ABIN358793

antibody from antibodies-online

Targeting: GRB2 NCKAP2

Western blot (Recommended by provider)

ELISA (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN358793

Provider

antibodies-online

Product name

anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (Tyr209) antibody

Antibody type

Polyclonal

Antigen

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide corresponding to amino acid residues surrounding Y209 of human GRB2.

Description

Protein A column, followed by peptide affinity purification

Reactivity

Human

Host

Rabbit

Epitope

Tyr209

Vial size

0.4 mL

Concentration

0.25 mg/mL

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation.

Kondo A, Hirayama N, Sugito Y, Shono M, Tanaka T, Kitamura N
The Journal of biological chemistry 2008 Jan 18;283(3):1428-36

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Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction.

Martínez N, García-Domínguez CA, Domingo B, Oliva JL, Zarich N, Sánchez A, Gutiérrez-Eisman S, Llopis J, Rojas JM
Cellular signalling 2007 Nov;19(11):2277-85

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Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.

Morimatsu M, Takagi H, Ota KG, Iwamoto R, Yanagida T, Sako Y
Proceedings of the National Academy of Sciences of the United States of America 2007 Nov 13;104(46):18013-8