IL10

gene product
CSIF, IL-10, IL10A, TGIF
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2011]
More gene data

Antibodies

 

Filters

Application

Antibodypedia Validation Initiative

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
1460 antibodies from 42 providers.

Antibody properties

General

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
R&D Systems
46 antibodies
GeneTex
37 antibodies
Novus Biologicals
78 antibodies
antibodies-online
440 antibodies
Invitrogen Antibodies
35 antibodies
Boster Biological Technology
6 antibodies
Biorbyt
96 antibodies
Aviva Systems Biology
20 antibodies
OriGene
35 antibodies
BioLegend
33 antibodies
Acris Antibodies GmbH
44 antibodies
NSJ Bioreagents
9 antibodies
Affinity Biosciences
2 antibodies
Abgent
8 antibodies