APH1A

gene product
APH-1A, CGI-78
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Validated within AVI
Eligible for validation within AVI
351 antibodies from 35 providers.

Antibody properties

General

Applications

or Cancel
Antibody
Invitrogen Antibodies
8 antibodies
Novus Biologicals
6 antibodies
antibodies-online
112 antibodies
Proteintech Group
1 antibody
GeneTex
6 antibodies
Abnova Corporation
6 antibodies
LifeSpan BioSciences, Inc.
54 antibodies
Acris Antibodies GmbH
13 antibodies
NovoPro Bioscience Inc.
5 antibodies
Biorbyt
21 antibodies
NSJ Bioreagents
2 antibodies
Antibodies.com
1 antibody
OriGene
6 antibodies
Aviva Systems Biology
4 antibodies
Rockland Immunochemicals, Inc.
2 antibodies
ProSci
3 antibodies
Abgent
5 antibodies
St John's Laboratory
2 antibodies
Everest Biotech
1 antibody
RabMAbs
1 antibody
ABEOMICS Inc.
2 antibodies
Arigo
1 antibody
R&D Systems
1 antibody
MyBioSource
7 antibodies
Creative Diagnostics
6 antibodies
RayBiotech, Inc.
3 antibodies
Boster Biological Technology
1 antibody
United States Biological
39 antibodies
Leading Biology
6 antibodies
BioLegend (formerly Covance Antibody Products)
2 antibodies
Sigma-Aldrich
4 antibodies
Abbexa
3 antibodies
Creative Biolabs
1 antibody
EMD Millipore
1 antibody