Tissue expression
Cell line expression
Protein structure
IDH1
Isocitrate dehydrogenase (NADP(+)) 1Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]
Top validated antibodies |
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Proteintech Group | 12332-1-AP | 51 references | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
|
Invitrogen Antibodies | 12332-1-AP | Polyclonal |
WB
ICC
IP
IHC
FC
OA |
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GeneTex | GTX105179 | 2 references | Polyclonal |
WB
IP
IHC
|
|
Atlas Antibodies | HPA035248 | 1 references | Polyclonal |
WB
IHC |
|
NovoPro Bioscience Inc. | 111601 | Polyclonal |
WB
EL
ICC
IP
IHC
FC |
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