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- Antibody Data
- Antigen structure
- References [5]
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- Western blot [1]
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- Product number
- PAB8483 - Provider product page
- Provider
- Abnova Corporation
- Proper citation
- Abnova Corporation Cat#PAB8483, RRID:AB_1673458
- Product name
- APH1A polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Rabbit polyclonal antibody raised against synthetic peptide of APH1A.
- Storage
- Store at -20°C.Aliquot to avoid repeated freezing and thawing.
Submitted references The role of presenilin cofactors in the gamma-secretase complex.
Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T
Nature 2003 Mar 27;422(6930):438-41
Nature 2003 Mar 27;422(6930):438-41
Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling.
Fortini ME
Nature reviews. Molecular cell biology 2002 Sep;3(9):673-84
Nature reviews. Molecular cell biology 2002 Sep;3(9):673-84
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch.
Lee SF, Shah S, Li H, Yu C, Han W, Yu G
The Journal of biological chemistry 2002 Nov 22;277(47):45013-9
The Journal of biological chemistry 2002 Nov 22;277(47):45013-9
aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D
Developmental cell 2002 Jul;3(1):85-97
Developmental cell 2002 Jul;3(1):85-97
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos.
Goutte C, Tsunozaki M, Hale VA, Priess JR
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 22;99(2):775-9
Proceedings of the National Academy of Sciences of the United States of America 2002 Jan 22;99(2):775-9
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- Abnova Corporation (provider)
- Main image
- Experimental details
- Western blot analysis of extract from Neuro 2a cells, using APH1A polyclonal antibody (Cat # PAB8483) . Lane 1: mock, lane 2: APH1A (247 a.a.) and lane 3: APH1A (265 a. a.) .
