SRC

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Description

SRC proto-oncogene, non-receptor tyrosine kinase

Protein family

Cancer-related genes, Cytoskeleton related proteins, Disease related genes, Enzymes, FDA approved drug targets, Mapped to UniProt SWISS-PROT, Plasma proteins, Predicted intracellular proteins, Protein evidence (Ezkurdia et al 2014), Protein evidence (Kim et al 2014)

Chromosome

20:q11.23 (37344685 - 37406050)

Ensembl ID

ENSG00000197122  (ver. 84.38)

Orthologs

Mouse Src: ENSMUSG00000027646

UniProt

P12931

neXtProt

NX_P12931

Human splice variants
Mouse splice variants