Antibody data
- Antibody Data
- Antigen structure
- References [75]
- Comments [0]
- Validations
- Flow cytometry [1]
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- Product number
- FAB357P-100 - Provider product page
- Provider
- R&D Systems
- Product name
- Human VEGFR2/KDR/Flk-1 PE-conjugated Antibody
- Antibody type
- Monoclonal
- Description
- Protein A or G purified from hybridoma culture supernatant. Detects human VEGF R2/KDR/Flk-1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) VEGF R1, rhVEGF R3 or recombinant mouse VEGF R2 is observed.
- Reactivity
- Human
- Host
- Mouse
- Antigen sequence
P35968
- Isotype
- IgG
- Antibody clone number
- 89106
- Vial size
- 100 Tests
- Storage
- Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
Submitted references Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies.
Effect of intensive multifactorial treatment on vascular progenitor cells in hypertensive patients.
Linking cell function with perfusion: insights from the transcatheter delivery of bone marrow-derived CD133+ cells in ischemic refractory cardiomyopathy trial (RECARDIO).
Anti-Angiogenic miR-222, miR-195, and miR-21a Plasma Levels in T1DM Are Improved by Metformin Therapy, Thus Elucidating Its Cardioprotective Effect: The MERIT Study.
Putative mechanisms Underlying Myocardial infarction onset and Emotions (PUME): a randomised controlled study protocol.
Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon therapy.
Preparation of iPS cell-derived CD31+ endothelial cells using three-dimensional suspension culture.
Hydrogen Sulfide-Preconditioning of Human Endothelial Progenitor Cells Transplantation Improves Re-Endothelialization in Nude Mice with Carotid Artery Injury.
Sex Differences in Circulating Progenitor Cells.
A quantitative method for screening and identifying molecular targets for nanomedicine.
The Blebbishield Emergency Program Overrides Chromosomal Instability and Phagocytosis Checkpoints in Cancer Stem Cells.
VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells.
Increased serum levels of fractalkine and mobilisation of CD34+CD45- endothelial progenitor cells in systemic sclerosis.
Circulating microparticle subpopulations in systemic lupus erythematosus are affected by disease activity.
Effects of a New Nutraceutical Formulation (Berberine, Red Yeast Rice and Chitosan) on Non-HDL Cholesterol Levels in Individuals with Dyslipidemia: Results from a Randomized, Double Blind, Placebo-Controlled Study.
Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome.
Cell therapy in critical limb ischemia: A comprehensive analysis of two cell therapy products.
Vildagliptin, but not glibenclamide, increases circulating endothelial progenitor cell number: a 12-month randomized controlled trial in patients with type 2 diabetes.
BMP4/Id2 signaling pathway is a novel therapeutic target for late outgrowth endothelial progenitor cell-mediated endothelial injury repair.
Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.
MicroRNA-134 Contributes to Glucose-Induced Endothelial Cell Dysfunction and This Effect Can Be Reversed by Far-Infrared Irradiation.
Mycobacterium tuberculosis exploits the formation of new blood vessels for its dissemination.
Endothelial cell colony forming units derived from malignant breast diseases are resistant to tumor necrosis factor-α-induced apoptosis.
Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.
Dysregulation of ossification-related miRNAs in circulating osteogenic progenitor cells obtained from patients with aortic stenosis.
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
Generation of articular chondrocytes from human pluripotent stem cells.
The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study.
BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth.
Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.
The relationship between endothelial progenitor cell populations and epicardial and microvascular coronary disease-a cellular, angiographic and physiologic study.
Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth.
IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.
Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R.
Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer.
Efficiency of statin treatment on EPC recruitment depends on baseline EPC titer and does not improve angiographic outcome in coronary artery disease patients treated with the Genous stent.
Laminin promotes vascular network formation in 3D in vitro collagen scaffolds by regulating VEGF uptake.
Migratory activity of circulating mononuclear cells is associated with cardiovascular mortality in type 2 diabetic patients with critical limb ischemia.
The dipeptidyl peptidase-4 inhibitor saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients.
Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells.
Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
The synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrence.
Circulating endothelial progenitor cells decrease in infants with bronchopulmonary dysplasia and increase after inhaled nitric oxide.
Functional and molecular characterization of ex vivo cultured epiretinal membrane cells from human proliferative diabetic retinopathy.
CXCR4 positive and angiogenic monocytes in myocardial infarction.
Diabetes impairs stem cell and proangiogenic cell mobilization in humans.
GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC.
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free medium.
Successful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression.
Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis.
Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.
Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man.
Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.
VEGFR2 is selectively expressed by FOXP3high CD4+ Treg.
Comparison of endothelial progenitor cell function in type 2 diabetes with good and poor glycemic control.
Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation.
Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells.
Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy.
Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation.
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Alternative splicing of vasohibin-1 generates an inhibitor of endothelial cell proliferation, migration, and capillary tube formation.
Late outgrowth endothelial progenitor cells in patients with age-related macular degeneration.
Microtubule-targeted drugs inhibit VEGF receptor-2 expression by both transcriptional and post-transcriptional mechanisms.
Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression.
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor.
Increased circulating endothelial progenitor cells in septic patients: correlation with survival.
VEGFR2 expressing circulating (progenitor) cell populations in volunteers and cancer patients.
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A.
Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system.
Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages.
Expansion of human SCID-repopulating cells under hypoxic conditions.
Mair B, Tomic J, Masud SN, Tonge P, Weiss A, Usaj M, Tong AHY, Kwan JJ, Brown KR, Titus E, Atkins M, Chan KSK, Munsie L, Habsid A, Han H, Kennedy M, Cohen B, Keller G, Moffat J
Cell reports 2019 Apr 9;27(2):599-615.e12
Cell reports 2019 Apr 9;27(2):599-615.e12
Effect of intensive multifactorial treatment on vascular progenitor cells in hypertensive patients.
Maroun-Eid C, Ortega-Hernández A, Modrego J, Abad-Cardiel M, García-Donaire JA, Reinares L, Martell-Claros N, Gómez-Garre D
PloS one 2018;13(1):e0190494
PloS one 2018;13(1):e0190494
Linking cell function with perfusion: insights from the transcatheter delivery of bone marrow-derived CD133+ cells in ischemic refractory cardiomyopathy trial (RECARDIO).
Bassetti B, Carbucicchio C, Catto V, Gambini E, Rurali E, Bestetti A, Gaipa G, Belotti D, Celeste F, Parma M, Righetti S, Biava L, Arosio M, Bonomi A, Agostoni P, Scacciatella P, Achilli F, Pompilio G
Stem cell research & therapy 2018 Sep 14;9(1):235
Stem cell research & therapy 2018 Sep 14;9(1):235
Anti-Angiogenic miR-222, miR-195, and miR-21a Plasma Levels in T1DM Are Improved by Metformin Therapy, Thus Elucidating Its Cardioprotective Effect: The MERIT Study.
Ahmed FW, Bakhashab S, Bastaman IT, Crossland RE, Glanville M, Weaver JU
International journal of molecular sciences 2018 Oct 19;19(10)
International journal of molecular sciences 2018 Oct 19;19(10)
Putative mechanisms Underlying Myocardial infarction onset and Emotions (PUME): a randomised controlled study protocol.
Ensari I, Burg MM, Diaz KM, Fu J, Duran AT, Suls JM, Sumner JA, Monane R, Julian JE, Zhao S, Chaplin WF, Shimbo D
BMJ open 2018 May 31;8(5):e020525
BMJ open 2018 May 31;8(5):e020525
Endothelial cell functions impaired by interferon in vitro: Insights into the molecular mechanism of thrombotic microangiopathy associated with interferon therapy.
Jia H, Thelwell C, Dilger P, Bird C, Daniels S, Wadhwa M
Thrombosis research 2018 Mar;163:105-116
Thrombosis research 2018 Mar;163:105-116
Preparation of iPS cell-derived CD31+ endothelial cells using three-dimensional suspension culture.
Masuda S, Matsuura K, Shimizu T
Regenerative therapy 2018 Dec;9:1-9
Regenerative therapy 2018 Dec;9:1-9
Hydrogen Sulfide-Preconditioning of Human Endothelial Progenitor Cells Transplantation Improves Re-Endothelialization in Nude Mice with Carotid Artery Injury.
Ke X, Zou J, Hu Q, Wang X, Hu C, Yang R, Liang J, Shu X, Nie R, Peng C
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(1):308-319
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(1):308-319
Sex Differences in Circulating Progenitor Cells.
Topel ML, Hayek SS, Ko YA, Sandesara PB, Samman Tahhan A, Hesaroieh I, Mahar E, Martin GS, Waller EK, Quyyumi AA
Journal of the American Heart Association 2017 Oct 3;6(10)
Journal of the American Heart Association 2017 Oct 3;6(10)
A quantitative method for screening and identifying molecular targets for nanomedicine.
Guo P, Yang J, Bielenberg DR, Dillon D, Zurakowski D, Moses MA, Auguste DT
Journal of controlled release : official journal of the Controlled Release Society 2017 Oct 10;263:57-67
Journal of controlled release : official journal of the Controlled Release Society 2017 Oct 10;263:57-67
The Blebbishield Emergency Program Overrides Chromosomal Instability and Phagocytosis Checkpoints in Cancer Stem Cells.
Jinesh GG, Kamat AM
Cancer research 2017 Nov 15;77(22):6144-6156
Cancer research 2017 Nov 15;77(22):6144-6156
VEGF-induced intracellular Ca2+ oscillations are down-regulated and do not stimulate angiogenesis in breast cancer-derived endothelial colony forming cells.
Lodola F, Laforenza U, Cattaneo F, Ruffinatti FA, Poletto V, Massa M, Tancredi R, Zuccolo E, Khdar DA, Riccardi A, Biggiogera M, Rosti V, Guerra G, Moccia F
Oncotarget 2017 Nov 10;8(56):95223-95246
Oncotarget 2017 Nov 10;8(56):95223-95246
Increased serum levels of fractalkine and mobilisation of CD34+CD45- endothelial progenitor cells in systemic sclerosis.
Benyamine A, Magalon J, Cointe S, Lacroix R, Arnaud L, Bardin N, Rossi P, Francès Y, Bernard-Guervilly F, Kaplanski G, Harlé JR, Weiller PJ, Berbis P, Braunstein D, Jouve E, Lesavre N, Couranjou F, Dignat-George F, Sabatier F, Paul P, Granel B
Arthritis research & therapy 2017 Mar 20;19(1):60
Arthritis research & therapy 2017 Mar 20;19(1):60
Circulating microparticle subpopulations in systemic lupus erythematosus are affected by disease activity.
López P, Rodríguez-Carrio J, Martínez-Zapico A, Caminal-Montero L, Suárez A
International journal of cardiology 2017 Jun 1;236:138-144
International journal of cardiology 2017 Jun 1;236:138-144
Effects of a New Nutraceutical Formulation (Berberine, Red Yeast Rice and Chitosan) on Non-HDL Cholesterol Levels in Individuals with Dyslipidemia: Results from a Randomized, Double Blind, Placebo-Controlled Study.
Spigoni V, Aldigeri R, Antonini M, Micheli MM, Fantuzzi F, Fratter A, Pellizzato M, Derlindati E, Zavaroni I, Bonadonna RC, Dei Cas A
International journal of molecular sciences 2017 Jul 12;18(7)
International journal of molecular sciences 2017 Jul 12;18(7)
Somatic GNAQ Mutation is Enriched in Brain Endothelial Cells in Sturge-Weber Syndrome.
Huang L, Couto JA, Pinto A, Alexandrescu S, Madsen JR, Greene AK, Sahin M, Bischoff J
Pediatric neurology 2017 Feb;67:59-63
Pediatric neurology 2017 Feb;67:59-63
Cell therapy in critical limb ischemia: A comprehensive analysis of two cell therapy products.
Tournois C, Pignon B, Sevestre MA, Al-Rifai R, Creuza V, Poitevin G, François C, Nguyen P
Cytotherapy 2017 Feb;19(2):299-310
Cytotherapy 2017 Feb;19(2):299-310
Vildagliptin, but not glibenclamide, increases circulating endothelial progenitor cell number: a 12-month randomized controlled trial in patients with type 2 diabetes.
Dei Cas A, Spigoni V, Cito M, Aldigeri R, Ridolfi V, Marchesi E, Marina M, Derlindati E, Aloe R, Bonadonna RC, Zavaroni I
Cardiovascular diabetology 2017 Feb 23;16(1):27
Cardiovascular diabetology 2017 Feb 23;16(1):27
BMP4/Id2 signaling pathway is a novel therapeutic target for late outgrowth endothelial progenitor cell-mediated endothelial injury repair.
Xia WH, Chen L, Liang JW, Zhang XY, Su C, Tong X, He J, Li Y, Cao Z, Lin XF, Tao J
International journal of cardiology 2017 Feb 1;228:796-804
International journal of cardiology 2017 Feb 1;228:796-804
Chromatin and Transcriptional Analysis of Mesoderm Progenitor Cells Identifies HOPX as a Regulator of Primitive Hematopoiesis.
Palpant NJ, Wang Y, Hadland B, Zaunbrecher RJ, Redd M, Jones D, Pabon L, Jain R, Epstein J, Ruzzo WL, Zheng Y, Bernstein I, Margolin A, Murry CE
Cell reports 2017 Aug 15;20(7):1597-1608
Cell reports 2017 Aug 15;20(7):1597-1608
MicroRNA-134 Contributes to Glucose-Induced Endothelial Cell Dysfunction and This Effect Can Be Reversed by Far-Infrared Irradiation.
Wang HW, Su SH, Wang YL, Chang ST, Liao KH, Lo HH, Chiu YL, Hsieh TH, Huang TS, Lin CS, Cheng SM, Cheng CC
PloS one 2016;11(1):e0147067
PloS one 2016;11(1):e0147067
Mycobacterium tuberculosis exploits the formation of new blood vessels for its dissemination.
Polena H, Boudou F, Tilleul S, Dubois-Colas N, Lecointe C, Rakotosamimanana N, Pelizzola M, Andriamandimby SF, Raharimanga V, Charles P, Herrmann JL, Ricciardi-Castagnoli P, Rasolofo V, Gicquel B, Tailleux L
Scientific reports 2016 Sep 12;6:33162
Scientific reports 2016 Sep 12;6:33162
Endothelial cell colony forming units derived from malignant breast diseases are resistant to tumor necrosis factor-α-induced apoptosis.
Chou CP, Jiang SS, Pan HB, Yen YC, Tseng HH, Hung YT, Wang SH, Chen YL, Chen YW
Scientific reports 2016 Nov 24;6:37450
Scientific reports 2016 Nov 24;6:37450
Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification.
Reischauer S, Stone OA, Villasenor A, Chi N, Jin SW, Martin M, Lee MT, Fukuda N, Marass M, Witty A, Fiddes I, Kuo T, Chung WS, Salek S, Lerrigo R, Alsiö J, Luo S, Tworus D, Augustine SM, Mucenieks S, Nystedt B, Giraldez AJ, Schroth GP, Andersson O, Stainier DY
Nature 2016 Jul 14;535(7611):294-8
Nature 2016 Jul 14;535(7611):294-8
Dysregulation of ossification-related miRNAs in circulating osteogenic progenitor cells obtained from patients with aortic stenosis.
Takahashi K, Satoh M, Takahashi Y, Osaki T, Nasu T, Tamada M, Okabayashi H, Nakamura M, Morino Y
Clinical science (London, England : 1979) 2016 Jul 1;130(13):1115-24
Clinical science (London, England : 1979) 2016 Jul 1;130(13):1115-24
Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells.
Gori JL, Butler JM, Chan YY, Chandrasekaran D, Poulos MG, Ginsberg M, Nolan DJ, Elemento O, Wood BL, Adair JE, Rafii S, Kiem HP
The Journal of clinical investigation 2015 Mar 2;125(3):1243-54
The Journal of clinical investigation 2015 Mar 2;125(3):1243-54
Generation of articular chondrocytes from human pluripotent stem cells.
Craft AM, Rockel JS, Nartiss Y, Kandel RA, Alman BA, Keller GM
Nature biotechnology 2015 Jun;33(6):638-45
Nature biotechnology 2015 Jun;33(6):638-45
The inflammation, vascular repair and injury responses to exercise in fit males with and without Type 1 diabetes: an observational study.
West DJ, Campbell MD, Gonzalez JT, Walker M, Stevenson EJ, Ahmed FW, Wijaya S, Shaw JA, Weaver JU
Cardiovascular diabetology 2015 Jun 5;14:71
Cardiovascular diabetology 2015 Jun 5;14:71
BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth.
Wang T, Xiao M, Ge Y, Krepler C, Belser E, Lopez-Coral A, Xu X, Zhang G, Azuma R, Liu Q, Liu R, Li L, Amaravadi RK, Xu W, Karakousis G, Gangadhar TC, Schuchter LM, Lieu M, Khare S, Halloran MB, Herlyn M, Kaufman RE
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Apr 1;21(7):1652-64
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Apr 1;21(7):1652-64
Generation, expansion and functional analysis of endothelial cells and pericytes derived from human pluripotent stem cells.
Orlova VV, van den Hil FE, Petrus-Reurer S, Drabsch Y, Ten Dijke P, Mummery CL
Nature protocols 2014;9(6):1514-31
Nature protocols 2014;9(6):1514-31
The relationship between endothelial progenitor cell populations and epicardial and microvascular coronary disease-a cellular, angiographic and physiologic study.
Chan KH, Simpson PJ, Yong AS, Dunn LL, Chawantanpipat C, Hsu C, Yu Y, Keech AC, Celermajer DS, Ng MK
PloS one 2014;9(4):e93980
PloS one 2014;9(4):e93980
Hypoxia-controlled EphA3 marks a human endometrium-derived multipotent mesenchymal stromal cell that supports vascular growth.
To C, Farnsworth RH, Vail ME, Chheang C, Gargett CE, Murone C, Llerena C, Major AT, Scott AM, Janes PW, Lackmann M
PloS one 2014;9(11):e112106
PloS one 2014;9(11):e112106
IFNα serum levels are associated with endothelial progenitor cells imbalance and disease features in rheumatoid arthritis patients.
Rodríguez-Carrio J, de Paz B, López P, Prado C, Alperi-López M, Ballina-García FJ, Suárez A
PloS one 2014;9(1):e86069
PloS one 2014;9(1):e86069
Phenotyping of human melanoma cells reveals a unique composition of receptor targets and a subpopulation co-expressing ErbB4, EPO-R and NGF-R.
Mirkina I, Hadzijusufovic E, Krepler C, Mikula M, Mechtcheriakova D, Strommer S, Stella A, Jensen-Jarolim E, Höller C, Wacheck V, Pehamberger H, Valent P
PloS one 2014;9(1):e84417
PloS one 2014;9(1):e84417
Bone marrow-derived cells are implicated as a source of lymphatic endothelial progenitors in human breast cancer.
Van't Hull EF, Bron S, Henry L, Ifticene-Treboux A, Turrini R, Coukos G, Delaloye JF, Doucey MA
Oncoimmunology 2014;3:e29080
Oncoimmunology 2014;3:e29080
Efficiency of statin treatment on EPC recruitment depends on baseline EPC titer and does not improve angiographic outcome in coronary artery disease patients treated with the Genous stent.
den Dekker WK, Houtgraaf JH, Rowland SM, Ligtenberg E, de Boer SP, de Jong R, de Winter RJ, den Heijer P, Zijlstra F, Serruys PW, Cheng C, Duckers HJ
Cell transplantation 2014;23(12):1525-35
Cell transplantation 2014;23(12):1525-35
Laminin promotes vascular network formation in 3D in vitro collagen scaffolds by regulating VEGF uptake.
Stamati K, Priestley JV, Mudera V, Cheema U
Experimental cell research 2014 Sep 10;327(1):68-77
Experimental cell research 2014 Sep 10;327(1):68-77
Migratory activity of circulating mononuclear cells is associated with cardiovascular mortality in type 2 diabetic patients with critical limb ischemia.
Spinetti G, Specchia C, Fortunato O, Sangalli E, Clerici G, Caminiti M, Airoldi F, Losa S, Emanueli C, Faglia E, Madeddu P
Diabetes care 2014 May;37(5):1410-7
Diabetes care 2014 May;37(5):1410-7
The dipeptidyl peptidase-4 inhibitor saxagliptin improves function of circulating pro-angiogenic cells from type 2 diabetic patients.
Poncina N, Albiero M, Menegazzo L, Cappellari R, Avogaro A, Fadini GP
Cardiovascular diabetology 2014 May 14;13:92
Cardiovascular diabetology 2014 May 14;13:92
Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells.
Kraan J, van den Broek P, Verhoef C, Grunhagen DJ, Taal W, Gratama JW, Sleijfer S
British journal of cancer 2014 Jul 8;111(1):149-56
British journal of cancer 2014 Jul 8;111(1):149-56
Functionality of endothelial cells and pericytes from human pluripotent stem cells demonstrated in cultured vascular plexus and zebrafish xenografts.
Orlova VV, Drabsch Y, Freund C, Petrus-Reurer S, van den Hil FE, Muenthaisong S, Dijke PT, Mummery CL
Arteriosclerosis, thrombosis, and vascular biology 2014 Jan;34(1):177-86
Arteriosclerosis, thrombosis, and vascular biology 2014 Jan;34(1):177-86
The synergistic effect of everolimus and chloroquine on endothelial cell number reduction is paralleled by increased apoptosis and reduced autophagy occurrence.
Grimaldi A, Balestrieri ML, D'Onofrio N, Di Domenico G, Nocera C, Lamberti M, Tonini G, Zoccoli A, Santini D, Caraglia M, Pantano F
PloS one 2013;8(11):e79658
PloS one 2013;8(11):e79658
Circulating endothelial progenitor cells decrease in infants with bronchopulmonary dysplasia and increase after inhaled nitric oxide.
Qi Y, Jiang Q, Chen C, Cao Y, Qian L
PloS one 2013;8(11):e79060
PloS one 2013;8(11):e79060
Functional and molecular characterization of ex vivo cultured epiretinal membrane cells from human proliferative diabetic retinopathy.
Veréb Z, Lumi X, Andjelic S, Globocnik-Petrovic M, Urbancic M, Hawlina M, Facskó A, Petrovski G
BioMed research international 2013;2013:492376
BioMed research international 2013;2013:492376
CXCR4 positive and angiogenic monocytes in myocardial infarction.
Shantsila E, Tapp LD, Wrigley BJ, Montoro-García S, Lip GY
Thrombosis and haemostasis 2013 Feb;109(2):255-62
Thrombosis and haemostasis 2013 Feb;109(2):255-62
Diabetes impairs stem cell and proangiogenic cell mobilization in humans.
Fadini GP, Albiero M, Vigili de Kreutzenberg S, Boscaro E, Cappellari R, Marescotti M, Poncina N, Agostini C, Avogaro A
Diabetes care 2013 Apr;36(4):943-9
Diabetes care 2013 Apr;36(4):943-9
GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC.
Fekete N, Rojewski MT, Fürst D, Kreja L, Ignatius A, Dausend J, Schrezenmeier H
PloS one 2012;7(8):e43255
PloS one 2012;7(8):e43255
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
Pelosi E, Castelli G, Martin-Padura I, Bordoni V, Santoro S, Conigliaro A, Cerio AM, De Santis Puzzonia M, Marighetti P, Biffoni M, Alonzi T, Amicone L, Alcalay M, Bertolini F, Testa U, Tripodi M
PloS one 2012;7(12):e51109
PloS one 2012;7(12):e51109
Cultivation and characterization of cornea limbal epithelial stem cells on lens capsule in animal material-free medium.
Albert R, Veréb Z, Csomós K, Moe MC, Johnsen EO, Olstad OK, Nicolaissen B, Rajnavölgyi E, Fésüs L, Berta A, Petrovski G
PloS one 2012;7(10):e47187
PloS one 2012;7(10):e47187
Successful in vitro expansion and differentiation of cord blood derived CD34+ cells into early endothelial progenitor cells reveals highly differential gene expression.
Ahrens I, Domeij H, Topcic D, Haviv I, Merivirta RM, Agrotis A, Leitner E, Jowett JB, Bode C, Lappas M, Peter K
PloS one 2011;6(8):e23210
PloS one 2011;6(8):e23210
Oligo-guanosine nucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis.
Narazaki M, Segarra M, Hou X, Tanaka T, Li X, Tosato G
Blood 2010 Oct 21;116(16):3099-107
Blood 2010 Oct 21;116(16):3099-107
Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors.
Nilsson MB, Zage PE, Zeng L, Xu L, Cascone T, Wu HK, Saigal B, Zweidler-McKay PA, Heymach JV
Oncogene 2010 May 20;29(20):2938-49
Oncogene 2010 May 20;29(20):2938-49
Distraction osteogenesis induces endothelial progenitor cell mobilization without inflammatory response in man.
Lee DY, Cho TJ, Lee HR, Park MS, Yoo WJ, Chung CY, Choi IH
Bone 2010 Mar;46(3):673-9
Bone 2010 Mar;46(3):673-9
Neuropilin-1 regulates platelet-derived growth factor receptor signalling in mesenchymal stem cells.
Ball SG, Bayley C, Shuttleworth CA, Kielty CM
The Biochemical journal 2010 Mar 15;427(1):29-40
The Biochemical journal 2010 Mar 15;427(1):29-40
VEGFR2 is selectively expressed by FOXP3high CD4+ Treg.
Suzuki H, Onishi H, Wada J, Yamasaki A, Tanaka H, Nakano K, Morisaki T, Katano M
European journal of immunology 2010 Jan;40(1):197-203
European journal of immunology 2010 Jan;40(1):197-203
Comparison of endothelial progenitor cell function in type 2 diabetes with good and poor glycemic control.
Churdchomjan W, Kheolamai P, Manochantr S, Tapanadechopone P, Tantrawatpan C, U-Pratya Y, Issaragrisil S
BMC endocrine disorders 2010 Apr 7;10:5
BMC endocrine disorders 2010 Apr 7;10:5
Colocalization of the VEGF-R2 and the common IL-3/GM-CSF receptor beta chain to lipid rafts leads to enhanced p38 activation.
Saulle E, Riccioni R, Coppola S, Parolini I, Diverio D, Riti V, Mariani G, Laufer S, Sargiacomo M, Testa U
British journal of haematology 2009 May;145(3):399-411
British journal of haematology 2009 May;145(3):399-411
Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells.
Saeki K, Yogiashi Y, Nakahara M, Nakamura N, Matsuyama S, Koyanagi A, Yagita H, Koyanagi M, Kondo Y, Yuo A
Journal of cellular physiology 2008 Oct;217(1):261-80
Journal of cellular physiology 2008 Oct;217(1):261-80
Endothelial progenitor cell levels in obese men with the metabolic syndrome and the effect of simvastatin monotherapy vs. simvastatin/ezetimibe combination therapy.
Westerweel PE, Visseren FL, Hajer GR, Olijhoek JK, Hoefer IE, de Bree P, Rafii S, Doevendans PA, Verhaar MC
European heart journal 2008 Nov;29(22):2808-17
European heart journal 2008 Nov;29(22):2808-17
Tumor necrosis factor-alpha and endothelial cells modulate Notch signaling in the bone marrow microenvironment during inflammation.
Fernandez L, Rodriguez S, Huang H, Chora A, Fernandes J, Mumaw C, Cruz E, Pollok K, Cristina F, Price JE, Ferkowicz MJ, Scadden DT, Clauss M, Cardoso AA, Carlesso N
Experimental hematology 2008 May;36(5):545-558
Experimental hematology 2008 May;36(5):545-558
Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population.
Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, Henckaerts E, Bonham K, Abbott GW, Linden RM, Field LJ, Keller GM
Nature 2008 May 22;453(7194):524-8
Nature 2008 May 22;453(7194):524-8
Alternative splicing of vasohibin-1 generates an inhibitor of endothelial cell proliferation, migration, and capillary tube formation.
Kern J, Bauer M, Rychli K, Wojta J, Ritsch A, Gastl G, Gunsilius E, Untergasser G
Arteriosclerosis, thrombosis, and vascular biology 2008 Mar;28(3):478-84
Arteriosclerosis, thrombosis, and vascular biology 2008 Mar;28(3):478-84
Late outgrowth endothelial progenitor cells in patients with age-related macular degeneration.
Thill M, Strunnikova NV, Berna MJ, Gordiyenko N, Schmid K, Cousins SW, Thompson DJ, Csaky KG
Investigative ophthalmology & visual science 2008 Jun;49(6):2696-708
Investigative ophthalmology & visual science 2008 Jun;49(6):2696-708
Microtubule-targeted drugs inhibit VEGF receptor-2 expression by both transcriptional and post-transcriptional mechanisms.
Meissner M, Pinter A, Michailidou D, Hrgovic I, Kaprolat N, Stein M, Holtmeier W, Kaufmann R, Gille J
The Journal of investigative dermatology 2008 Aug;128(8):2084-91
The Journal of investigative dermatology 2008 Aug;128(8):2084-91
Sulfated polysaccharides identified as inducers of neuropilin-1 internalization and functional inhibition of VEGF165 and semaphorin3A.
Narazaki M, Segarra M, Tosato G
Blood 2008 Apr 15;111(8):4126-36
Blood 2008 Apr 15;111(8):4126-36
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Lee PY, Li Y, Richards HB, Chan FS, Zhuang H, Narain S, Butfiloski EJ, Sobel ES, Reeves WH, Segal MS
Arthritis and rheumatism 2007 Nov;56(11):3759-69
Arthritis and rheumatism 2007 Nov;56(11):3759-69
Notch alters VEGF responsiveness in human and murine endothelial cells by direct regulation of VEGFR-3 expression.
Shawber CJ, Funahashi Y, Francisco E, Vorontchikhina M, Kitamura Y, Stowell SA, Borisenko V, Feirt N, Podgrabinska S, Shiraishi K, Chawengsaksophak K, Rossant J, Accili D, Skobe M, Kitajewski J
The Journal of clinical investigation 2007 Nov;117(11):3369-82
The Journal of clinical investigation 2007 Nov;117(11):3369-82
Vascular endothelial growth factor can signal through platelet-derived growth factor receptors.
Ball SG, Shuttleworth CA, Kielty CM
The Journal of cell biology 2007 May 7;177(3):489-500
The Journal of cell biology 2007 May 7;177(3):489-500
Blood-based biomarkers of SU11248 activity and clinical outcome in patients with metastatic imatinib-resistant gastrointestinal stromal tumor.
Norden-Zfoni A, Desai J, Manola J, Beaudry P, Force J, Maki R, Folkman J, Bello C, Baum C, DePrimo SE, Shalinsky DR, Demetri GD, Heymach JV
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 May 1;13(9):2643-50
Clinical cancer research : an official journal of the American Association for Cancer Research 2007 May 1;13(9):2643-50
Increased circulating endothelial progenitor cells in septic patients: correlation with survival.
Rafat N, Hanusch C, Brinkkoetter PT, Schulte J, Brade J, Zijlstra JG, van der Woude FJ, van Ackern K, Yard BA, Beck GCh
Critical care medicine 2007 Jul;35(7):1677-84
Critical care medicine 2007 Jul;35(7):1677-84
VEGFR2 expressing circulating (progenitor) cell populations in volunteers and cancer patients.
Vroling L, Yuana Y, Schuurhuis GJ, van Hinsbergh VW, Gundy C, de Haas R, van Cruijsen H, Boven E, Hoekman K, Broxterman HJ
Thrombosis and haemostasis 2007 Aug;98(2):440-50
Thrombosis and haemostasis 2007 Aug;98(2):440-50
Ligand-induced internalization selects use of common receptor neuropilin-1 by VEGF165 and semaphorin3A.
Narazaki M, Tosato G
Blood 2006 May 15;107(10):3892-901
Blood 2006 May 15;107(10):3892-901
Enalapril increases ischemia-induced endothelial progenitor cell mobilization through manipulation of the CD26 system.
Wang CH, Verma S, Hsieh IC, Chen YJ, Kuo LT, Yang NI, Wang SY, Wu MY, Hsu CM, Cheng CW, Cherng WJ
Journal of molecular and cellular cardiology 2006 Jul;41(1):34-43
Journal of molecular and cellular cardiology 2006 Jul;41(1):34-43
Isolation of an adult blood-derived progenitor cell population capable of differentiation into angiogenic, myocardial and neural lineages.
Porat Y, Porozov S, Belkin D, Shimoni D, Fisher Y, Belleli A, Czeiger D, Silverman WF, Belkin M, Battler A, Fulga V, Savion N
British journal of haematology 2006 Dec;135(5):703-14
British journal of haematology 2006 Dec;135(5):703-14
Expansion of human SCID-repopulating cells under hypoxic conditions.
Danet GH, Pan Y, Luongo JL, Bonnet DA, Simon MC
The Journal of clinical investigation 2003 Jul;112(1):126-35
The Journal of clinical investigation 2003 Jul;112(1):126-35
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- Experimental details
- Detection of VEGF R2/KDR/Flk-1 in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Mouse Anti-Human VEGF R2/KDR/Flk-1 PE-conjugated Mono-clonal Antibody (Catalog # FAB357P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.