cellular and molecular medicine 2024 Oct;28(19):e70080
Journal of cellular and molecular medicine 2024 Oct;28(19):e70080
pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection.
Huang Z, Kong C, Zhang W, You J, Gao C, Yi J, Mai Z, Chen X, Zhou P, Gong L, Zhang G, Wang H
PLoS pathogens 2024 Oct;20(10):e1012613
PLoS pathogens 2024 Oct;20(10):e1012613
Vanillic Acid Protects PC12 Cells from Corticosterone-Induced Neurotoxicity via Regulating Immune and Metabolic Dysregulation Based on Computational Metabolomics.
Lv T, Xue D, Wang P, Gong W, Wang K
ACS omega 2024 Oct 1;9(39):40456-40467
ACS omega 2024 Oct 1;9(39):40456-40467
High-throughput screening-based design of multifunctional natural polyphenol nano-vesicles to accelerate diabetic wound healing.
Zhao X, Su S, Wu C, Deng Y, Chen Y, Yu T, Li C, Zhang Y, Wang X, Zhou Y, Zhang X
Journal of nanobiotechnology 2024 Nov 21;22(1):725
Journal of nanobiotechnology 2024 Nov 21;22(1):725
RNA-binding motif protein 28 enhances angiogenesis by improving STAT3 translation in hepatocellular carcinoma.
Han H, Yuan Y, Li C, Liu L, Yu H, Han G, Wang Q, Lin M, Huang J
Cancer letters 2024 Nov 1;604:217191
Cancer letters 2024 Nov 1;604:217191
Resveratrol-loaded sulfated Hericium erinaceus β-glucan-chitosan nanoparticles: Preparation, characterization and synergistic anti-inflammatory effects.
Zhang Z, Ge M, Wu D, Li W, Chen W, Liu P, Zhang H, Yang Y
Carbohydrate polymers 2024 May 15;332:121916
Carbohydrate polymers 2024 May 15;332:121916
Helicobacter pylori disrupts gastric mucosal homeostasis by stimulating macrophages to secrete CCL3.
Wei YF, Li X, Zhao MR, Liu S, Min L, Zhu ST, Zhang ST, Xie SA
Cell communication and signaling : CCS 2024 May 10;22(1):263
Cell communication and signaling : CCS 2024 May 10;22(1):263
Xianling Lianxia formula enhances the inhibitory effects of trastuzumab on HER2-positive breast cancer.
Li F, Wu Y, Shi Y, Liu X, Xie Y, Liu S
Acta biochimica et biophysica Sinica 2024 Mar 25;56(3):462-473
Acta biochimica et biophysica Sinica 2024 Mar 25;56(3):462-473
Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics.
Lu R, Hong J, Fu T, Zhu Y, Tong R, Ai D, Wang S, Huang Q, Chen C, Zhang Z, Zhang R, Guo H, Li B
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2308945
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(24):e2308945
Interleukin-22 receptor 1-mediated stimulation of T-type Ca(2+) channels enhances sensory neuronal excitability through the tyrosine-protein kinase Lyn-dependent PKA pathway.
Cai H, Chen S, Sun Y, Zheng T, Liu Y, Tao J, Zhang Y
Cell communication and signaling : CCS 2024 Jun 3;22(1):307
Cell communication and signaling : CCS 2024 Jun 3;22(1):307
Picroside II promotes HSC apoptosis and inhibits the cholestatic liver fibrosis in Mdr2(-/-) mice by polarizing M1 macrophages and balancing immune responses.
Jia K, Ma Z, Zhang Y, Xie K, Li J, Wu J, Qu J, Li F, Li X
Chinese journal of natural medicines 2024 Jul;22(7):582-598
Chinese journal of natural medicines 2024 Jul;22(7):582-598
Identification and Validation of a Prognostic Signature Derived from the Cancer Stem Cells for Oral Squamous Cell Carcinoma.
Shi M, Huang K, Wei J, Wang S, Yang W, Wang H, Li Y
International journal of molecular sciences 2024 Jan 14;25(2)
International journal of molecular sciences 2024 Jan 14;25(2)
Stromal-derived MAOB promotes prostate cancer growth and progression.
Pu T, Wang J, Wei J, Zeng A, Zhang J, Chen J, Yin L, Li J, Lin TP, Melamed J, Corey E, Gao AC, Wu BJ
Science advances 2024 Feb 9;10(6):eadi4935
Science advances 2024 Feb 9;10(6):eadi4935
Investigation of cuproptosis regulator-mediated modification patterns and SLC30A7 function in GBM.
Yu W, Gui S, Xie J, Peng L, Xiao J, Luo H, Tao Z, Cheng Z
Aging 2024 Feb 22;16(4):3554-3582
Aging 2024 Feb 22;16(4):3554-3582
Crosstalk between KDEL receptor and EGF receptor mediates cell proliferation and migration via STAT3 signaling.
Jia J, Zhu L, Yue X, Tang S, Jing S, Tan C, Du Y, Gao J, Lee I, Qian Y
Cell communication and signaling : CCS 2024 Feb 20;22(1):140
Cell communication and signaling : CCS 2024 Feb 20;22(1):140
Transcriptotype-Driven Discovery of Apigenin as a Therapy against Cholestatic Liver Fibrosis: Through Inhibition of PANoptosis and Following Type-I Interferon Responses.
Duan S, Li X, Han J, Yang Y, Luo R, Cai Y, Li X, Zheng Q, Guo J, Liu R
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Antioxidants (Basel, Switzerland) 2024 Feb 20;13(3)
Alizarin attenuates oxidative stress-induced mitochondrial damage in vascular dementia rats by promoting TRPM2 ubiquitination and proteasomal degradation via Smurf2.
Pan GP, Liu YH, Qi MX, Guo YQ, Shao ZL, Liu HT, Qian YW, Guo S, Yin YL, Li P
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156119
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156119
Demethylzeylasteral alleviates inflammation and colitis via dual suppression of NF-κB and STAT3/5 by targeting IKKα/β and JAK2.
Wen T, Liu T, Chen H, Liu Q, Shen X, Hu Q
International immunopharmacology 2024 Dec 5;142(Pt B):113260
International immunopharmacology 2024 Dec 5;142(Pt B):113260
SENP6 restricts the IFN-I-induced signaling pathway and antiviral activity by deSUMOylating USP8.
Guo J, Zheng H, Xiong S
Cellular & molecular immunology 2024 Aug;21(8):892-904
Cellular & molecular immunology 2024 Aug;21(8):892-904
Graveoline attenuates D-GalN/LPS-induced acute liver injury via inhibition of JAK1/STAT3 signaling pathway.
He J, Feng X, Liu Y, Wang Y, Ge C, Liu S, Jiang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117163
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117163
LIF Inhibits Proliferation of Esophageal Squamous Carcinoma Cells by Radiation Mediated Through JAK-STAT Signaling Pathway.
Luo H, Yang Z, Zhang Q, Li T, Liu R, Feng S, Liu Z, Sun S, Chen J, Wang X, Xie X
Journal of Cancer 2023;14(4):532-543
Journal of Cancer 2023;14(4):532-543
Small-molecule MHC-II inducers promote immune detection and anti-cancer immunity via editing cancer metabolism.
Huang L, Zhang J, Wei B, Chen S, Zhu S, Qi W, Pei X, Li L, Liu W, Wang Y, Xu X, Xie LG, Chen L
Cell chemical biology 2023 Sep 21;30(9):1076-1089.e11
Cell chemical biology 2023 Sep 21;30(9):1076-1089.e11
LncRNA MIR4435-2HG suppression regulates macrophage M1/M2 polarization and reduces intestinal inflammation in mice with ulcerative colitis.
Cao L, Tan Q, Zhu R, Ye L, Shi G, Yuan Z
Cytokine 2023 Oct;170:156338
Cytokine 2023 Oct;170:156338
Ulinastatin inhibits the metastasis of nasopharyngeal carcinoma by involving uPA/uPAR signaling.
Li CZ, Qiang YY, Liu ZJ, Zheng LS, Peng LX, Mei Y, Meng DF, Wei WW, Chen DW, Xu L, Lang YH, Xie P, Peng XS, Wang MD, Guo LL, Shu DT, Ding LY, Lin ST, Luo FF, Wang J, Li SS, Huang BJ, Chen JD, Qian CN
Drug development research 2023 Nov;84(7):1468-1481
Drug development research 2023 Nov;84(7):1468-1481
Macrophage autophagy deficiency-induced CEBPB accumulation alleviates atopic dermatitis via impairing M2 polarization.
Zhu Y, Liu Y, Ma Y, Chen L, Huang H, Huang S, Zhang H, He Y, Tan C, He Y, Qiang L
Cell reports 2023 Nov 28;42(11):113430
Cell reports 2023 Nov 28;42(11):113430
P53 Deficiency Accelerates Esophageal Epithelium Intestinal Metaplasia Malignancy.
Qiu Q, Guo G, Guo X, Hu X, Yu T, Liu G, Zhang H, Chen Y, She J
Biomedicines 2023 Mar 13;11(3)
Biomedicines 2023 Mar 13;11(3)
Ketogenic diet attenuates neuroinflammation and induces conversion of M1 microglia to M2 in an EAE model of multiple sclerosis by regulating the NF-κB/NLRP3 pathway and inhibiting HDAC3 and P2X7R activation.
Sun W, Wang Q, Zhang R, Zhang N
Food & function 2023 Jul 31;14(15):7247-7269
Food & function 2023 Jul 31;14(15):7247-7269
IFN-γ enhances CLL cell resistance to ABT-199 by regulating MCL-1 and BCL-2 expression via the JAK-STAT3 signaling pathway.
Shao X, Meng X, Yang H, Wang X, Qin L, Shen G, Xi X, Zhao H, Macip S, Chen Y
Leukemia & lymphoma 2023 Jan;64(1):71-78
Leukemia & lymphoma 2023 Jan;64(1):71-78
MicroRNA profiling reveals the role of miR-133b-3p in promoting apoptosis and inhibiting cell proliferation and testosterone synthesis in mouse TM3 cells.
Pan C, Fei Q, Jin J, Zheng J, Wu D, Li H, Huang X, Kong X
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
In vitro cellular & developmental biology. Animal 2023 Jan;59(1):63-75
Knockdown of Brg1 reduced mucus secretion in HDM stimulated airway inflammation.
Xu M, Hu J, Yang L, Gen G, Fu Z, Luo Z, Zou W
Molecular immunology 2023 Jan;153:42-50
Molecular immunology 2023 Jan;153:42-50
LINC00926 is involved in hypoxia-induced vascular endothelial cell dysfunction via miR-3194-5p regulating JAK1/STAT3 signaling pathway.
Jiang Y, Xu CH, Zhao Y, Ji YH, Wang XT, Liu Y
European journal of histochemistry : EJH 2023 Jan 16;67(1)
European journal of histochemistry : EJH 2023 Jan 16;67(1)
The Protective Role of Scorias spongiosa Polysaccharide-Based Microcapsules on Intestinal Barrier Integrity in DSS-Induced Colitis in Mice.
Xu Y, Feng H, Zhang Z, Zhang Q, Tang J, Zhou J, Wang Y, Peng W
Foods (Basel, Switzerland) 2023 Feb 3;12(3)
Foods (Basel, Switzerland) 2023 Feb 3;12(3)
GABA induced by sleep deprivation promotes the proliferation and migration of colon tumors through miR-223-3p endogenous pathway and exosome pathway.
Bao H, Peng Z, Cheng X, Jian C, Li X, Shi Y, Zhu W, Hu Y, Jiang M, Song J, Fang F, Chen J, Shu X
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344
Journal of experimental & clinical cancer research : CR 2023 Dec 18;42(1):344
IFNγ induces Bcl3 expression by JAK1/STAT1/p65 signaling, resulting in increased IL-8 expression in ovarian cancer cells.
Gaire B, Padmanabhan S, Zou Y, Uddin MM, Reddy SU, Vancurova I
FEBS open bio 2023 Aug;13(8):1495-1506
FEBS open bio 2023 Aug;13(8):1495-1506
Fibroblast Upregulation of Vitamin D Receptor Represents a Self-Protective Response to Limit Fibroblast Proliferation and Activation during Pulmonary Fibrosis.
Wei J, Zhan J, Ji H, Xu Y, Xu Q, Zhu X, Liu Y
Antioxidants (Basel, Switzerland) 2023 Aug 18;12(8)
Antioxidants (Basel, Switzerland) 2023 Aug 18;12(8)
EHBP1L1 Drives Immune Evasion in Renal Cell Carcinoma through Binding and Stabilizing JAK1.
Pan Y, Shu G, Fu L, Huang K, Zhou X, Gui C, Liu H, Jin X, Chen M, Li P, Cen J, Feng Z, Lu J, Chen Z, Li J, Xu Q, Wang Y, Liang H, Wang Z, Deng Q, Chen W, Luo J, Yang J, Zhang J, Wei J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2206792
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Apr;10(11):e2206792
IFNγ-induced PD-L1 expression in ovarian cancer cells is regulated by JAK1, STAT1 and IRF1 signaling.
Padmanabhan S, Gaire B, Zou Y, Uddin MM, Vancurova I
Cellular signalling 2022 Sep;97:110400
Cellular signalling 2022 Sep;97:110400
Periplaneta americana Extract Pretreatment Alleviates Oxidative Stress and Inflammation and Increases the Abundance of Gut Akkermansia muciniphila in Diquat-Induced Mice.
Lu S, Xu S, Chen L, Deng Y, Feng J
Antioxidants (Basel, Switzerland) 2022 Sep 13;11(9)
Antioxidants (Basel, Switzerland) 2022 Sep 13;11(9)
IL-10 contributes to gemcitabine resistance in extranodal NK/T-cell lymphoma cells via ABCC4.
Huo J, Fu L, Jin M, Li Z, Zhang M
Investigational new drugs 2022 Jun;40(3):537-545
Investigational new drugs 2022 Jun;40(3):537-545
Cannabis suppresses antitumor immunity by inhibiting JAK/STAT signaling in T cells through CNR2.
Xiong X, Chen S, Shen J, You H, Yang H, Yan C, Fang Z, Zhang J, Cai X, Dong X, Kang T, Li W, Zhou P
Signal transduction and targeted therapy 2022 Apr 6;7(1):99
Signal transduction and targeted therapy 2022 Apr 6;7(1):99
Study on the Molecular Basis of Huanglian Jiedu Decoction Against Atopic Dermatitis Integrating Chemistry, Biochemistry, and Metabolomics Strategies.
Chen J, Chen S, Chen J, Shen B, Jiang Z, Xu Y
Frontiers in pharmacology 2021;12:770524
Frontiers in pharmacology 2021;12:770524
The Anti-Inflammatory and Anti-Pruritus Mechanisms of Huanglian Jiedu Decoction in the Treatment of Atopic Dermatitis.
Xu Y, Chen S, Zhang L, Chen G, Chen J
Frontiers in pharmacology 2021;12:735295
Frontiers in pharmacology 2021;12:735295
CXCL10 Produced by HPV-Positive Cervical Cancer Cells Stimulates Exosomal PDL1 Expression by Fibroblasts via CXCR3 and JAK-STAT Pathways.
Chen X, He H, Xiao Y, Hasim A, Yuan J, Ye M, Li X, Hao Y, Guo X
Frontiers in oncology 2021;11:629350
Frontiers in oncology 2021;11:629350
Polygalaxanthone III downregulates inflammation in the lipopolysaccharide-stimulated RAW264.7 macrophages: A quantibody array analysis.
Wu Y, Fu H, Yang X, Leng F, Huang Y, Deng H, Xiang Q, Zhang S
Journal of pharmacological sciences 2021 Oct;147(2):184-191
Journal of pharmacological sciences 2021 Oct;147(2):184-191
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
Wu C, Huang ZH, Meng ZQ, Fan XT, Lu S, Tan YY, You LM, Huang JQ, Stalin A, Ye PZ, Wu ZS, Zhang JY, Liu XK, Zhou W, Zhang XM, Wu JR
Chinese medicine 2021 Nov 22;16(1):121
Chinese medicine 2021 Nov 22;16(1):121
Triptolide reduces salivary gland damage in a non-obese diabetic mice model of Sjögren's syndrome via JAK/STAT and NF-κB signaling pathways.
Guo Y, Ji W, Lu Y, Wang Y
Journal of clinical biochemistry and nutrition 2021 Mar;68(2):131-138
Journal of clinical biochemistry and nutrition 2021 Mar;68(2):131-138
Increased expression of IFN-γ in preeclampsia impairs human trophoblast invasion via a SOCS1/JAK/STAT1 feedback loop.
Liu H, Wang W, Liu C
Experimental and therapeutic medicine 2021 Feb;21(2):112
Experimental and therapeutic medicine 2021 Feb;21(2):112
CCL21/CCR7 interaction promotes EMT and enhances the stemness of OSCC via a JAK2/STAT3 signaling pathway.
Chen Y, Shao Z, Jiang E, Zhou X, Wang L, Wang H, Luo X, Chen Q, Liu K, Shang Z
Journal of cellular physiology 2020 Sep;235(9):5995-6009
Journal of cellular physiology 2020 Sep;235(9):5995-6009
TSLP Produced by Aspergillus fumigatus-Stimulated DCs Promotes a Th17 Response Through the JAK/STAT Signaling Pathway in Fungal Keratitis.
Han F, Guo H, Wang L, Zhang Y, Sun L, Dai C, Wu X
Investigative ophthalmology & visual science 2020 Dec 1;61(14):24
Investigative ophthalmology & visual science 2020 Dec 1;61(14):24
Protective Effect of Methane-Rich Saline on Acetic Acid-Induced Ulcerative Colitis via Blocking the TLR4/NF-κB/MAPK Pathway and Promoting IL-10/JAK1/STAT3-Mediated Anti-inflammatory Response.
Wang G, Xu B, Shi F, Du M, Li Y, Yu T, Chen L
Oxidative medicine and cellular longevity 2019;2019:7850324
Oxidative medicine and cellular longevity 2019;2019:7850324
Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8).
Li J, Zhou Y, Du G, Qin X, Gao L
European journal of pharmacology 2019 Dec 15;865:172789
European journal of pharmacology 2019 Dec 15;865:172789
Chemical and genetic inhibition of STAT3 sensitizes hepatocellular carcinoma cells to sorafenib induced cell death.
Xie L, Zeng Y, Dai Z, He W, Ke H, Lin Q, Chen Y, Bu J, Lin D, Zheng M
International journal of biological sciences 2018;14(5):577-585
International journal of biological sciences 2018;14(5):577-585
CEP55 Promotes Cell Motility via JAK2⁻STAT3⁻MMPs Cascade in Hepatocellular Carcinoma.
Li M, Gao J, Li D, Yin Y
Cells 2018 Aug 8;7(8)
Cells 2018 Aug 8;7(8)
LPS‑induced proinflammatory cytokine expression in human airway epithelial cells and macrophages via NF‑κB, STAT3 or AP‑1 activation.
Liu X, Yin S, Chen Y, Wu Y, Zheng W, Dong H, Bai Y, Qin Y, Li J, Feng S, Zhao P
Molecular medicine reports 2018 Apr;17(4):5484-5491
Molecular medicine reports 2018 Apr;17(4):5484-5491
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