11149-1-AP

antibody from Proteintech Group

Targeting: EIF4E EIF4E1, EIF4EL1, EIF4F

Provider product page for 11149-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [30]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 11149-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#11149-1-AP, RRID:AB_2097686
Product name: CBP,EIF4E antibody
Antibody type: Polyclonal
Description: KD/KO validated CBP,EIF4E antibody (Cat. #11149-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: FC, IF, IHC, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

EIF4E protein structure - 11149-1-AP shown in red.

Submitted references Identification of m1A/m6A/m5C/m7G-related genes and clusters associated with neuropathic pain.

Tan L, Gan X, Lu D, Liang Y, Fu W, Gan Z, Wang K, Tang H, Yang P
Frontiers in neurology 2026;17:1592545

mRNA caps accumulate in stress granules and are essential for their formation.

Guo M, Feng Y, Qi G, Ma W, He X, Li R, Liu Y, Wang J
Cellular and molecular life sciences : CMLS 2025 Nov 25;82(1):420

YTHDF1 differentiates the contributing roles of mTORC1 in aging.

Xu C, Yu C, Zhang J, Zhang Z, Zhang J, Meng Y, Wang M, Wen M, Chen J, Ning Y, Chen X, Gu J, Su W, Liu B
Molecular cell 2025 Jun 5;85(11):2194-2210.e8

N(6)-methyladenosine in 28S rRNA promotes oncogenic mRNA translation and tyrosine catabolism.

Chen B, Li L, Huang Y, Ma J, Ji F, Chen Y, Wu L, Peng H
Cell reports 2025 Jan 28;44(1):115139

EV-D68 cleaves LARP1 and PABPC1 by 3Cpro to redirect host mRNA translation machinery toward its genomic RNA.

Tan R, Zhang Y, Huang M, Chen H, Liu Z, Wang Z, Li X, Wang T, Wang Z
PLoS pathogens 2025 Apr;21(4):e1013098

Integrated network pharmacology, proteomics, molecular docking, and experiments in vivo and in vitro to explore the efficacy and potential mechanism of bufalin against hepatocellular carcinoma angiogenesis.

Li Y, Zhou L, Sun K, Guo R, Li Z, Wen Q, Fu G, Yang S
Journal of ethnopharmacology 2025 Apr 9;345:119589

RNA-binding motif protein 28 enhances angiogenesis by improving STAT3 translation in hepatocellular carcinoma.

Han H, Yuan Y, Li C, Liu L, Yu H, Han G, Wang Q, Lin M, Huang J
Cancer letters 2024 Nov 1;604:217191

The RNA m(6)A reader IGF2BP3 regulates NFAT1/IRF1 axis-mediated anti-tumor activity in gastric cancer.

Ge L, Rui Y, Wang C, Wu Y, Wang H, Wang J
Cell death & disease 2024 Mar 6;15(3):192

Unraveling the role of PBK in glioblastoma: from molecular mechanisms to therapeutic targets.

Zhang Y, Luan M
Annals of medicine and surgery (2012) 2024 Dec;86(12):7147-7154

Decreased RNA-binding protein heterogeneous nuclear ribonucleoprotein U improves multiple myeloma sensitivity to lenalidomide.

Lin Z, Zhang Y, Liu X, Luo H, Li Q, Gao Q, Wang X, Wen J, Li L, Feng Y, Wang F, Huang J, Zhai X, Zhang L, Niu T, Zheng Y
British journal of haematology 2024 Aug;205(2):594-606

Yin Yang 1 suppresses tumor invasion and metastasis in nasopharyngeal carcinoma by negatively regulating eIF4E transcriptional activity and expression.

Li M, Duan Y, Wei J, Chen S, Xue C, Zheng L, Deng H, Fan S, Xiong W, Li G, Tan M, Tang F, She K, Zhou M
American journal of cancer research 2023;13(8):3763-3780

TREM-1 triggers necroptosis of macrophages through mTOR-dependent mitochondrial fission during acute lung injury.

Zhong WJ, Zhang J, Duan JX, Zhang CY, Ma SC, Li YS, Yang NS, Yang HH, Xiong JB, Guan CX, Jiang ZX, You ZJ, Zhou Y
Journal of translational medicine 2023 Mar 6;21(1):179

N7-methylguanosin regulators-mediated methylation modification patterns and characterization of the immune microenvironment in lower-grade glioma.

Maimaiti A, Feng Z, Liu Y, Turhon M, Xie Z, Baihetiyaer Y, Wang X, Kasimu M, Jiang L, Wang Y, Wang Z, Pei Y
European journal of medical research 2023 Mar 30;28(1):144

Non-canonical function of histone methyltransferase G9a in the translational regulation of chronic inflammation.

Muneer A, Wang L, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Jain K, Strahl BD, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
Cell chemical biology 2023 Dec 21;30(12):1525-1541.e7

Selinexor inhibits growth of patient derived chordomas in vivo as a single agent and in combination with abemaciclib through diverse mechanisms.

Walker CJ, Chang H, Henegar L, Kashyap T, Shacham S, Sommer J, Wick MJ, Levy J, Landesman Y
Frontiers in oncology 2022;12:808021

Elaiophylin triggers paraptosis and preferentially kills ovarian cancer drug-resistant cells by inducing MAPK hyperactivation.

Li GN, Zhao XJ, Wang Z, Luo MS, Shi SN, Yan DM, Li HY, Liu JH, Yang Y, Tan JH, Zhang ZY, Chen RQ, Lai HL, Huang XY, Zhou JF, Ma D, Fang Y, Gao QL
Signal transduction and targeted therapy 2022 Sep 12;7(1):317

Small-Molecule RAF265 as an Antiviral Therapy Acts against PEDV Infection.

Wang J, Tian WJ, Li CC, Zhang XZ, Fan K, Li SL, Wang XJ
Viruses 2022 Oct 15;14(10)

mTORC1 Mediates the Processes of Lysine Regulating Satellite Cells Proliferation, Apoptosis, and Autophagy.

Liu M, Yue Z, Zhang B, Li F, Liu L, Li F
Metabolites 2022 Aug 25;12(9)

RNA m(6)A methylation regulates dissemination of cancer cells by modulating expression and membrane localization of β-catenin.

Li J, Xie G, Tian Y, Li W, Wu Y, Chen F, Lin Y, Lin X, Wing-Ngor Au S, Cao J, He W, Wang H
Molecular therapy : the journal of the American Society of Gene Therapy 2022 Apr 6;30(4):1578-1596

KDM6A promotes imatinib resistance through YY1-mediated transcriptional upregulation of TRKA independently of its demethylase activity in chronic myelogenous leukemia.

Zhang C, Shen L, Zhu Y, Xu R, Deng Z, Liu X, Ding Y, Wang C, Shi Y, Bei L, Wei D, Thorne RF, Zhang XD, Yu L, Chen S
Theranostics 2021;11(6):2691-2705

Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.

Sun Y, Zhang H, Wu Z, Yu X, Yin Y, Qian S, Wang Z, Huang J, Wang W, Liu T, Xue W, Chen G
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396

Novel gene-specific translation mechanism of dysregulated, chronic inflammation reveals promising, multifaceted COVID-19 therapeutics.

Wang L, Muneer A, Xie L, Zhang F, Wu B, Mei L, Lenarcic EM, Feng EH, Song J, Xiong Y, Yu X, Wang C, Gheorghe C, Torralba K, Cook JG, Wan YY, Moorman NJ, Song H, Jin J, Chen X
bioRxiv : the preprint server for biology 2020 Nov 16;

Proteomic analysis of Trypanosoma cruzi spliceosome complex.

Barbosa RL, da Cunha JPC, Menezes AT, Melo RFP, Elias MC, Silber AM, Coltri PP
Journal of proteomics 2020 Jul 15;223:103822

The Natural Compound Homoharringtonine Presents Broad Antiviral Activity In Vitro and In Vivo.

Dong HJ, Wang ZH, Meng W, Li CC, Hu YX, Zhou L, Wang XJ
Viruses 2018 Nov 1;10(11)

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function.

Du Y, Hou G, Zhang H, Dou J, He J, Guo Y, Li L, Chen R, Wang Y, Deng R, Huang J, Jiang B, Xu M, Cheng J, Chen GQ, Zhao X, Yu J
Nucleic acids research 2018 Jun 1;46(10):5195-5208

Multifunctional viral protein γ34.5 manipulates nucleolar protein NOP53 for optimal viral replication of HSV-1.

Meng W, Han SC, Li CC, Dong HJ, Wang XJ
Cell death & disease 2018 Jan 24;9(2):103

HBXIP and LSD1 Scaffolded by lncRNA Hotair Mediate Transcriptional Activation by c-Myc.

Li Y, Wang Z, Shi H, Li H, Li L, Fang R, Cai X, Liu B, Zhang X, Ye L
Cancer research 2016 Jan 15;76(2):293-304

Pemetrexed induces G1 phase arrest and apoptosis through inhibiting Akt activation in human non small lung cancer cell line A549.

Wu DM, Zhang P, Xu GC, Tong AP, Zhou C, Lang JY, Wang CT
Asian Pacific journal of cancer prevention : APJCP 2015;16(4):1507-13

Identification of the receptor tyrosine kinases (RTKs)-oriented functional targets of miR-206 by an antibody-based protein array.

Cui Y, Xie S, Luan J, Zhou X, Han J
FEBS letters 2015 Jul 22;589(16):2131-5

mTOR inhibitor AZD8055 inhibits proliferation and induces apoptosis in laryngeal carcinoma.

Zhao L, Teng B, Wen L, Feng Q, Wang H, Li N, Wang Y, Liang Z
International journal of clinical and experimental medicine 2014;7(2):337-47

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HEK-293 cells were subjected to SDS PAGE followed by western blot with 11149-1-AP(EIF4E antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunofluorescent analysis of HepG2 cells, using EIF4E antibody 11149-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 11149-1-AP(EIF4E antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 11149-1-AP(EIF4E antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue