BS6920

antibody from Bioworld Technology, Inc
Targeting: IL10 CSIF, IL-10, IL10A, TGIF
Provider product page for BS6920
Western blot
Immunohistochemistry

Antibody data

Product number
BS6920 - Provider product page
Provider
Bioworld Technology, Inc
Product name
IL10 polyclonal antibody
Antibody type
Polyclonal
Antigen
Recombinant full length Human IL10.
Description
IL-10 is an anti-inflammatory cytokine that is produced by T cells, NK cells and macrophages. IL-10 initiates signal transduction by binding to a cell surface receptor complex consisting of IL-10 RI and IL-10 RII. Binding of IL-10 leads to the activation of Jak1 and Tyk2, which phosphorylates Stat-3 . The anti-inflammatory activity of IL-10 is due to its ability to block signaling through other cytokine receptors, notably IFNÎÛ receptor, by upregulating expression of SOCS-1. In addition, IL-10 promotes T cell tolerance by inhibiting tyrosine phosphorylation of CD28. IL-10 is an important negative regulator of the immune response, which allows for maintenance of pregnancy . In contrast, increased IL-10 levels contribute to persistent Leishmania major infections.
Reactivity
Human, Mouse, Rat
Host
Rabbit
Isotype
IgG
Vial size
100ul
Concentration
1 mg/ml
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
IL10 protein structure - BS6920 shown in red.