Antibody data
- Antibody Data
- Antigen structure
- References [114]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
- Other assay [3]
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Validation data
Reference
Comment
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- Product number
- 44-660G - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- Phospho-SRC (Tyr419) Polyclonal Antibody
- Antibody type
- Polyclonal
- Antigen
- Synthetic peptide
- Reactivity
- Human, Mouse, Chicken/Avian
- Host
- Rabbit
- Isotype
- IgG
- Vial size
- 100 µL
- Storage
- -20°C
Submitted references Peruvoside is a novel Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways.
Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ.
Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function.
LY6D-induced macropinocytosis as a survival mechanism of senescent cells.
Identification of a Dexamethasone Mediated Radioprotection Mechanism Reveals New Therapeutic Vulnerabilities in Glioblastoma.
Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila.
eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin.
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration.
Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.
Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination.
Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels.
A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade.
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly.
Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin.
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.
The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma.
Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling.
Pioneer axons employ Cajal's battering ram to enter the spinal cord.
The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis.
Intermittent hypoxia alleviates increased VEGF and pro-angiogenic potential in liver cancer cells.
High Glucose Concentrations Negatively Regulate the IGF1R/Src/ERK Axis through the MicroRNA-9 in Colorectal Cancer.
Na/K-ATPase signaling mediates miR-29b-3p regulation and cardiac fibrosis formation in mice with chronic kidney disease.
Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes.
A whole-animal platform to advance a clinical kinase inhibitor into new disease space.
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies.
miR205 inhibits stem cell renewal in SUM159PT breast cancer cells.
Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma.
Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia.
The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma.
Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells.
Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia.
Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation.
Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.
Regulation of RhoA by STAT3 coordinates glial scar formation.
Tumor endothelial cells promote metastasis and cancer stem cell-like phenotype through elevated Epiregulin in esophageal cancer.
Ischemia/reperfusion-induced alterations of enzymatic and signaling functions of the rat cardiac Na+/K+-ATPase: protection by ouabain preconditioning.
Functional exploration of colorectal cancer genomes using Drosophila.
GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries.
Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts.
Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells.
AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin.
Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination.
Urokinase is a negative modulator of Egf-dependent proliferation and motility in the two breast cancer cell lines MCF-7 and MDA-MB-231.
Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic.
Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521.
FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.
GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.
Aurora A drives early signalling and vesicle dynamics during T-cell activation.
α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation.
TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions.
Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells.
Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia.
Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland.
Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.
SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2.
Dihydrotestosterone potentiates EGF-induced ERK activation by inducing SRC in fetal lung fibroblasts.
c-Src drives intestinal regeneration and transformation.
EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence.
c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src.
Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways.
Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression.
α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.
Activation of Src and release of intracellular calcium by phosphatidic acid during Xenopus laevis fertilization.
The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis.
Dissecting motility signaling through activation of specific Src-effector complexes.
Digitalis-induced cell signaling by the sodium pump: on the relation of Src to Na(+)/K(+)-ATPase.
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.
Novel role of MDA-9/syntenin in regulating urothelial cell proliferation by modulating EGFR signaling.
Phosphatidylinositol phosphate 5-kinase Iγi2 in association with Src controls anchorage-independent growth of tumor cells.
Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.
Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.
Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.
Na,K-ATPase activity modulates Src activation: a role for ATP/ADP ratio.
Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size.
Biophysical stimulation induces demyelination via an integrin-dependent mechanism.
Stat3 is a positive regulator of gap junctional intercellular communication in cultured, human lung carcinoma cells.
The CXCL12/CXCR4 axis promotes ligand-independent activation of the androgen receptor.
Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells.
VEGF mediates commissural axon chemoattraction through its receptor Flk1.
cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain.
zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation.
zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation.
Androgens activate mitogen-activated protein kinase via epidermal growth factor receptor/insulin-like growth factor 1 receptor in the mouse PC-1 cell line.
Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.
Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines.
SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion.
Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines.
Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells.
The simian virus 40 large tumor antigen activates cSrc and requires cSrc for full neoplastic transformation.
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53.
Interstitial fluid flow intensity modulates endothelial sprouting in restricted Src-activated cell clusters during capillary morphogenesis.
ADAM-mediated amphiregulin shedding and EGFR transactivation.
The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1.
Src inhibition ameliorates polycystic kidney disease.
Sphingosine 1-phosphate induces platelet/endothelial cell adhesion molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn.
Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.
Platelet integrin adhesive functions and signaling.
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.
Analyzing FAK and Pyk2 in early integrin signaling events.
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress.
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.
(alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells.
Reelin activates SRC family tyrosine kinases in neurons.
Reelin activates SRC family tyrosine kinases in neurons.
Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression.
The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions.
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration.
Lai Y, Chang H, Chen H, Chang G, Chen JJ
American journal of cancer research 2022;12(6):2576-2593
American journal of cancer research 2022;12(6):2576-2593
Phagocytosis mediated by the human granulocyte receptor CEACAM3 is limited by the receptor-type protein tyrosine phosphatase PTPRJ.
Goob G, Adrian J, Cossu C, Hauck CR
The Journal of biological chemistry 2022 Sep;298(9):102269
The Journal of biological chemistry 2022 Sep;298(9):102269
Migraine-Associated Mutation in the Na,K-ATPase Leads to Disturbances in Cardiac Metabolism and Reduced Cardiac Function.
Staehr C, Rohde PD, Krarup NT, Ringgaard S, Laustsen C, Johnsen J, Nielsen R, Beck HC, Morth JP, Lykke-Hartmann K, Jespersen NR, Abramochkin D, Nyegaard M, Bøtker HE, Aalkjaer C, Matchkov V
Journal of the American Heart Association 2022 Apr 5;11(7):e021814
Journal of the American Heart Association 2022 Apr 5;11(7):e021814
LY6D-induced macropinocytosis as a survival mechanism of senescent cells.
Nagano T, Iwasaki T, Onishi K, Awai Y, Terachi A, Kuwaba S, Asano S, Katasho R, Nagai K, Nakashima A, Kikkawa U, Kamada S
The Journal of biological chemistry 2021 Jan-Jun;296:100049
The Journal of biological chemistry 2021 Jan-Jun;296:100049
Identification of a Dexamethasone Mediated Radioprotection Mechanism Reveals New Therapeutic Vulnerabilities in Glioblastoma.
Aldaz P, Auzmendi-Iriarte J, Durántez M, Lasheras-Otero I, Carrasco-Garcia E, Zelaya MV, Bragado L, Olías-Arjona A, Egaña L, Samprón N, Morilla I, Redondo-Muñoz M, Rico M, Squatrito M, Maria-Alonso M, Fernández-Irigoyen J, Santamaria E, Larráyoz IM, Wellbrock C, Matheu A, Arozarena I
Cancers 2021 Jan 19;13(2)
Cancers 2021 Jan 19;13(2)
Interaction between Ras and Src clones causes interdependent tumor malignancy via Notch signaling in Drosophila.
Enomoto M, Takemoto D, Igaki T
Developmental cell 2021 Aug 9;56(15):2223-2236.e5
Developmental cell 2021 Aug 9;56(15):2223-2236.e5
eNOS-induced vascular barrier disruption in retinopathy by c-Src activation and tyrosine phosphorylation of VE-cadherin.
Ninchoji T, Love DT, Smith RO, Hedlund M, Vestweber D, Sessa WC, Claesson-Welsh L
eLife 2021 Apr 28;10
eLife 2021 Apr 28;10
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration.
Sorrentino G, Perino A, Yildiz E, El Alam G, Bou Sleiman M, Gioiello A, Pellicciari R, Schoonjans K
Gastroenterology 2020 Sep;159(3):956-968.e8
Gastroenterology 2020 Sep;159(3):956-968.e8
Sequential Ras/MAPK and PI3K/AKT/mTOR pathways recruitment drives basal extrusion in the prostate-like gland of Drosophila.
Rambur A, Lours-Calet C, Beaudoin C, Buñay J, Vialat M, Mirouse V, Trousson A, Renaud Y, Lobaccaro JA, Baron S, Morel L, de Joussineau C
Nature communications 2020 May 8;11(1):2300
Nature communications 2020 May 8;11(1):2300
Crosstalk with lung epithelial cells regulates Sfrp2-mediated latency in breast cancer dissemination.
Montagner M, Bhome R, Hooper S, Chakravarty P, Qin X, Sufi J, Bhargava A, Ratcliffe CDH, Naito Y, Pocaterra A, Tape CJ, Sahai E
Nature cell biology 2020 Mar;22(3):289-296
Nature cell biology 2020 Mar;22(3):289-296
Circulating Ouabain Modulates Expression of Claudins in Rat Intestine and Cerebral Blood Vessels.
Markov AG, Fedorova AA, Kravtsova VV, Bikmurzina AE, Okorokova LS, Matchkov VV, Cornelius V, Amasheh S, Krivoi II
International journal of molecular sciences 2020 Jul 17;21(14)
International journal of molecular sciences 2020 Jul 17;21(14)
A Comprehensive Tyrosine Phosphoproteomic Analysis Reveals Novel Components of the Platelet CLEC-2 Signaling Cascade.
Izquierdo I, Barrachina MN, Hermida-Nogueira L, Casas V, Morán LA, Lacerenza S, Pinto-Llorente R, Eble JA, de Los Ríos V, Domínguez E, Loza MI, Casal JI, Carrascal M, Abián J, García A
Thrombosis and haemostasis 2020 Feb;120(2):262-276
Thrombosis and haemostasis 2020 Feb;120(2):262-276
c-Src controls stability of sprouting blood vessels in the developing retina independently of cell-cell adhesion through focal adhesion assembly.
Schimmel L, Fukuhara D, Richards M, Jin Y, Essebier P, Frampton E, Hedlund M, Dejana E, Claesson-Welsh L, Gordon E
Development (Cambridge, England) 2020 Apr 6;147(7)
Development (Cambridge, England) 2020 Apr 6;147(7)
Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin.
Smith RO, Ninchoji T, Gordon E, André H, Dejana E, Vestweber D, Kvanta A, Claesson-Welsh L
eLife 2020 Apr 21;9
eLife 2020 Apr 21;9
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease Risk.
Huang YA, Zhou B, Nabet AM, Wernig M, Südhof TC
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Sep 11;39(37):7408-7427
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Sep 11;39(37):7408-7427
The Differential Impact of SRC Expression on the Prognosis of Patients with Head and Neck Squamous Cell Carcinoma.
Hermida-Prado F, Granda-Díaz R, Del-Río-Ibisate N, Villaronga MÁ, Allonca E, Garmendia I, Montuenga LM, Rodríguez R, Vallina A, Alvarez-Marcos C, Rodrigo JP, García-Pedrero JM
Cancers 2019 Oct 25;11(11)
Cancers 2019 Oct 25;11(11)
Metabolic Syndrome and Salt-Sensitive Hypertension in Polygenic Obese TALLYHO/JngJ Mice: Role of Na/K-ATPase Signaling.
Yan Y, Wang J, Chaudhry MA, Nie Y, Sun S, Carmon J, Shah PT, Bai F, Pratt R, Brickman C, Sodhi K, Kim JH, Pierre S, Malhotra D, Rankin GO, Xie ZJ, Shapiro JI, Liu J
International journal of molecular sciences 2019 Jul 16;20(14)
International journal of molecular sciences 2019 Jul 16;20(14)
Pioneer axons employ Cajal's battering ram to enter the spinal cord.
Nichols EL, Smith CJ
Nature communications 2019 Feb 4;10(1):562
Nature communications 2019 Feb 4;10(1):562
The spectraplakin Dystonin antagonizes YAP activity and suppresses tumourigenesis.
Jain PB, Guerreiro PS, Canato S, Janody F
Scientific reports 2019 Dec 27;9(1):19843
Scientific reports 2019 Dec 27;9(1):19843
Intermittent hypoxia alleviates increased VEGF and pro-angiogenic potential in liver cancer cells.
Dong G, Lin XH, Liu HH, Gao DM, Cui JF, Ren ZG, Chen RX
Oncology letters 2019 Aug;18(2):1831-1839
Oncology letters 2019 Aug;18(2):1831-1839
High Glucose Concentrations Negatively Regulate the IGF1R/Src/ERK Axis through the MicroRNA-9 in Colorectal Cancer.
Chen YC, Ou MC, Fang CW, Lee TH, Tzeng SL
Cells 2019 Apr 8;8(4)
Cells 2019 Apr 8;8(4)
Na/K-ATPase signaling mediates miR-29b-3p regulation and cardiac fibrosis formation in mice with chronic kidney disease.
Drummond CA, Fan X, Haller ST, Kennedy DJ, Liu J, Tian J
PloS one 2018;13(5):e0197688
PloS one 2018;13(5):e0197688
Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes.
Hoch-Kraft P, White R, Tenzer S, Krämer-Albers EM, Trotter J, Gonsior C
Journal of cell science 2018 May 1;131(9)
Journal of cell science 2018 May 1;131(9)
A whole-animal platform to advance a clinical kinase inhibitor into new disease space.
Sonoshita M, Scopton AP, Ung PMU, Murray MA, Silber L, Maldonado AY, Real A, Schlessinger A, Cagan RL, Dar AC
Nature chemical biology 2018 Mar;14(3):291-298
Nature chemical biology 2018 Mar;14(3):291-298
A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies.
Takada M, Parys M, Gregory-Bryson E, Vilar Saavedra P, Kiupel M, Yuzbasiyan-Gurkan V
BMC cancer 2018 Mar 1;18(1):237
BMC cancer 2018 Mar 1;18(1):237
miR205 inhibits stem cell renewal in SUM159PT breast cancer cells.
Mayoral-Varo V, Calcabrini A, Sánchez-Bailón MP, Martín-Pérez J
PloS one 2017;12(11):e0188637
PloS one 2017;12(11):e0188637
Male hormones activate EphA2 to facilitate Kaposi's sarcoma-associated herpesvirus infection: Implications for gender disparity in Kaposi's sarcoma.
Wang X, Zou Z, Deng Z, Liang D, Zhou X, Sun R, Lan K
PLoS pathogens 2017 Sep;13(9):e1006580
PLoS pathogens 2017 Sep;13(9):e1006580
Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia.
Perea D, Guiu J, Hudry B, Konstantinidou C, Milona A, Hadjieconomou D, Carroll T, Hoyer N, Natarajan D, Kallijärvi J, Walker JA, Soba P, Thapar N, Burns AJ, Jensen KB, Miguel-Aliaga I
The EMBO journal 2017 Oct 16;36(20):3029-3045
The EMBO journal 2017 Oct 16;36(20):3029-3045
The PDGFRα-laminin B1-keratin 19 cascade drives tumor progression at the invasive front of human hepatocellular carcinoma.
Govaere O, Petz M, Wouters J, Vandewynckel YP, Scott EJ, Topal B, Nevens F, Verslype C, Anstee QM, Van Vlierberghe H, Mikulits W, Roskams T
Oncogene 2017 Nov 23;36(47):6605-6616
Oncogene 2017 Nov 23;36(47):6605-6616
Actin stress fiber organization promotes cell stiffening and proliferation of pre-invasive breast cancer cells.
Tavares S, Vieira AF, Taubenberger AV, Araújo M, Martins NP, Brás-Pereira C, Polónia A, Herbig M, Barreto C, Otto O, Cardoso J, Pereira-Leal JB, Guck J, Paredes J, Janody F
Nature communications 2017 May 16;8:15237
Nature communications 2017 May 16;8:15237
Intramembranous processing by γ-secretase regulates reverse signaling of ephrin-B2 in migration of microglia.
Kemmerling N, Wunderlich P, Theil S, Linnartz-Gerlach B, Hersch N, Hoffmann B, Heneka MT, de Strooper B, Neumann H, Walter J
Glia 2017 Jul;65(7):1103-1118
Glia 2017 Jul;65(7):1103-1118
Nucleoside diphosphate kinase B regulates angiogenic responses in the endothelium via caveolae formation and c-Src-mediated caveolin-1 phosphorylation.
Gross S, Devraj K, Feng Y, Macas J, Liebner S, Wieland T
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017 Jul;37(7):2471-2484
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2017 Jul;37(7):2471-2484
Phosphorylation-mediated activation of LDHA promotes cancer cell invasion and tumour metastasis.
Jin L, Chun J, Pan C, Alesi GN, Li D, Magliocca KR, Kang Y, Chen ZG, Shin DM, Khuri FR, Fan J, Kang S
Oncogene 2017 Jul 6;36(27):3797-3806
Oncogene 2017 Jul 6;36(27):3797-3806
Regulation of RhoA by STAT3 coordinates glial scar formation.
Renault-Mihara F, Mukaino M, Shinozaki M, Kumamaru H, Kawase S, Baudoux M, Ishibashi T, Kawabata S, Nishiyama Y, Sugai K, Yasutake K, Okada S, Nakamura M, Okano H
The Journal of cell biology 2017 Aug 7;216(8):2533-2550
The Journal of cell biology 2017 Aug 7;216(8):2533-2550
Tumor endothelial cells promote metastasis and cancer stem cell-like phenotype through elevated Epiregulin in esophageal cancer.
Sun L, Pan J, Yu L, Liu H, Shu X, Sun L, Lou J, Yang Z, Ran Y
American journal of cancer research 2016;6(10):2277-2288
American journal of cancer research 2016;6(10):2277-2288
Ischemia/reperfusion-induced alterations of enzymatic and signaling functions of the rat cardiac Na+/K+-ATPase: protection by ouabain preconditioning.
Belliard A, Gulati GK, Duan Q, Alves R, Brewer S, Madan N, Sottejeau Y, Wang X, Kalisz J, Pierre SV
Physiological reports 2016 Oct;4(19)
Physiological reports 2016 Oct;4(19)
Functional exploration of colorectal cancer genomes using Drosophila.
Bangi E, Murgia C, Teague AG, Sansom OJ, Cagan RL
Nature communications 2016 Nov 29;7:13615
Nature communications 2016 Nov 29;7:13615
GLP-1 inhibits VEGFA-mediated signaling in isolated human endothelial cells and VEGFA-induced dilation of rat mesenteric arteries.
Egholm C, Khammy MM, Dalsgaard T, Mazur A, Tritsaris K, Hansen AJ, Aalkjaer C, Dissing S
American journal of physiology. Heart and circulatory physiology 2016 Nov 1;311(5):H1214-H1224
American journal of physiology. Heart and circulatory physiology 2016 Nov 1;311(5):H1214-H1224
Na/K-ATPase signaling regulates collagen synthesis through microRNA-29b-3p in cardiac fibroblasts.
Drummond CA, Hill MC, Shi H, Fan X, Xie JX, Haller ST, Kennedy DJ, Liu J, Garrett MR, Xie Z, Cooper CJ, Shapiro JI, Tian J
Physiological genomics 2016 Mar;48(3):220-9
Physiological genomics 2016 Mar;48(3):220-9
Prolactin signaling through focal adhesion complexes is amplified by stiff extracellular matrices in breast cancer cells.
Barcus CE, Keely PJ, Eliceiri KW, Schuler LA
Oncotarget 2016 Jul 26;7(30):48093-48106
Oncotarget 2016 Jul 26;7(30):48093-48106
AMOTL1 Promotes Breast Cancer Progression and Is Antagonized by Merlin.
Couderc C, Boin A, Fuhrmann L, Vincent-Salomon A, Mandati V, Kieffer Y, Mechta-Grigoriou F, Del Maestro L, Chavrier P, Vallerand D, Brito I, Dubois T, De Koning L, Bouvard D, Louvard D, Gautreau A, Lallemand D
Neoplasia (New York, N.Y.) 2016 Jan;18(1):10-24
Neoplasia (New York, N.Y.) 2016 Jan;18(1):10-24
Fyn is an intermediate kinase that BDNF utilizes to promote oligodendrocyte myelination.
Peckham H, Giuffrida L, Wood R, Gonsalvez D, Ferner A, Kilpatrick TJ, Murray SS, Xiao J
Glia 2016 Feb;64(2):255-69
Glia 2016 Feb;64(2):255-69
Urokinase is a negative modulator of Egf-dependent proliferation and motility in the two breast cancer cell lines MCF-7 and MDA-MB-231.
Kozlova N, Samoylenko A, Drobot L, Kietzmann T
Molecular carcinogenesis 2016 Feb;55(2):170-81
Molecular carcinogenesis 2016 Feb;55(2):170-81
Drosophila Lung Cancer Models Identify Trametinib plus Statin as Candidate Therapeutic.
Levine BD, Cagan RL
Cell reports 2016 Feb 16;14(6):1477-1487
Cell reports 2016 Feb 16;14(6):1477-1487
Helicobacter pylori VacA, acting through receptor protein tyrosine phosphatase α, is crucial for CagA phosphorylation in human duodenum carcinoma cell line AZ-521.
Nakano M, Yahiro K, Yamasaki E, Kurazono H, Akada J, Yamaoka Y, Niidome T, Hatakeyama M, Suzuki H, Yamamoto T, Moss J, Isomoto H, Hirayama T
Disease models & mechanisms 2016 Dec 1;9(12):1473-1481
Disease models & mechanisms 2016 Dec 1;9(12):1473-1481
FMN2 Makes Perinuclear Actin to Protect Nuclei during Confined Migration and Promote Metastasis.
Skau CT, Fischer RS, Gurel P, Thiam HR, Tubbs A, Baird MA, Davidson MW, Piel M, Alushin GM, Nussenzweig A, Steeg PS, Waterman CM
Cell 2016 Dec 1;167(6):1571-1585.e18
Cell 2016 Dec 1;167(6):1571-1585.e18
GIV/Girdin (Gα-interacting, Vesicle-associated Protein/Girdin) Creates a Positive Feedback Loop That Potentiates Outside-in Integrin Signaling in Cancer Cells.
Leyme A, Marivin A, Garcia-Marcos M
The Journal of biological chemistry 2016 Apr 8;291(15):8269-82
The Journal of biological chemistry 2016 Apr 8;291(15):8269-82
Aurora A drives early signalling and vesicle dynamics during T-cell activation.
Blas-Rus N, Bustos-Morán E, Pérez de Castro I, de Cárcer G, Borroto A, Camafeita E, Jorge I, Vázquez J, Alarcón B, Malumbres M, Martín-Cófreces NB, Sánchez-Madrid F
Nature communications 2016 Apr 19;7:11389
Nature communications 2016 Apr 19;7:11389
α-Actinin-4 enhances colorectal cancer cell invasion by suppressing focal adhesion maturation.
Fukumoto M, Kurisu S, Yamada T, Takenawa T
PloS one 2015;10(4):e0120616
PloS one 2015;10(4):e0120616
TGFβ signaling in myeloid cells regulates mammary carcinoma cell invasion through fibroblast interactions.
Shaw AK, Pickup MW, Chytil A, Aakre M, Owens P, Moses HL, Novitskiy SV
PloS one 2015;10(1):e0117908
PloS one 2015;10(1):e0117908
Dense collagen-I matrices enhance pro-tumorigenic estrogen-prolactin crosstalk in MCF-7 and T47D breast cancer cells.
Barcus CE, Holt EC, Keely PJ, Eliceiri KW, Schuler LA
PloS one 2015;10(1):e0116891
PloS one 2015;10(1):e0116891
Rip2 modifies VEGF-induced signalling and vascular permeability in myocardial ischaemia.
Andersson L, Scharin Täng M, Lundqvist A, Lindbom M, Mardani I, Fogelstrand P, Shahrouki P, Redfors B, Omerovic E, Levin M, Borén J, Levin MC
Cardiovascular research 2015 Sep 1;107(4):478-86
Cardiovascular research 2015 Sep 1;107(4):478-86
Fatty acylated caveolin-2 is a substrate of insulin receptor tyrosine kinase for insulin receptor substrate-1-directed signaling activation.
Kwon H, Lee J, Jeong K, Jang D, Pak Y
Biochimica et biophysica acta 2015 May;1853(5):1022-34
Biochimica et biophysica acta 2015 May;1853(5):1022-34
Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland.
Cunnick JM, Kim S, Hadsell J, Collins S, Cerra C, Reiser P, Flynn DC, Cho Y
Oncogene 2015 May 14;34(20):2640-9
Oncogene 2015 May 14;34(20):2640-9
Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.
Girotti MR, Lopes F, Preece N, Niculescu-Duvaz D, Zambon A, Davies L, Whittaker S, Saturno G, Viros A, Pedersen M, Suijkerbuijk BM, Menard D, McLeary R, Johnson L, Fish L, Ejiama S, Sanchez-Laorden B, Hohloch J, Carragher N, Macleod K, Ashton G, Marusiak AA, Fusi A, Brognard J, Frame M, Lorigan P, Marais R, Springer C
Cancer cell 2015 Jan 12;27(1):85-96
Cancer cell 2015 Jan 12;27(1):85-96
SLAP displays tumour suppressor functions in colorectal cancer via destabilization of the SRC substrate EPHA2.
Naudin C, Sirvent A, Leroy C, Larive R, Simon V, Pannequin J, Bourgaux JF, Pierre J, Robert B, Hollande F, Roche S
Nature communications 2014;5:3159
Nature communications 2014;5:3159
Dihydrotestosterone potentiates EGF-induced ERK activation by inducing SRC in fetal lung fibroblasts.
Lee MK, Smith SM, Murray S, Pham LD, Minoo P, Nielsen HC
American journal of respiratory cell and molecular biology 2014 Jul;51(1):114-24
American journal of respiratory cell and molecular biology 2014 Jul;51(1):114-24
c-Src drives intestinal regeneration and transformation.
Cordero JB, Ridgway RA, Valeri N, Nixon C, Frame MC, Muller WJ, Vidal M, Sansom OJ
The EMBO journal 2014 Jul 1;33(13):1474-91
The EMBO journal 2014 Jul 1;33(13):1474-91
EphA/ephrin A reverse signaling promotes the migration of cortical interneurons from the medial ganglionic eminence.
Steinecke A, Gampe C, Zimmer G, Rudolph J, Bolz J
Development (Cambridge, England) 2014 Jan;141(2):460-71
Development (Cambridge, England) 2014 Jan;141(2):460-71
c-Yes tyrosine kinase is a potent suppressor of ES cell differentiation and antagonizes the actions of its closest phylogenetic relative, c-Src.
Zhang X, Meyn MA 3rd, Smithgall TE
ACS chemical biology 2014 Jan 17;9(1):139-46
ACS chemical biology 2014 Jan 17;9(1):139-46
Ouabain induces endocytosis and degradation of tight junction proteins through ERK1/2-dependent pathways.
Rincon-Heredia R, Flores-Benitez D, Flores-Maldonado C, Bonilla-Delgado J, García-Hernández V, Verdejo-Torres O, Castillo AM, Larré I, Poot-Hernández AC, Franco M, Gariglio P, Reyes JL, Contreras RG
Experimental cell research 2014 Jan 1;320(1):108-18
Experimental cell research 2014 Jan 1;320(1):108-18
Dasatinib (BMS-35482) interacts synergistically with docetaxel, gemcitabine, topotecan, and doxorubicin in ovarian cancer cells with high SRC pathway activation and protein expression.
Secord AA, Teoh D, Jia J, Nixon AB, Grace L, Adams DJ, Murphy SK
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2014 Feb;24(2):218-25
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 2014 Feb;24(2):218-25
α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.
Basu S, Rajakaruna S, De Arcangelis A, Zhang L, Georges-Labouesse E, Menko AS
The Journal of biological chemistry 2014 Feb 14;289(7):3842-55
The Journal of biological chemistry 2014 Feb 14;289(7):3842-55
Activation of Src and release of intracellular calcium by phosphatidic acid during Xenopus laevis fertilization.
Bates RC, Fees CP, Holland WL, Winger CC, Batbayar K, Ancar R, Bergren T, Petcoff D, Stith BJ
Developmental biology 2014 Feb 1;386(1):165-80
Developmental biology 2014 Feb 1;386(1):165-80
The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis.
Mahbub Hasan AK, Hashimoto A, Maekawa Y, Matsumoto T, Kushima S, Ijiri TW, Fukami Y, Sato K
Development (Cambridge, England) 2014 Apr;141(8):1705-14
Development (Cambridge, England) 2014 Apr;141(8):1705-14
Dissecting motility signaling through activation of specific Src-effector complexes.
Karginov AV, Tsygankov D, Berginski M, Chu PH, Trudeau ED, Yi JJ, Gomez S, Elston TC, Hahn KM
Nature chemical biology 2014 Apr;10(4):286-90
Nature chemical biology 2014 Apr;10(4):286-90
Digitalis-induced cell signaling by the sodium pump: on the relation of Src to Na(+)/K(+)-ATPase.
Gable ME, Abdallah SL, Najjar SM, Liu L, Askari A
Biochemical and biophysical research communications 2014 Apr 18;446(4):1151-4
Biochemical and biophysical research communications 2014 Apr 18;446(4):1151-4
Identification of novel molecular regulators of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in breast cancer cells by RNAi screening.
Garimella SV, Gehlhaus K, Dine JL, Pitt JJ, Grandin M, Chakka S, Nau MM, Caplen NJ, Lipkowitz S
Breast cancer research : BCR 2014 Apr 17;16(2):R41
Breast cancer research : BCR 2014 Apr 17;16(2):R41
Novel role of MDA-9/syntenin in regulating urothelial cell proliferation by modulating EGFR signaling.
Dasgupta S, Menezes ME, Das SK, Emdad L, Janjic A, Bhatia S, Mukhopadhyay ND, Shao C, Sarkar D, Fisher PB
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Sep 1;19(17):4621-33
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Sep 1;19(17):4621-33
Phosphatidylinositol phosphate 5-kinase Iγi2 in association with Src controls anchorage-independent growth of tumor cells.
Thapa N, Choi S, Hedman A, Tan X, Anderson RA
The Journal of biological chemistry 2013 Nov 29;288(48):34707-18
The Journal of biological chemistry 2013 Nov 29;288(48):34707-18
Tetraspanin CD63 promotes vascular endothelial growth factor receptor 2-β1 integrin complex formation, thereby regulating activation and downstream signaling in endothelial cells in vitro and in vivo.
Tugues S, Honjo S, König C, Padhan N, Kroon J, Gualandi L, Li X, Barkefors I, Thijssen VL, Griffioen AW, Claesson-Welsh L
The Journal of biological chemistry 2013 Jun 28;288(26):19060-71
The Journal of biological chemistry 2013 Jun 28;288(26):19060-71
Inhibiting EGF receptor or SRC family kinase signaling overcomes BRAF inhibitor resistance in melanoma.
Girotti MR, Pedersen M, Sanchez-Laorden B, Viros A, Turajlic S, Niculescu-Duvaz D, Zambon A, Sinclair J, Hayes A, Gore M, Lorigan P, Springer C, Larkin J, Jorgensen C, Marais R
Cancer discovery 2013 Feb;3(2):158-67
Cancer discovery 2013 Feb;3(2):158-67
Nef alleles from all major HIV-1 clades activate Src-family kinases and enhance HIV-1 replication in an inhibitor-sensitive manner.
Narute PS, Smithgall TE
PloS one 2012;7(2):e32561
PloS one 2012;7(2):e32561
Na,K-ATPase activity modulates Src activation: a role for ATP/ADP ratio.
Weigand KM, Swarts HG, Fedosova NU, Russel FG, Koenderink JB
Biochimica et biophysica acta 2012 May;1818(5):1269-73
Biochimica et biophysica acta 2012 May;1818(5):1269-73
Drosophila Src regulates anisotropic apical surface growth to control epithelial tube size.
Nelson KS, Khan Z, Molnár I, Mihály J, Kaschube M, Beitel GJ
Nature cell biology 2012 Mar 25;14(5):518-25
Nature cell biology 2012 Mar 25;14(5):518-25
Biophysical stimulation induces demyelination via an integrin-dependent mechanism.
Lin MY, Frieboes LS, Forootan M, Palispis WA, Mozaffar T, Jafari M, Steward O, Gall CM, Gupta R
Annals of neurology 2012 Jul;72(1):112-23
Annals of neurology 2012 Jul;72(1):112-23
Stat3 is a positive regulator of gap junctional intercellular communication in cultured, human lung carcinoma cells.
Geletu M, Arulanandam R, Greer S, Trotman-Grant A, Tomai E, Raptis L
BMC cancer 2012 Dec 18;12:605
BMC cancer 2012 Dec 18;12:605
The CXCL12/CXCR4 axis promotes ligand-independent activation of the androgen receptor.
Kasina S, Macoska JA
Molecular and cellular endocrinology 2012 Apr 4;351(2):249-63
Molecular and cellular endocrinology 2012 Apr 4;351(2):249-63
Na/K-ATPase mimetic pNaKtide peptide inhibits the growth of human cancer cells.
Li Z, Zhang Z, Xie JX, Li X, Tian J, Cai T, Cui H, Ding H, Shapiro JI, Xie Z
The Journal of biological chemistry 2011 Sep 16;286(37):32394-403
The Journal of biological chemistry 2011 Sep 16;286(37):32394-403
VEGF mediates commissural axon chemoattraction through its receptor Flk1.
Ruiz de Almodovar C, Fabre PJ, Knevels E, Coulon C, Segura I, Haddick PC, Aerts L, Delattin N, Strasser G, Oh WJ, Lange C, Vinckier S, Haigh J, Fouquet C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F, Carmeliet P
Neuron 2011 Jun 9;70(5):966-78
Neuron 2011 Jun 9;70(5):966-78
cAMP-dependent protein kinase activated Fyn in spinal dorsal horn to regulate NMDA receptor function during inflammatory pain.
Yang HB, Yang X, Cao J, Li S, Liu YN, Suo ZW, Cui HB, Guo Z, Hu XD
Journal of neurochemistry 2011 Jan;116(1):93-104
Journal of neurochemistry 2011 Jan;116(1):93-104
zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation.
Chen SY, Chiu LY, Maa MC, Wang JS, Chien CL, Lin WW
Autophagy 2011 Feb;7(2):217-28
Autophagy 2011 Feb;7(2):217-28
zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation.
Chen SY, Chiu LY, Maa MC, Wang JS, Chien CL, Lin WW
Autophagy 2011 Feb;7(2):217-28
Autophagy 2011 Feb;7(2):217-28
Androgens activate mitogen-activated protein kinase via epidermal growth factor receptor/insulin-like growth factor 1 receptor in the mouse PC-1 cell line.
Hamzeh M, Robaire B
The Journal of endocrinology 2011 Apr;209(1):55-64
The Journal of endocrinology 2011 Apr;209(1):55-64
Integrin activation promotes axon growth on inhibitory chondroitin sulfate proteoglycans by enhancing integrin signaling.
Tan CL, Kwok JC, Patani R, Ffrench-Constant C, Chandran S, Fawcett JW
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Apr 27;31(17):6289-95
The Journal of neuroscience : the official journal of the Society for Neuroscience 2011 Apr 27;31(17):6289-95
Oncostatin M promotes STAT3 activation, VEGF production, and invasion in osteosarcoma cell lines.
Fossey SL, Bear MD, Kisseberth WC, Pennell M, London CA
BMC cancer 2011 Apr 11;11:125
BMC cancer 2011 Apr 11;11:125
SHP2 mediates the localized activation of Fyn downstream of the α6β4 integrin to promote carcinoma invasion.
Yang X, Dutta U, Shaw LM
Molecular and cellular biology 2010 Nov;30(22):5306-17
Molecular and cellular biology 2010 Nov;30(22):5306-17
Inhibition of focal adhesion kinase and src increases detachment and apoptosis in human neuroblastoma cell lines.
Beierle EA, Ma X, Trujillo A, Kurenova EV, Cance WG, Golubovskaya VM
Molecular carcinogenesis 2010 Mar;49(3):224-34
Molecular carcinogenesis 2010 Mar;49(3):224-34
Prolactin enhances insulin-like growth factor I receptor phosphorylation by decreasing its association with the tyrosine phosphatase SHP-2 in MCF-7 breast cancer cells.
Carver KC, Piazza TM, Schuler LA
The Journal of biological chemistry 2010 Mar 12;285(11):8003-12
The Journal of biological chemistry 2010 Mar 12;285(11):8003-12
The simian virus 40 large tumor antigen activates cSrc and requires cSrc for full neoplastic transformation.
Arulanandam R, Geletu M, Raptis L
Anticancer research 2010 Jan;30(1):47-53
Anticancer research 2010 Jan;30(1):47-53
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Akbulut T, Regner KR, Roman RJ, Avner ED, Falck JR, Park F
American journal of physiology. Renal physiology 2009 Sep;297(3):F662-70
American journal of physiology. Renal physiology 2009 Sep;297(3):F662-70
Complete focal adhesion kinase deficiency in the mammary gland causes ductal dilation and aberrant branching morphogenesis through defects in Rho kinase-dependent cell contractility.
van Miltenburg MH, Lalai R, de Bont H, van Waaij E, Beggs H, Danen EH, van de Water B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Oct;23(10):3482-93
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009 Oct;23(10):3482-93
HCT116 cells deficient in p21(Waf1) are hypersensitive to tyrosine kinase inhibitors and adriamycin through a mechanism unrelated to p21 and dependent on p53.
Ferrandiz N, Martin-Perez J, Blanco R, Donertas D, Weber A, Eilers M, Dotto P, Delgado MD, Leon J
DNA repair 2009 Mar 1;8(3):390-9
DNA repair 2009 Mar 1;8(3):390-9
Interstitial fluid flow intensity modulates endothelial sprouting in restricted Src-activated cell clusters during capillary morphogenesis.
Hernández Vera R, Genové E, Alvarez L, Borrós S, Kamm R, Lauffenburger D, Semino CE
Tissue engineering. Part A 2009 Jan;15(1):175-85
Tissue engineering. Part A 2009 Jan;15(1):175-85
ADAM-mediated amphiregulin shedding and EGFR transactivation.
Kasina S, Scherle PA, Hall CL, Macoska JA
Cell proliferation 2009 Dec;42(6):799-812
Cell proliferation 2009 Dec;42(6):799-812
The involvement of the tyrosine kinase c-Src in the regulation of reactive oxygen species generation mediated by NADPH oxidase-1.
Gianni D, Bohl B, Courtneidge SA, Bokoch GM
Molecular biology of the cell 2008 Jul;19(7):2984-94
Molecular biology of the cell 2008 Jul;19(7):2984-94
Src inhibition ameliorates polycystic kidney disease.
Sweeney WE Jr, von Vigier RO, Frost P, Avner ED
Journal of the American Society of Nephrology : JASN 2008 Jul;19(7):1331-41
Journal of the American Society of Nephrology : JASN 2008 Jul;19(7):1331-41
Sphingosine 1-phosphate induces platelet/endothelial cell adhesion molecule-1 phosphorylation in human endothelial cells through cSrc and Fyn.
Huang YT, Chen SU, Chou CH, Lee H
Cellular signalling 2008 Aug;20(8):1521-7
Cellular signalling 2008 Aug;20(8):1521-7
Dual function of Src in the maintenance of adherens junctions during tracheal epithelial morphogenesis.
Shindo M, Wada H, Kaido M, Tateno M, Aigaki T, Tsuda L, Hayashi S
Development (Cambridge, England) 2008 Apr;135(7):1355-64
Development (Cambridge, England) 2008 Apr;135(7):1355-64
Platelet integrin adhesive functions and signaling.
Prévost N, Kato H, Bodin L, Shattil SJ
Methods in enzymology 2007;426:103-15
Methods in enzymology 2007;426:103-15
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.
Allingham MJ, van Buul JD, Burridge K
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):4053-64
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):4053-64
ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.
Allingham MJ, van Buul JD, Burridge K
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):4053-64
Journal of immunology (Baltimore, Md. : 1950) 2007 Sep 15;179(6):4053-64
Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases.
Hu X, Dang Y, Tenney K, Crews P, Tsai CW, Sixt KM, Cole PA, Liu JO
Chemistry & biology 2007 Jul;14(7):764-74
Chemistry & biology 2007 Jul;14(7):764-74
Analyzing FAK and Pyk2 in early integrin signaling events.
Bernard-Trifilo JA, Lim ST, Hou S, Schlaepfer DD, Ilic D
Current protocols in cell biology 2006 Apr;Chapter 14:Unit 14.7
Current protocols in cell biology 2006 Apr;Chapter 14:Unit 14.7
A mechanosensory complex that mediates the endothelial cell response to fluid shear stress.
Tzima E, Irani-Tehrani M, Kiosses WB, Dejana E, Schultz DA, Engelhardt B, Cao G, DeLisser H, Schwartz MA
Nature 2005 Sep 15;437(7057):426-31
Nature 2005 Sep 15;437(7057):426-31
A requirement for CD45 distinguishes Ly49D-mediated cytokine and chemokine production from killing in primary natural killer cells.
Huntington ND, Xu Y, Nutt SL, Tarlinton DM
The Journal of experimental medicine 2005 May 2;201(9):1421-33
The Journal of experimental medicine 2005 May 2;201(9):1421-33
(alpha)v(beta)3 integrins and Pyk2 mediate insulin-like growth factor I activation of Src and mitogen-activated protein kinase in 3T3-L1 cells.
Sekimoto H, Eipper-Mains J, Pond-Tor S, Boney CM
Molecular endocrinology (Baltimore, Md.) 2005 Jul;19(7):1859-67
Molecular endocrinology (Baltimore, Md.) 2005 Jul;19(7):1859-67
Reelin activates SRC family tyrosine kinases in neurons.
Bock HH, Herz J
Current biology : CB 2003 Jan 8;13(1):18-26
Current biology : CB 2003 Jan 8;13(1):18-26
Reelin activates SRC family tyrosine kinases in neurons.
Bock HH, Herz J
Current biology : CB 2003 Jan 8;13(1):18-26
Current biology : CB 2003 Jan 8;13(1):18-26
Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression.
Morel JC, Park CC, Zhu K, Kumar P, Ruth JH, Koch AE
The Journal of biological chemistry 2002 Sep 20;277(38):34679-91
The Journal of biological chemistry 2002 Sep 20;277(38):34679-91
The distinct capacity of Fyn and Lck to phosphorylate Sam68 in T cells is essentially governed by SH3/SH2-catalytic domain linker interactions.
Feuillet V, Semichon M, Restouin A, Harriague J, Janzen J, Magee A, Collette Y, Bismuth G
Oncogene 2002 Oct 17;21(47):7205-13
Oncogene 2002 Oct 17;21(47):7205-13
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
Cary LA, Klinghoffer RA, Sachsenmaier C, Cooper JA
Molecular and cellular biology 2002 Apr;22(8):2427-40
Molecular and cellular biology 2002 Apr;22(8):2427-40
SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.
Cary LA, Klinghoffer RA, Sachsenmaier C, Cooper JA
Molecular and cellular biology 2002 Apr;22(8):2427-40
Molecular and cellular biology 2002 Apr;22(8):2427-40
CD44 interaction with c-Src kinase promotes cortactin-mediated cytoskeleton function and hyaluronic acid-dependent ovarian tumor cell migration.
Bourguignon LY, Zhu H, Shao L, Chen YW
The Journal of biological chemistry 2001 Mar 9;276(10):7327-36
The Journal of biological chemistry 2001 Mar 9;276(10):7327-36
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Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Western Blot analysis of Src (pY419) Rabbit polyclonal Antibody - Purified
Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- Immunohistochemistry analysis of SRC showing staining in the cytoplasm and membrane of paraffin-embedded human colon carcinoma (right) compared to a negative control without primary antibody (left). To expose target proteins, antigen retrieval was performed using 10mM sodium citrate (pH 6.0), microwaved for 8-15 min. Following antigen retrieval, tissues were blocked in 3% H2O2-methanol for 15 min at room temperature, washed with ddH2O and PBS, and then probed with a SRC (Product # 44-660G) diluted in 3% BSA-PBS at a dilution of 1:20 overnight at 4°C in a humidified chamber. Tissues were washed extensively in PBST and detection was performed using an HRP-conjugated secondary antibody followed by colorimetric detection using a DAB kit. Tissues were counterstained with hematoxylin and dehydrated with ethanol and xylene to prep for mounting.
Supportive validation
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- Invitrogen Antibodies (provider)
- Main image
- Experimental details
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- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL
- Submitted by
- Invitrogen Antibodies (provider)
- Main image
- Experimental details
- NULL