Antibody data
- Antibody Data
- Antigen structure
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- Product number
- CABT-B1602 - Provider product page
- Provider
- Creative Diagnostics
- Product name
- Anti-IDH1 polyclonal antibody
- Antibody type
- Polyclonal
- Description
- Isocitrate dehydrogenase 1 (IDH1) is a 46 kDa NADP-dependent enzyme, which catalyzes the decarboxylation of isocitrate into Ï«-ketoglutarate. IDH1 may also play a role in the prevention of oxidative damage, and the shuttling of proteins to peroxisomes. It is widely reported that mutations in IDH1 result in multiple forms of gliomas. The Arginine to Serine substitution at amino acid 132 is seen in gliomas, abolishes magnesium binding and alters enzyme activity so that isocitrate is no longer converted to alpha-ketoglutarate but instead alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 100 _g
- Concentration
- Please refer to lot specific datasheet.
- Storage
- Stable for 1 year at 2-8°C from date of receipt.
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