BMS131-2

antibody from Invitrogen Antibodies
Targeting: IL10 CSIF, IL-10, IL10A, TGIF
Provider product page for BMS131-2
ELISA

Antibody data

Product number
BMS131-2 - Provider product page
Provider
Invitrogen Antibodies
Product name
IL-10 Monoclonal Antibody (BT-10), eBioscience™
Antibody type
Monoclonal
Antigen
Other
Description
Description: IL-10 (BT-10) is a mouse monoclonal antibody raised against IL-10 of human origin. BMS 131/2 is recommended for detection of IL-10 of human origin by solid phase ELISA. Interleukin-10 is a regulator of lymphoid and myeloid cell function. In humans IL-10 is produced by activated CD8(+) peripheral blood T-cells, by T-helper CD4(+) T-cell clones. Due to the ability of IL-10 to block cytokine synthesis and several accessory cell functions of macrophages this cytokine is a potent suppressor of the effector functions of macrophages, T-cells and NK cells. In addition, IL-10 participates in regulating proliferation and differentiation of B-cells, mast cells and thymocytes. The corresponding protein exerts 160 amino acids with a predicted molecular mass of 18.5 kDa. Based on its primary structure, IL-10 is a member of the four a-helix bundle family of cytokines. In solution human IL-10 is a homodimer with an apparent molecular mass of 39 kDa. Although it contains an N-linked, glycosylation site, it lacks detectable carbohydrates. The immunosuppressive properties of IL-10 suggest a possible clinical use of IL-10 in suppressing rejections of grafts after organ transplantations. IL-10 can furthermore exert strong anti-inflammatory activities. Purity is greater than 95% IgG1 as determined by SDS-PAGE.
Reactivity
Human
Host
Mouse
Isotype
IgG
Antibody clone number
BT-10
Vial size
100 µg
Concentration
1 mg/mL
Storage
4° C
IL10 protein structure - BMS131-2 shown in red.