IDH1

gene product
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
More gene data

Featured antibodies

Antibodies

 

Filters

Antibodypedia Validation Initiative

Validation method

Application

Reference

Provider

Host

Reactivity

Antibody type

Conjugate

  or   Clear
Validated by best practice
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Validated within AVI
Eligible for validation within AVI
382 antibodies from 36 providers.

Antibody properties

Applications

or Cancel
AntibodyRefsTypeAVIWBELICCIPIHCFC
NovoPro Bioscience Inc.
9 antibodies
Proteintech Group
3 antibodies
antibodies-online
74 antibodies
Invitrogen Antibodies
6 antibodies
NSJ Bioreagents
8 antibodies
Abgent
7 antibodies
OriGene
12 antibodies
Arigo
3 antibodies
Biorbyt
22 antibodies
Bioworld Technology, Inc
1 antibody
Novus Biologicals
16 antibodies
Aviva Systems Biology
6 antibodies
GeneTex
6 antibodies
Atlas Antibodies
3 antibodies
Cell Signaling Technology, Inc
2 antibodies
R&D Systems
1 antibody
LifeSpan BioSciences, Inc.
52 antibodies
Acris Antibodies GmbH
11 antibodies
Bethyl Laboratories, Inc.
4 antibodies
FabGennix
3 antibodies
BioLegend
1 antibody
Abnova Corporation
6 antibodies
RabMAbs
5 antibodies
United States Biological
52 antibodies
MyBioSource
13 antibodies
Everest Biotech
2 antibodies
St John's Laboratory
2 antibodies
Creative Diagnostics
17 antibodies
Creative Biolabs
3 antibodies
RayBiotech, Inc.
6 antibodies
EMD Millipore
6 antibodies
Sigma-Aldrich
5 antibodies
Abbiotec
1 antibody
BosterBio
1 antibody
Rockland Immunochemicals, Inc.
1 antibody