Tissue expression
Cell line expression

TLR4

gene product
ARMD10, CD284, hToll, TLR-4 
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19). This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
More gene data

Featured antibodies

Antibodies

 

Filters

Application

Validation method

Reference

Provider

Host

Reactivity

Antibody type

Antigen sequence

Conjugate

Epitope

Antibody

  or   Clear
Enhanced validation
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
1910 antibodies from 50 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeWBELICCIPIHCFC
Novus Biologicals
203 antibodies
GeneTex
22 antibodies
R&D Systems
33 antibodies
antibodies-online
609 antibodies
Acris Antibodies GmbH
52 antibodies
Invitrogen Antibodies
70 antibodies
Proteintech Group
3 antibodies
Enzo Life Sciences
9 antibodies
LifeSpan BioSciences, Inc.
291 antibodies
Abnova Corporation
26 antibodies
OriGene
45 antibodies
Affinity Biosciences
2 antibodies
Signalway Antibody LLC
2 antibodies
HUABIO Research
1 antibody
BioLegend
12 antibodies
Biorbyt
89 antibodies
Arigo
3 antibodies
Boster Biological Technology
3 antibodies
NovoPro Bioscience Inc.
8 antibodies
Cusabio Biotech Co., Ltd
7 antibodies
Wuhan Fine Biotech Co., Ltd.
2 antibodies
ProSci
13 antibodies
ABEOMICS Inc.
10 antibodies
Aviva Systems Biology
15 antibodies
Abgent
10 antibodies
NSJ Bioreagents
3 antibodies
Bioworld Technology, Inc
1 antibody
Abbkine Scientific Co.Ltd.
2 antibodies
RabMAbs
1 antibody
Creative Diagnostics
23 antibodies
MyBioSource
23 antibodies
MilliporeSigma / Merck KGaA
3 antibodies
Rockland Immunochemicals, Inc.
7 antibodies
Creative Biolabs
77 antibodies
FabGennix
3 antibodies
BioLegend (formerly Covance Antibody Products)
2 antibodies
Atlas Antibodies
1 antibody
Miltenyi Biotec
8 antibodies
Abbexa
32 antibodies
Leading Biology
12 antibodies
RayBiotech, Inc.
9 antibodies
eBioscience, An Affymetrix Company
18 antibodies
GenWay
16 antibodies
EMD Millipore
2 antibodies
Abbiotec
1 antibody
Abiocode, Inc.
1 antibody
Cell Signaling Technology, Inc
1 antibody
United States Biological
77 antibodies
Exalpha Biologicals, Inc.
1 antibody