ABIN967246

antibody from antibodies-online

Targeting: KDR CD309, FLK1, VEGFR, VEGFR2

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN967246

Provider

antibodies-online

Product name

anti-Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase) (KDR) (pTyr951) antibody

Antibody type

Polyclonal

Antigen

The antiserum was produced against synthesized phosphopeptide derived from human VEGFR2 around the phosphorylation site of tyrosine 951 (K-D-YP-V-G).

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human, Mouse, Rat

Host

Rabbit

Epitope

pTyr951

Vial size

100 μg

Concentration

100ug/100ul.

Storage

-20°C

References

Submitted references

Tyrosine residues 951 and 1059 of vascular endothelial growth factor receptor-2 (KDR) are essential for vascular permeability factor/vascular endothelial growth factor-induced endothelium migration and proliferation, respectively.

Zeng H, Sanyal S, Mukhopadhyay D
The Journal of biological chemistry 2001 Aug 31;276(35):32714-9

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Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization.

Dougher M, Terman BI
Oncogene 1999 Feb 25;18(8):1619-27