Antibody data
- Antibody Data
- Antigen structure
- References [2]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- 312802 - Provider product page
- Provider
- BioLegend
- Proper citation
- BioLegend Cat#312802, RRID:AB_314951
- Product name
- Purified anti-human CD284 (TLR4)
- Antibody type
- Monoclonal
- Antigen
- Ba/F3 cell line expressing human TLR4
- Description
- Toll-like receptors are type I transmembrane signaling receptors. They are primordial pathogen-recognition proteins that function as sentinels for the innate immune system. TLR4, also known as CD284, is a 110 kD protein which is expressed on monocytes/macrophages, endothelial cells, and at low levels on B cells and granulocytes. In association with a secretory molecule, MD2, TLR4 has been recognized as critical for host recognition of bacterial LPS. HTA125 antibody is useful for flow cytometric analysis and is able to block LPS-induced cytokine production.
- Reactivity
- Human, Guinea Pig, Simian
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 µg
- Concentration
- 0.5 mg/ml
- Storage
- The antibody solution should be stored undiluted at 4°C.
Submitted references Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells.
High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells.
Bhattacharyya S, Gill R, Chen ML, Zhang F, Linhardt RJ, Dudeja PK, Tobacman JK
The Journal of biological chemistry 2008 Apr 18;283(16):10550-8
The Journal of biological chemistry 2008 Apr 18;283(16):10550-8
High-mobility group box 1 activates integrin-dependent homing of endothelial progenitor cells.
Chavakis E, Hain A, Vinci M, Carmona G, Bianchi ME, Vajkoczy P, Zeiher AM, Chavakis T, Dimmeler S
Circulation research 2007 Feb 2;100(2):204-12
Circulation research 2007 Feb 2;100(2):204-12
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Supportive validation
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- BioLegend (provider)
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- Experimental details
- Human peripheral blood monocytes stained with HTA125 PE
- Conjugate
- Unconjugated