ABIN358795

antibody from antibodies-online

Targeting: GRB2 NCKAP2

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN358795

Provider

antibodies-online

Product name

anti-Growth Factor Receptor-Bound Protein 2 (GRB2) (Middle Region) antibody

Antibody type

Polyclonal

Description

Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS

Reactivity

Human

Host

Rabbit

Epitope

Middle Region

Vial size

0.4 mL

Storage

Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.

Handling

Avoid repeated freezing and thawing.

References

Submitted references

Coupling of Grb2 to Gab1 mediates hepatocyte growth factor-induced high intensity ERK signal required for inhibition of HepG2 hepatoma cell proliferation.

Kondo A, Hirayama N, Sugito Y, Shono M, Tanaka T, Kitamura N
The Journal of biological chemistry 2008 Jan 18;283(3):1428-36

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Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction.

Martínez N, García-Domínguez CA, Domingo B, Oliva JL, Zarich N, Sánchez A, Gutiérrez-Eisman S, Llopis J, Rojas JM
Cellular signalling 2007 Nov;19(11):2277-85

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Multiple-state reactions between the epidermal growth factor receptor and Grb2 as observed by using single-molecule analysis.

Morimatsu M, Takagi H, Ota KG, Iwamoto R, Yanagida T, Sako Y
Proceedings of the National Academy of Sciences of the United States of America 2007 Nov 13;104(46):18013-8