SRC

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Description

SRC proto-oncogene, non-receptor tyrosine kinase

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Plasma membrane, Cell Junctions, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

20:q11.23 (37344685 - 37406050)

Ensembl ID

ENSG00000197122  (ver. 103.38)

Orthologs

Mouse Src: ENSMUSG00000027646

UniProt

P12931

neXtProt

NX_P12931

Human splice variants
Mouse splice variants