Antibody data
- Antibody Data
- Antigen structure
- References [80]
- Comments [0]
- Validations
- Western blot [2]
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Validation data
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- Product number
- 60269-1-Ig - Provider product page
- Provider
- Proteintech Group
- Product name
- IL-10 antibody
- Antibody type
- Monoclonal
- Description
- IL-10 antibody (Cat. #60269-1-Ig) is a mouse monoclonal antibody that shows reactivity with human and has been validated for the following applications: IHC, WB,ELISA.
- Reactivity
- Human
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 8E4B6
- Vial size
- 20ul, 150ul
Submitted references Myeloid Deletion of Cdc42 Protects Liver From Hepatic Ischemia-Reperfusion Injury via Inhibiting Macrophage-Mediated Inflammation in Mice.
Host-microbiota interactions in collagen-induced arthritis rats treated with human umbilical cord mesenchymal stem cell exosome and ginsenoside Rh2.
Inhibition of sugar-binding activity of Galectins-8 by thiogalactoside (TDG) attenuates secondary brain damage and improves long-term prognosis following intracerebral hemorrhage.
Development of Zn(2+)-controlled expression system for lactic acid bacteria and its application in engineered probiotics.
CD146(+)CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway.
Anti-inflammatory and anti-oxidative electrospun nanofiber membrane promotes diabetic wound healing via macrophage modulation.
Human amniotic MSCs-mediated anti-inflammation of CD206(hi)IL-10(hi) macrophages alleviates isoproterenol-induced ventricular remodeling in mice.
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
Platelet membrane biomimetic nanoparticle-targeted delivery of TGF-β1 siRNA attenuates renal inflammation and fibrosis.
ZeXieYin formula alleviates atherosclerosis by inhibiting the MAPK/NF-κB signaling pathway in APOE-/- mice to attenuate vascular inflammation and increase plaque stability.
Interleukin-10: a novel metabolic inducer of macrophage differentiation and subsequently contributing to improved pregnancy outcomes of mice by orchestrating oxidative phosphorylation metabolism†.
D-Mannose reduces cellular senescence and NLRP3/GasderminD/IL-1β-driven pyroptotic uroepithelial cell shedding in the murine bladder.
Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
Single-Cell Transcriptomic Sequencing Reveals Tissue Architecture and Deciphers Pathological Reprogramming During Retinal Ischemia in Macaca fascicularis.
Co-expression of regulatory B-cell markers, transforming growth factor β and interleukin-10 as a prognostic factor in diffuse large B-cell lymphoma.
Chitosan-crosslinked polyvinyl alcohol anti-swelling hydrogel designed to prevent abdominal wall adhesion.
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
Silencing CXCL16 alleviate neuroinflammation and M1 microglial polarization in mouse brain hemorrhage model and BV2 cell model through PI3K/AKT pathway.
A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds.
LC-MS/MS analysis of Shenghui decoction component and its effect on learning and memory and neuroprotection in sleep deprivation model mice.
Investigating the impact of regulatory B cells and regulatory B cell-related genes on bladder cancer progression and immunotherapeutic sensitivity.
Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice.
A multifunctional polydopamine/genipin/alendronate nanoparticle licences fibrin hydrogels osteoinductive and immunomodulatory potencies for repairing bone defects.
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF-κB signaling.
Secretome of EMSCs neutralizes LPS‑induced acute lung injury via aerosol administration.
Role of nuclear factor of activated T Cells-1 in Sepsis-induced behavioral deficits in mice.
ROS-activated MAPK/ERK pathway regulates crosstalk between Nrf2 and Hif-1α to promote IL-17D expression protecting the intestinal epithelial barrier under hyperoxia.
Long-Term Immunogenicity and In Vitro Prophylactic Protective Efficacy of M. tuberculosis Fusion Protein DR2 Combined with Liposomal Adjuvant DIMQ as a Boosting Vaccine for BCG.
Peripheral Klotho protects the kidney and brain by regulating M2a/M2c macrophage polarization in d-gal-treated aged mice.
Continuously released Zn(2+) in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties.
Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice.
Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2.
Diets Differently Regulate Pulmonary Pathogenesis and Immune Signaling in Mice during Acute and Chronic Mycobacterium tuberculosis Infection.
Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway.
CXCL chemokines-mediated communication between macrophages and BMSCs on titanium surface promotes osteogenesis via the actin cytoskeleton pathway.
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
α-Lipoic acid alleviates myocardial injury and induces M2b macrophage polarization after myocardial infarction via HMGB1/NF-kB signaling pathway.
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
Systemic Pharmacology Reveals the Potential Targets and Signaling Mechanisms in the Adjuvant Treatment of Brucellosis with Traditional Chinese Medicine.
Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity.
Repairing gastric ulcer with hyaluronic acid/extracellular matrix composite through promoting M2-type polarization of macrophages.
Human placental extract regulates polarization of macrophages via IRGM/NLRP3 in allergic rhinitis.
Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes In Vivo and In Vitro.
Red Nucleus Interleukin-6 Evokes Tactile Allodynia in Male Rats Through Modulating Spinal Pro-inflammatory and Anti-inflammatory Cytokines.
The Assessment on Synergistic Activity of Ebselen and Silver Ion Against Yersinia pseudotuberculosis.
Distinct immune and inflammatory response patterns contribute to the identification of poor prognosis and advanced clinical characters in bladder cancer patients.
Protective effects of (R)-enantiomers but not (S)-enantiomers of β2-adrenergic receptor agonists against acute colitis: The role of β2AR.
LFA-1/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model.
Identification of hub genes, signaling pathways and immune infiltration of recurrent spontaneous abortion based on bioinformatics analysis with clinical verification.
The Clostridium Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Polydopamine Decorated Microneedles with Fe-MSC-Derived Nanovesicles Encapsulation for Wound Healing.
Quercetin Alleviates Demyelination Through Regulating Microglial Phenotype Transformation to Mitigate Neuropsychiatric Symptoms in Mice with Vascular Dementia.
Enhanced immunogenicity of the tuberculosis subunit Rv0572c vaccine delivered in DMT liposome adjuvant as a BCG-booster.
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Helicobacter pylori infection disturbs the tumor immune microenvironment and is associated with a discrepant prognosis in gastric de novo diffuse large B-cell lymphoma.
Upregulation of TRPC5 in hippocampal excitatory synapses improves memory impairment associated with neuroinflammation in microglia knockout IL-10 mice.
Phosphorylated nuclear factor erythroid 2-related factor 2 promotes the secretion of C-C motif chemokine ligand 2 and the recruitment of M2 macrophages.
Plasminogen Activator Urokinase Receptor Implies Immunosuppressive Features and Acts as an Unfavorable Prognostic Biomarker in Glioma.
Non-neuronal crosstalk promotes an inflammatory response in nodose ganglia cultures after exposure to byproducts from gram positive, high-fat-diet-associated gut bacteria.
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Comparative Immunopathology of Cetacean morbillivirus Infection in Free-Ranging Dolphins From Western Mediterranean, Northeast-Central, and Southwestern Atlantic.
Molecular changes in peripheral blood involving osteoarthritic joint remodelling.
Bisperoxovanadium induces M2-type macrophages and promotes functional recovery after spinal cord injury.
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Upregulated Expression of microRNA-16 Correlates with Th17/Treg Cell Imbalance in Patients with Rheumatoid Arthritis.
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Host-microbiota interactions in collagen-induced arthritis rats treated with human umbilical cord mesenchymal stem cell exosome and ginsenoside Rh2.
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Inhibition of sugar-binding activity of Galectins-8 by thiogalactoside (TDG) attenuates secondary brain damage and improves long-term prognosis following intracerebral hemorrhage.
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CD146(+)CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway.
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Human amniotic MSCs-mediated anti-inflammation of CD206(hi)IL-10(hi) macrophages alleviates isoproterenol-induced ventricular remodeling in mice.
Huang QM, Long YL, Wang JN, Wu J, Tang WL, Wang XY, Zhang ZH, Zhuo YQ, Guan XH, Deng KY, Xin HB
International immunopharmacology 2024 Mar 10;129:111660
International immunopharmacology 2024 Mar 10;129:111660
Atractylenolide-III attenuates osteoarthritis by repolarizing macrophages through inactivating TLR4/NF-κB signaling.
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International immunopharmacology 2024 Mar 10;129:111629
Platelet membrane biomimetic nanoparticle-targeted delivery of TGF-β1 siRNA attenuates renal inflammation and fibrosis.
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International journal of pharmaceutics 2024 Jun 25;659:124261
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Interleukin-10: a novel metabolic inducer of macrophage differentiation and subsequently contributing to improved pregnancy outcomes of mice by orchestrating oxidative phosphorylation metabolism†.
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Biology of reproduction 2024 Jul 12;111(1):76-91
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Single-Cell Transcriptomic Sequencing Reveals Tissue Architecture and Deciphers Pathological Reprogramming During Retinal Ischemia in Macaca fascicularis.
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Materials today. Bio 2024 Feb;24:100931
Materials today. Bio 2024 Feb;24:100931
Alleviative Effect of Lactoferrin Interventions Against the Hepatotoxicity Induced by Titanium Dioxide Nanoparticles.
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Biological trace element research 2024 Feb;202(2):624-642
Silencing CXCL16 alleviate neuroinflammation and M1 microglial polarization in mouse brain hemorrhage model and BV2 cell model through PI3K/AKT pathway.
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Experimental brain research 2024 Aug;242(8):1917-1932
A bioactive composite hydrogel dressing that promotes healing of both acute and chronic diabetic skin wounds.
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Bioactive materials 2024 Apr;34:298-310
LC-MS/MS analysis of Shenghui decoction component and its effect on learning and memory and neuroprotection in sleep deprivation model mice.
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Fitoterapia 2024 Apr;174:105823
Investigating the impact of regulatory B cells and regulatory B cell-related genes on bladder cancer progression and immunotherapeutic sensitivity.
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Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish.
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Frontiers in endocrinology 2023;14:1162485
rhFGF-21 accelerates corneal epithelial wound healing through the attenuation of oxidative stress and inflammatory mediators in diabetic mice.
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The Journal of biological chemistry 2023 Sep;299(9):105127
A multifunctional polydopamine/genipin/alendronate nanoparticle licences fibrin hydrogels osteoinductive and immunomodulatory potencies for repairing bone defects.
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International journal of biological macromolecules 2023 Sep 30;249:126072
Melatonin or vitamin C attenuates lead acetate-induced testicular oxidative and inflammatory damage in mice by inhibiting oxidative stress mediated NF-κB signaling.
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Ecotoxicology and environmental safety 2023 Oct 1;264:115481
Secretome of EMSCs neutralizes LPS‑induced acute lung injury via aerosol administration.
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International journal of molecular medicine 2023 Nov;52(5)
International journal of molecular medicine 2023 Nov;52(5)
Role of nuclear factor of activated T Cells-1 in Sepsis-induced behavioral deficits in mice.
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Brain research 2023 May 1;1806:148299
ROS-activated MAPK/ERK pathway regulates crosstalk between Nrf2 and Hif-1α to promote IL-17D expression protecting the intestinal epithelial barrier under hyperoxia.
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International immunopharmacology 2023 Mar;116:109763
Long-Term Immunogenicity and In Vitro Prophylactic Protective Efficacy of M. tuberculosis Fusion Protein DR2 Combined with Liposomal Adjuvant DIMQ as a Boosting Vaccine for BCG.
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ACS infectious diseases 2023 Mar 10;9(3):593-608
ACS infectious diseases 2023 Mar 10;9(3):593-608
Peripheral Klotho protects the kidney and brain by regulating M2a/M2c macrophage polarization in d-gal-treated aged mice.
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Tissue & cell 2023 Jun;82:102049
Continuously released Zn(2+) in 3D-printed PLGA/β-TCP/Zn scaffolds for bone defect repair by improving osteoinductive and anti-inflammatory properties.
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Bioactive materials 2023 Jun;24:361-375
Bioactive materials 2023 Jun;24:361-375
Minocycline, a classic antibiotic, exerts psychotropic effects by normalizing microglial neuroinflammation-evoked tryptophan-kynurenine pathway dysregulation in chronically stressed male mice.
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Brain, behavior, and immunity 2023 Jan;107:305-318
Azithromycin attenuates wheezing after pulmonary inflammation through inhibiting histone H3K27me3 hypermethylation mediated by EZH2.
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Clinical epigenetics 2023 Jan 23;15(1):12
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Life (Basel, Switzerland) 2023 Jan 13;13(1)
Castor1 overexpression regulates microglia M1/M2 polarization via inhibiting mTOR pathway.
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Metabolic brain disease 2023 Feb;38(2):699-708
CXCL chemokines-mediated communication between macrophages and BMSCs on titanium surface promotes osteogenesis via the actin cytoskeleton pathway.
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Materials today. Bio 2023 Dec;23:100816
Materials today. Bio 2023 Dec;23:100816
Aloin Attenuates Oxidative Stress, Inflammation, and CCl(4)-Induced Liver Fibrosis in Mice: Possible Role of TGF-β/Smad Signaling.
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Journal of agricultural and food chemistry 2023 Dec 13;71(49):19475-19487
α-Lipoic acid alleviates myocardial injury and induces M2b macrophage polarization after myocardial infarction via HMGB1/NF-kB signaling pathway.
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International immunopharmacology 2023 Aug;121:110435
International immunopharmacology 2023 Aug;121:110435
Tumor-secreted GRP78 induces M2 polarization of macrophages by promoting lipid catabolism.
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Cellular signalling 2023 Aug;108:110719
Systemic Pharmacology Reveals the Potential Targets and Signaling Mechanisms in the Adjuvant Treatment of Brucellosis with Traditional Chinese Medicine.
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ACS omega 2023 Aug 8;8(31):28797-28812
ACS omega 2023 Aug 8;8(31):28797-28812
Expression of the readthrough transcript CiDRE in alveolar macrophages boosts SARS-CoV-2 susceptibility and promotes COVID-19 severity.
Mitsui Y, Suzuki T, Kuniyoshi K, Inamo J, Yamaguchi K, Komuro M, Watanabe J, Edamoto M, Li S, Kouno T, Oba S, Hosoya T, Masuhiro K, Naito Y, Koyama S, Sakaguchi N, Standley DM, Shin JW, Akira S, Yasuda S, Miyazaki Y, Kochi Y, Kumanogoh A, Okamoto T, Satoh T
Immunity 2023 Aug 8;56(8):1939-1954.e12
Immunity 2023 Aug 8;56(8):1939-1954.e12
Repairing gastric ulcer with hyaluronic acid/extracellular matrix composite through promoting M2-type polarization of macrophages.
Ni R, Luo Y, Jiang L, Mao X, Feng Y, Tuersun S, Hu Z, Zhu Y
International journal of biological macromolecules 2023 Aug 1;245:125556
International journal of biological macromolecules 2023 Aug 1;245:125556
Human placental extract regulates polarization of macrophages via IRGM/NLRP3 in allergic rhinitis.
Wo B, Du C, Yang Y, Qi H, Liang Z, He C, Yao F, Li X
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2023 Apr;160:114363
Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes In Vivo and In Vitro.
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Oxidative medicine and cellular longevity 2022;2022:3800004
Oxidative medicine and cellular longevity 2022;2022:3800004
Red Nucleus Interleukin-6 Evokes Tactile Allodynia in Male Rats Through Modulating Spinal Pro-inflammatory and Anti-inflammatory Cytokines.
Yang QQ, Li HN, Xia YT, Tian X, Feng F, Yang J, Xu YL, Guo J, Li XQ, Wang JY, Zeng XY
Frontiers in molecular neuroscience 2022;15:820664
Frontiers in molecular neuroscience 2022;15:820664
The Assessment on Synergistic Activity of Ebselen and Silver Ion Against Yersinia pseudotuberculosis.
Dong C, Chen W, Zou L, Liu B, Deng K, Guo D, Wang P, Chen H, Wang H, Wang J
Frontiers in microbiology 2022;13:963901
Frontiers in microbiology 2022;13:963901
Distinct immune and inflammatory response patterns contribute to the identification of poor prognosis and advanced clinical characters in bladder cancer patients.
Chang Z, Li R, Zhang J, An L, Zhou G, Lei M, Deng J, Yang R, Song Z, Zhong W, Qi D, Duan X, Li S, Sun B, Wu W
Frontiers in immunology 2022;13:1008865
Frontiers in immunology 2022;13:1008865
Protective effects of (R)-enantiomers but not (S)-enantiomers of β2-adrenergic receptor agonists against acute colitis: The role of β2AR.
Deng L, Wang S, Zhang R, Huang J, Lin Y, Liu X, Lu Z, Li M, Tan W
International immunopharmacology 2022 Sep;110:108997
International immunopharmacology 2022 Sep;110:108997
LFA-1/ ICAM-1 promotes NK cell cytotoxicity associated with the pathogenesis of ocular toxoplasmosis in murine model.
Gao N, Wang C, Yu Y, Xie L, Xing Y, Zhang Y, Wang Y, Wu J, Cai Y
PLoS neglected tropical diseases 2022 Oct;16(10):e0010848
PLoS neglected tropical diseases 2022 Oct;16(10):e0010848
Identification of hub genes, signaling pathways and immune infiltration of recurrent spontaneous abortion based on bioinformatics analysis with clinical verification.
Chen YX, Zhang QQ, Ge C, Yang J
Taiwanese journal of obstetrics & gynecology 2022 Nov;61(6):1027-1036
Taiwanese journal of obstetrics & gynecology 2022 Nov;61(6):1027-1036
The Clostridium Metabolite P-Cresol Sulfate Relieves Inflammation of Primary Biliary Cholangitis by Regulating Kupffer Cells.
Fu HY, Xu JM, Ai X, Dang FT, Tan X, Yu HY, Feng J, Yang WX, Ma HT, Tu RF, Gupta AK, Manandhar LK, Bao WM, Tang YM
Cells 2022 Nov 26;11(23)
Cells 2022 Nov 26;11(23)
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Polydopamine Decorated Microneedles with Fe-MSC-Derived Nanovesicles Encapsulation for Wound Healing.
Ma W, Zhang X, Liu Y, Fan L, Gan J, Liu W, Zhao Y, Sun L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(13):e2103317
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 May;9(13):e2103317
Quercetin Alleviates Demyelination Through Regulating Microglial Phenotype Transformation to Mitigate Neuropsychiatric Symptoms in Mice with Vascular Dementia.
Tan Z, Yang G, Qiu J, Yan W, Liu Y, Ma Z, Li J, Liu J, Shan N
Molecular neurobiology 2022 May;59(5):3140-3158
Molecular neurobiology 2022 May;59(5):3140-3158
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Mao L, Xu L, Wang X, Xing Y, Wang J, Zhang Y, Yuan W, Du J, Shi Z, Ma J, Zhang J, Zhang X, Wang X
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International journal of molecular medicine 2022 Jul;50(1)
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DNA and cell biology 2016 Dec;35(12):853-860
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with 60269-1-Ig( IL10 Antibody) at dilution of 1:1000
- Sample type
- cell line
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The IL-10 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human IL-10. This antibody recognizes human antigen. The IL-10 antibody has been validated for the following applications: ELISA, WB analysis.